ENSMUSG00000020719


Mus musculus

Features
Gene ID: ENSMUSG00000020719
  
Biological name :Ddx5
  
Synonyms : Ddx5 / Mus musculus DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 (Ddx5), transcript variant 3, mRNA.
  
Possible biological names infered from orthology : DEAD-box helicase 5 / P17844
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 106780355
Gene end: 106789185
  
Corresponding Affymetrix probe sets: 10385484 (MoGene1.0st)   10392251 (MoGene1.0st)   1419653_a_at (Mouse Genome 430 2.0 Array)   1423645_a_at (Mouse Genome 430 2.0 Array)   1433809_at (Mouse Genome 430 2.0 Array)   1433810_x_at (Mouse Genome 430 2.0 Array)   1438371_x_at (Mouse Genome 430 2.0 Array)   1454793_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021062
Ensembl peptide - ENSMUSP00000121733
Ensembl peptide - ENSMUSP00000138184
Ensembl peptide - ENSMUSP00000138237
Ensembl peptide - ENSMUSP00000116859
NCBI entrez gene - 13207     See in Manteia.
MGI - MGI:105037
RefSeq - XM_006532137
RefSeq - NM_001355676
RefSeq - NM_001355677
RefSeq - NM_007840
RefSeq - XM_006532135
RefSeq - XM_006532136
RefSeq Peptide - NP_001342606
RefSeq Peptide - NP_031866
RefSeq Peptide - NP_001342605
swissprot - B1ARC0
swissprot - S4R1E3
swissprot - S4R1I6
swissprot - B1ARB9
swissprot - Q8BTS0
Ensembl - ENSMUSG00000020719
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx5ENSDARG00000038068Danio rerio
 DDX5ENSGALG00000003532Gallus gallus
 DDX5ENSG00000108654Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ddx17 / Q501J6 / Probable ATP-dependent RNA helicase DDX17 / Q92841* / DEAD-box helicase 17*ENSMUSG0000005506569
Ddx42 / Q810A7 / ATP-dependent RNA helicase DDX42 / Q86XP3* / DEAD-box helicase 42*ENSMUSG0000002070536
Ddx43 / DEAD-box helicase 43 / Q9NXZ2*ENSMUSG0000007029133


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR012587  RNA helicase p68 repeat
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR033488  RNA helicase p68 (DDX5)


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000380 alternative mRNA splicing, via spliceosome IEA
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IEA
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0009299 mRNA transcription IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0030521 androgen receptor signaling pathway IEA
 biological_processGO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0045069 regulation of viral genome replication IEA
 biological_processGO:0060765 regulation of androgen receptor signaling pathway IEA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IEA
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IEA
 cellular_componentGO:0071141 SMAD protein complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003724 RNA helicase activity IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0035500 MH2 domain binding IEA
 molecular_functionGO:0036002 pre-mRNA binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA
 molecular_functionGO:0050681 androgen receptor binding IEA
 molecular_functionGO:0070412 R-SMAD binding IEA
 molecular_functionGO:0070878 primary miRNA binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
mRNA Splicing - Major Pathway
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Vps52tm1.1Kab/Vps52tm1.2Kab,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL * C57BL/6 * CBA * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr