ENSMUSG00000015619


Mus musculus

Features
Gene ID: ENSMUSG00000015619
  
Biological name :Gata3
  
Synonyms : Gata3 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23772
  
Possible biological names infered from orthology : GATA binding protein 3 / P23771
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A1
Gene start: 9857078
Gene end: 9890034
  
Corresponding Affymetrix probe sets: 10479981 (MoGene1.0st)   1448886_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100041
Ensembl peptide - ENSMUSP00000119730
NCBI entrez gene - 14462     See in Manteia.
MGI - MGI:95663
RefSeq - NM_008091
RefSeq - XM_006497355
RefSeq - NM_001355110
RefSeq - NM_001355111
RefSeq - NM_001355112
RefSeq - XM_006497354
RefSeq Peptide - NP_001342041
RefSeq Peptide - NP_032117
RefSeq Peptide - NP_001342039
RefSeq Peptide - NP_001342040
swissprot - P23772
swissprot - Q3U0R5
swissprot - F6QTY0
Ensembl - ENSMUSG00000015619
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gata3ENSDARG00000016526Danio rerio
 GATA3ENSGALG00000029270Gallus gallus
 GATA3ENSG00000107485Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gata2 / O09100 / Mus musculus GATA binding protein 2 (Gata2), transcript variant 2, mRNA. / P23769* / GATA binding protein 2*ENSMUSG0000001505367
Gata6 / Q61169 / Transcription factor GATA-6 / Q92908* / GATA binding protein 6*ENSMUSG0000000583633
Gata1 / P17679 / Erythroid transcription factor / P15976* / GATA binding protein 1*ENSMUSG0000003116233
Gata4 / Q08369 / Transcription factor GATA-4 / P43694* / GATA binding protein 4*ENSMUSG0000002194431
Gata5 / P97489 / Transcription factor GATA-5 / Q9BWX5* / GATA binding protein 5*ENSMUSG0000001562730
Trps1 / transcriptional repressor GATA binding 1 / Q9UHF7*ENSMUSG0000003867926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR013088  Zinc finger, NHR/GATA-type
 IPR016374  Transcription factor, GATA-2/3
 IPR029521  Transcription factor GATA-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001709 cell fate determination IDA
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001775 cell activation IMP
 biological_processGO:0001806 type IV hypersensitivity IEA
 biological_processGO:0001819 positive regulation of cytokine production IDA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001823 mesonephros development IMP
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002572 pro-T cell differentiation IMP
 biological_processGO:0003180 aortic valve morphogenesis IMP
 biological_processGO:0003215 cardiac right ventricle morphogenesis IMP
 biological_processGO:0003281 ventricular septum development IMP
 biological_processGO:0006338 chromatin remodeling IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006959 humoral immune response IMP
 biological_processGO:0007165 signal transduction IMP
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010975 regulation of neuron projection development IMP
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030217 T cell differentiation ISO
 biological_processGO:0030218 erythrocyte differentiation IDA
 biological_processGO:0031929 TOR signaling IMP
 biological_processGO:0032689 negative regulation of interferon-gamma production IMP
 biological_processGO:0032703 negative regulation of interleukin-2 production IDA
 biological_processGO:0032736 positive regulation of interleukin-13 production IMP
 biological_processGO:0032753 positive regulation of interleukin-4 production IMP
 biological_processGO:0032754 positive regulation of interleukin-5 production IMP
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0033600 negative regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0035457 cellular response to interferon-alpha IEA
 biological_processGO:0035799 ureter maturation IMP
 biological_processGO:0035898 parathyroid hormone secretion IMP
 biological_processGO:0042035 regulation of cytokine biosynthetic process IDA
 biological_processGO:0042421 norepinephrine biosynthetic process IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0043523 regulation of neuron apoptotic process IMP
 biological_processGO:0043583 ear development IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045061 thymic T cell selection IMP
 biological_processGO:0045064 T-helper 2 cell differentiation IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045582 positive regulation of T cell differentiation IEA
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0048485 sympathetic nervous system development IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048568 embryonic organ development IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IMP
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050852 T cell receptor signaling pathway IDA
 biological_processGO:0051569 regulation of histone H3-K4 methylation IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060017 parathyroid gland development IMP
 biological_processGO:0060037 pharyngeal system development IMP
 biological_processGO:0060065 uterus development IMP
 biological_processGO:0060231 mesenchymal to epithelial transition IEA
 biological_processGO:0060374 mast cell differentiation IDA
 biological_processGO:0060676 ureteric bud formation IMP
 biological_processGO:0061085 regulation of histone H3-K27 methylation IDA
 biological_processGO:0061290 canonical Wnt signaling pathway involved in metanephric kidney development IMP
 biological_processGO:0071345 cellular response to cytokine stimulus IDA
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071442 positive regulation of histone H3-K14 acetylation IMP
 biological_processGO:0071599 otic vesicle development IMP
 biological_processGO:0071773 cellular response to BMP stimulus IDA
 biological_processGO:0072001 renal system development IGI
 biological_processGO:0072107 positive regulation of ureteric bud formation IMP
 biological_processGO:0072178 nephric duct morphogenesis IMP
 biological_processGO:0072179 nephric duct formation IMP
 biological_processGO:0072182 regulation of nephron tubule epithelial cell differentiation IMP
 biological_processGO:0072602 interleukin-4 secretion IMP
 biological_processGO:0072643 interferon-gamma secretion IMP
 biological_processGO:0072676 lymphocyte migration IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:1901536 negative regulation of DNA demethylation IMP
 biological_processGO:2000114 regulation of establishment of cell polarity IDA
 biological_processGO:2000146 negative regulation of cell motility IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 biological_processGO:2000553 positive regulation of T-helper 2 cell cytokine production IMP
 biological_processGO:2000607 negative regulation of cell proliferation involved in mesonephros development IMP
 biological_processGO:2000611 positive regulation of thyroid hormone generation IEA
 biological_processGO:2000617 positive regulation of histone H3-K9 acetylation IMP
 biological_processGO:2000664 positive regulation of interleukin-5 secretion IEA
 biological_processGO:2000667 positive regulation of interleukin-13 secretion IEA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2000683 regulation of cellular response to X-ray IEA
 biological_processGO:2000703 negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation IMP
 biological_processGO:2000734 negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation IMP
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005134 interleukin-2 receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IDA
 molecular_functionGO:0070888 E-box binding IEA
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Amelxtm2Msnd/Amelx+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Trp53tm1Thst/Trp53+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * SJL

