ENSGALG00000001644


Gallus gallus

Features
Gene ID: ENSGALG00000001644
  
Biological name :SIN3A
  
Synonyms : SIN3A / SIN3 transcription regulator family member A
  
Possible biological names infered from orthology : Mus musculus transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 4, mRNA. / Q60520 / Q96ST3
  
Species: Gallus gallus
  
Chr. number: 10
Strand: -1
Band:
Gene start: 2590070
Gene end: 2610361
  
Corresponding Affymetrix probe sets: Gga.9532.1.S1_at (Chicken Array)   GgaAffx.1073.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002508
NCBI entrez gene - 415307     See in Manteia.
RefSeq - XM_015278821
RefSeq - NM_001293184
RefSeq - XM_015278819
RefSeq - XM_015278820
RefSeq Peptide - NP_001280113
swissprot - E1BX21
Ensembl - ENSGALG00000001644
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sin3aaENSDARG00000079716Danio rerio
 sin3abENSDARG00000059812Danio rerio
 SIN3AENSG00000169375Homo sapiens
 Sin3aENSMUSG00000042557Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIN3B / SIN3 transcription regulator family member B / O75182* / Q62141* / transcriptional regulator, SIN3B (yeast)*ENSGALG0000000377149


Protein motifs (from Interpro)
Interpro ID Name
 IPR003822  Paired amphipathic helix
 IPR013194  Histone deacetylase interacting domain
 IPR031693  Sin3, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006476 protein deacetylation IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0016575 histone deacetylation IBA
 biological_processGO:0031937 positive regulation of chromatin silencing IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0042754 negative regulation of circadian rhythm IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051595 response to methylglyoxal IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:1900181 negative regulation of protein localization to nucleus IEA
 biological_processGO:1901675 negative regulation of histone H3-K27 acetylation IEA
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0016580 Sin3 complex IBA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0004407 histone deacetylase activity IBA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0033558 protein deacetylase activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003297 HDAC1 / P56517 / Histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / complex
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000020078 H3F3C / histone H3.2 / H3.Y* / H3F3B* / H3F3A* / Q6NXT2* / P84243* / P84244* / Histone H3.3 * / H3 histone family member 3B* / H3 histone family member 3A* / H3 histone family member 3C* /...  / complex
 ENSGALG00000016022 RUNX1 / runt related transcription factor 1 / Q01196*  / complex
 ENSGALG00000043062 P84229 / HIST2H3D / Histone H3.2 / Q71DI3* / histone cluster 2 H3 family member d*  / complex
 ENSGALG00000042491 P62801 / Histone H4   / complex






 

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