ENSMUSG00000020962


Mus musculus

Features
Gene ID: ENSMUSG00000020962
  
Biological name :Gtf2a1
  
Synonyms : Gtf2a1 / Q99PM3 / Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA alpha chain Transcription initiation factor IIA beta chain
  
Possible biological names infered from orthology : general transcription factor IIA subunit 1 / P52655
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: D3
Gene start: 91555262
Gene end: 91590487
  
Corresponding Affymetrix probe sets: 10401882 (MoGene1.0st)   1421357_at (Mouse Genome 430 2.0 Array)   1433511_at (Mouse Genome 430 2.0 Array)   1454631_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021345
Ensembl peptide - ENSMUSP00000068562
NCBI entrez gene - 83602     See in Manteia.
MGI - MGI:1933277
RefSeq - XM_017315260
RefSeq - NM_031391
RefSeq - NM_175335
RefSeq Peptide - NP_780544
RefSeq Peptide - NP_113568
swissprot - Q149E9
swissprot - Q99PM3
Ensembl - ENSMUSG00000020962
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gtf2a1ENSDARG00000011000Danio rerio
 GTF2A1ENSGALG00000010576Gallus gallus
 GTF2A1ENSG00000165417Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R4I4 / Gtf2a1l / TFIIA-alpha and beta-like factor ENSMUSG0000002415435


Protein motifs (from Interpro)
Interpro ID Name
 IPR004855  Transcription factor IIA, alpha/beta subunit
 IPR009083  Transcription factor IIA, helical
 IPR009088  Transcription factor IIA, beta-barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005669 transcription factor TFIID complex IEA
 cellular_componentGO:0005672 transcription factor TFIIA complex IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0017025 TBP-class protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
RNA Polymerase II Pre-transcription Events
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0008279 arrest of spermiogenesis "block in the process by which a spermatid transforms into a functional spermatozoon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

 MP:0013655 decreased CD103-positive CD11b-low dendritic cell number "reduction in the number of CD11b-low dendritic cells expressing CD103, a marker of tissue residency" [MGI:Saran, PMID:23516985]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014767 Tbp / P29037 / TATA box binding protein / P20226*  / reaction / complex
 ENSMUSG00000024382 Ercc3 / P49135 / TFIIH basal transcription factor complex helicase XPB subunit / P19447* / ERCC excision repair 3, TFIIH core complex helicase subunit*  / reaction
 ENSMUSG00000067995 Gtf2f2 / Q8R0A0 / ral transcription factor IIF subunit 2 / P13984* / general transcription factor IIF subunit 2*  / reaction / complex
 ENSMUSG00000028271 Gtf2b / P62915 / Transcription initiation factor IIB / Q00403* / general transcription factor IIB*  / reaction / complex
 ENSMUSG00000022828 Gtf2e1 / Q9D0D5 / Mus musculusral transcription factor II E, polypeptide 1 (alpha subunit) (Gtf2e1), transcript variant 2, mRNA. / P29083* / general transcription factor IIE subunit 1*  / complex / reaction
 ENSMUSG00000032185 Carm1 / Q9WVG6 / Histone-arginine methyltransferase CARM1 / Q86X55* / coactivator associated arginine methyltransferase 1*  / complex / reaction
 ENSMUSG00000031585 Gtf2e2 / Q9D902 / ral transcription factor IIE subunit 2 / P29084* / general transcription factor IIE subunit 2*  / reaction / complex
 ENSMUSG00000002658 Gtf2f1 / Q3THK3 / ral transcription factor IIF subunit 1 / P35269* / general transcription factor IIF subunit 1*  / reaction / complex
 ENSMUSG00000020962 Gtf2a1 / Q99PM3 / Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA alpha chain Transcription initiation factor IIA beta chain / P52655* / general transcript...  / complex
 ENSMUSG00000033543 Gtf2a2 / Q80ZM7 / Transcription initiation factor IIA subunit 2 / P52657* / general transcription factor IIA subunit 2*  / complex
 ENSMUSG00000109324 Prmt1 / Q9JIF0 / protein arginine N-methyltransferase 1 / Q99873* / protein arginine methyltransferase 1*  / reaction / complex
 ENSMUSG00000035451 Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*  / reaction / complex
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex / reaction
 ENSMUSG00000015619 Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*  / reaction / complex






 

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