 MP:0000036 absent semicircular canals "missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Amelxtm2Msnd/Amelx+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Thst/Trp53+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * SJL

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dbsq3C57BLKS/J/Dbsq3C3H/HeJ,Leprdb/Lepr+
Genetic Background: involves: C3H/HeJ * C57BLKS

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
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Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000417 short hair "reduced average length of the hairs" [J:64948]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000422 delayed hair appearance "late onset of the first appearance of the fur" [J:17792]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(DO11.10)10Dlo/0,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata3tm2Jeng/Gata3tm2Jeng
Genetic Background: Not Specified

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gata3tm1Gsv/Gata3tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic Background: C.129S6-Cd1d1tm1Luc

Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(Dbh-cre/ERT2)198.1Hroh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(Dbh-cre/ERT2)198.1Hroh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001244 thin dermal layer "reduced thickness of the dermis" [J:65030]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gata3tm1.1Gan/Gata3tm1.1Gan,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
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Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001282 short vibrissae "decreased length of the vibrissae" [J:30249]
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Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic Background: C.129S6-Cd1d1tm1Luc

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic Background: C.129S6-Cd1d1tm1Luc

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(DO11.10)10Dlo/0,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abca4tm1Ght/Abca4tm1Ght
Genetic Background: involves: 129S4/SvJae

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Gata3jal/Gata3+
Genetic Background: C3H/HeJ-Gata3jal/J

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trpv1tm1Jul/Trpv1tm1Jul
Genetic Background: B6.129X1-Trpv1tm1Jul/J

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata3tm1Jfz/Gata3tm1Jfz,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Gata3tm1Jfz/Gata3tm1Jfz,Rag2tm1Fwa/Rag2tm1Fwa,Tg(Cd4-cre)1Cwi/0,Tg(Tcra5CC7,Tcrb5CC7)IWep/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Gata3tm2Jeng/Gata3tm2Jeng
Genetic Background: Not Specified

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata3tm1Jfz/Gata3tm1Jfz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata3tm2Jeng/Gata3tm2Jeng
Genetic Background: Not Specified

