ENSMUSG00000042557


Mus musculus

Features
Gene ID: ENSMUSG00000042557
  
Biological name :Sin3a
  
Synonyms : Mus musculus transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 4, mRNA. / Q60520 / Sin3a
  
Possible biological names infered from orthology : Q96ST3 / SIN3 transcription regulator family member A
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 57072040
Gene end: 57128366
  
Corresponding Affymetrix probe sets: 10585625 (MoGene1.0st)   1419101_at (Mouse Genome 430 2.0 Array)   1419102_at (Mouse Genome 430 2.0 Array)   1449343_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130221
Ensembl peptide - ENSMUSP00000129062
Ensembl peptide - ENSMUSP00000130641
Ensembl peptide - ENSMUSP00000045044
Ensembl peptide - ENSMUSP00000126601
Ensembl peptide - ENSMUSP00000126718
Ensembl peptide - ENSMUSP00000128956
NCBI entrez gene - 20466     See in Manteia.
MGI - MGI:107157
RefSeq - XM_017313231
RefSeq - XM_006510891
RefSeq - XM_006510892
RefSeq - XM_006510893
RefSeq - XM_011242683
RefSeq - XM_011242684
RefSeq - XM_011242685
RefSeq - XM_011242686
RefSeq - NM_001110350
RefSeq - NM_001110351
RefSeq - NM_001357754
RefSeq - NM_011378
RefSeq - XM_006510890
RefSeq Peptide - NP_035508
RefSeq Peptide - NP_001103820
RefSeq Peptide - NP_001103821
RefSeq Peptide - NP_001344683
swissprot - Q60520
swissprot - E9Q2L1
swissprot - E9PXF9
Ensembl - ENSMUSG00000042557
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sin3aaENSDARG00000079716Danio rerio
 sin3abENSDARG00000059812Danio rerio
 SIN3AENSGALG00000001644Gallus gallus
 SIN3AENSG00000169375Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sin3b / Q62141 / transcriptional regulator, SIN3B (yeast) / O75182* / SIN3 transcription regulator family member B*ENSMUSG0000003162247


Protein motifs (from Interpro)
Interpro ID Name
 IPR003822  Paired amphipathic helix
 IPR013194  Histone deacetylase interacting domain
 IPR031693  Sin3, C-terminal
 IPR036600  Paired amphipathic helix superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0002218 activation of innate immune response ISO
 biological_processGO:0002230 positive regulation of defense response to virus by host ISO
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006260 DNA replication IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006476 protein deacetylation ISO
 biological_processGO:0007568 aging IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010817 regulation of hormone levels IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0016575 histone deacetylation IBA
 biological_processGO:0031937 positive regulation of chromatin silencing ISO
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0042754 negative regulation of circadian rhythm IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051595 response to methylglyoxal IDA
 biological_processGO:0071333 cellular response to glucose stimulus IDA
 biological_processGO:1900181 negative regulation of protein localization to nucleus ISO
 biological_processGO:1901675 negative regulation of histone H3-K27 acetylation ISO
 biological_processGO:1903351 cellular response to dopamine IEA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding ISO
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IPI
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0016580 Sin3 complex IBA
 cellular_componentGO:0017053 transcriptional repressor complex IPI
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding ISO
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004407 histone deacetylase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0033558 protein deacetylase activity ISO


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd4tm2Litt/Cd4tm2Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Pkd2tm1Som/Pkd2tm2Som
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex
 ENSMUSG00000049300 Prmt6 / Q6NZB1 / protein arginine N-methyltransferase 6 / Q96LA8* / protein arginine methyltransferase 6*  / complex / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / complex / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / reaction / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / reaction / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex






 

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