ENSMUSG00000031622


Mus musculus

Features
Gene ID: ENSMUSG00000031622
  
Biological name :Sin3b
  
Synonyms : Q62141 / Sin3b / transcriptional regulator, SIN3B (yeast)
  
Possible biological names infered from orthology : O75182 / SIN3 transcription regulator family member B
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 72723285
Gene end: 72758201
  
Corresponding Affymetrix probe sets: 10572838 (MoGene1.0st)   1424355_a_at (Mouse Genome 430 2.0 Array)   1425630_at (Mouse Genome 430 2.0 Array)   1434637_x_at (Mouse Genome 430 2.0 Array)   1452849_at (Mouse Genome 430 2.0 Array)   1455039_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004494
Ensembl peptide - ENSMUSP00000105576
Ensembl peptide - ENSMUSP00000148407
Ensembl peptide - ENSMUSP00000148599
NCBI entrez gene - 20467     See in Manteia.
MGI - MGI:107158
RefSeq - XM_006530789
RefSeq - NM_001113248
RefSeq - NM_009188
RefSeq Peptide - NP_001106719
RefSeq Peptide - NP_033214
swissprot - Q3TN09
swissprot - Q62141
swissprot - A0A1D5RM25
Ensembl - ENSMUSG00000031622
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sin3bENSDARG00000062472Danio rerio
 SIN3BENSGALG00000003771Gallus gallus
 SIN3BENSG00000127511Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sin3a / Q60520 / Mus musculus transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 4, mRNA. / Q96ST3* / SIN3 transcription regulator family member A*ENSMUSG0000004255755


Protein motifs (from Interpro)
Interpro ID Name
 IPR003822  Paired amphipathic helix
 IPR013194  Histone deacetylase interacting domain
 IPR031693  Sin3, C-terminal
 IPR036600  Paired amphipathic helix superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016575 histone deacetylation IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 cellular_componentGO:0000805 X chromosome IDA
 cellular_componentGO:0000806 Y chromosome IDA
 cellular_componentGO:0001741 XY body IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016580 Sin3 complex IBA
 cellular_componentGO:0030849 autosome IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0004407 histone deacetylase activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0010178 increased number of Howell-Jolly bodies "abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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