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata3tm1Jfz/Gata3tm1Jfz,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Gata3tm1Jfz/Gata3tm1Jfz,Tg(Tnfrsf4-cre)1Nik/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata3tm1Jfz/Gata3tm1Jfz,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Thst/Trp53+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * SJL

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Thst/Trp53+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * SJL

Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm1Jfz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002856 abnormal vestibular ganglion morphology "malformation of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Thst/Trp53+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * SJL

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Thst/Trp53+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL * SJL

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gata3tm1Gsv/Gata3tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0003148 reduced cochlear coiling "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gata3tm1Gsv/Gata3tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm1.1Gan/Gata3tm1.1Gan,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0003308 abnormal cochlear sensory epithelium 
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Allelic Composition: Gata3tm1Gsv/Gata3tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003810 abnormal hair cuticle "anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bsxtm2Aoh/Bsxtm2Aoh
Genetic Background: either: 129S4/SvJae-Bsxtm2Aoh or (involves: 129S4/SvJae * C57BL/6)

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd1d1tm1Luc/Cd1d1tm1Luc
Genetic Background: C.129S6-Cd1d1tm1Luc

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004249 abnormal crista ampullaris morphology "anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass" [J:60193, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1.1Gan/Gata3tm1.1Gan,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0004310 small otic vesicle "reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1Gsv/Gata3tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0004315 absent saccule "absence of the smaller of the two sacs in the vestibule " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1Gsv/Gata3tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dbsq3C57BLKS/J/Dbsq3C3H/HeJ,Leprdb/Lepr+
Genetic Background: involves: C3H/HeJ * C57BLKS

 MP:0004369 absent utricle "absence of the larger of the two sacs in the vestibule" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1Gsv/Gata3tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dbsq3C57BLKS/J/Dbsq3C3H/HeJ,Leprdb/Lepr+
Genetic Background: involves: C3H/HeJ * C57BLKS

 MP:0004399 abnormal cochlear outer hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Gata3tm1Gsv/Gata3+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0004405 absent cochlear hair cells "absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1.1Gan/Gata3tm1.1Gan,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0004408 decreased cochlear hair cell number "decreased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1.1Gan/Gata3tm1.1Gan,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0004465 degeneration of supporting cells "degeneration or loss of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1Gsv/Gata3+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0004497 decreased supporting cell number "decreased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1.1Gan/Gata3tm1.1Gan,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0004562 abnormal inner hair cell synaptic ribbon morphology "any structural abnormality in the presynaptic active zone of mature cochlear IHCs which usually contain a single synaptic ribbon, i.e. a submicrometer, electron-dense structure tethering synaptic vesicles; each spiral ganglion neuron receives input from only one IHC synapse" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004586 pillar cell degeneration "degeneration or loss of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1Gsv/Gata3+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0004664 delayed inner ear development "slowed progression to structurally mature components of the labyrinth, including the semicircular canals, vestibule and cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1Gsv/Gata3tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm1Yql/Grin1tm1Yql,Rgs9tm1(cre)Yql/Rgs9+
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1Gsv/Gata3+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0004861 abnormal Raphe nucleus morphology "any structural anomaly of the subgroup of the reticular nuclei of the brain stem that are located in and along the median plane of the medulla oblongata, pons, and mesencephalon that include neurons that synthesize serotonin and extend ascending fibers to parts of the limbic system and descending fibers to other brain stem nuclei, the medulla oblongata, and the pons" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0004923 absent common crus "absence of the united, nonampullary ends of the superior and posterior semicircular ducts in the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1Gsv/Gata3tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Il13tm1(YFP/cre)Lky/Il13+
Genetic Background: involves: 129S4/SvJae

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata3tm1Jfz/Gata3tm1Jfz,Tg(Tnfrsf4-cre)1Nik/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Il13tm1(YFP/cre)Lky/Il13+
Genetic Background: involves: 129S4/SvJae

 MP:0005072 abnormal hair follicle melanin granule "anomalous pigment paricles in the hair follicles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gata3tm2Jeng/Gata3tm2Jeng
Genetic Background: Not Specified

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(DO11.10)10Dlo/0,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0006011 abnormal endolymphatic duct morphology "any structural alteration in the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gata3tm1Gsv/Gata3tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0006030 abnormal otic vesicle formation "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Gata3tm1Gsv/Gata3tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gata3tm1.1Gan/Gata3tm1.1Gan,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006286 inner ear hypoplasia "underdevelopment or reduced size of inner ear structures, usually due to decreased cell number" [J:83662, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1.1Gan/Gata3tm1.1Gan,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0006287 inner ear cysts "abnormal membranous sacs in any component of the labyrinth, including the semicircular canals, vestibule and cochlea" [J:111415, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1Gsv/Gata3tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm2Jeng/Gata3tm2Jeng
Genetic Background: Not Specified

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Gata3tm1Jfz/Gata3tm1Jfz,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(DO11.10)10Dlo/0,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0,Tg(DO11.10)10Dlo/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * DBA/2

 MP:0008077 abnormal CD8-positive T cell number "anomaly in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(DO11.10)10Dlo/0,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
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Allelic Composition: Gata3tm1Jfz/Gata3tm1Jfz,Tg(Tnfrsf4-cre)1Nik/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008091 decreased T-helper 2 cell number "reduction in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1Jfz/Gata3tm1Jfz,Tg(Tnfrsf4-cre)1Nik/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Gata3tm2Jeng/Gata3tm2Jeng
Genetic Background: Not Specified

 MP:0008487 abnormal mesonephros morphology "any structural anomaly of the excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop" [MESH:A16.254.500]
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Allelic Composition: Bsxtm2Aoh/Bsxtm2Aoh
Genetic Background: either: 129S4/SvJae-Bsxtm2Aoh or (involves: 129S4/SvJae * C57BL/6)

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Gata3tm1Jfz/Gata3tm1Jfz,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Myctm2Fwa/Myctm2Fwa,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008733 abnormal hair shaft melanin granule distribution "disruption in the regular arrangement of pigment polymers in the hair shaft" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009073 absent Wolffian ducts "absence of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsxtm2Aoh/Bsxtm2Aoh
Genetic Background: either: 129S4/SvJae-Bsxtm2Aoh or (involves: 129S4/SvJae * C57BL/6)

 MP:0009284 abnormal sympathetic neuron innervation "defective or incomplete supply of nerve fibers to sympathetic termini" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(Dbh-cre/ERT2)198.1Hroh/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009733 absent nipple "absence of the erectile projection at the apex of the mammary gland where the lactiferous ducts open" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009861 abnormal pyloric sphincter morphology "any structural anomaly of the thick circular layer of gastric musculature encircling the gastroduodenal junction at the gastric outlet of the stomach" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gli3tm3.1Blnw/Gli3tm3.1Blnw,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

 MP:0010070 decreased serotonin concentration "reduction in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0010202 focal dorsal hair loss "focal hair loss on the dorsal area of a rodent resulting in dorsal skin visible in a patch where hair loss occurs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:Sanger_Karp "Submission from Natasha Karp"]
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Allelic Composition: Ppp3r1tm2Grc/Ppp3r1tm2.1Grc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010684 abnormal hair follicle outer root sheath morphology "any structural anomaly of the outermost layer of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [PMID:19211055]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010685 abnormal hair follicle inner root sheath morphology "any structural anomaly of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle s layer, Huxley s layer and the inner root sheath cuticle" [PMID:19211055]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010690 thick hair follicle outer rooth sheath "increased thickness of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010780 abnormal stomach smooth muscle circular layer morphology "any structural anomaly of the middle layer of the muscularis; it is continuous with the circular layer of the esophagus, but is absent in the fundus and lies concentric to the longitudinal axis of the stomach; the circular layer is normally tonically constricted forming a functional pyloric sphincter, which controls the movement of chyme into the duodenum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli3tm3.1Blnw/Gli3tm3.1Blnw,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

 MP:0010805 abnormal stomach smooth muscle outer longitudinal layer morphology "any structural anomaly of the most superficial layer of the muscularis; it has two sections, a longitudinal layer that is common with the esophagus and ends in the corpus, and a longitudinal layer that originates in the corpus and spreads into the duodenum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli3tm3.1Blnw/Gli3tm3.1Blnw,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

 MP:0010978 absent ureteric bud "absence of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308]
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Allelic Composition: Bsxtm2Aoh/Bsxtm2Aoh
Genetic Background: either: 129S4/SvJae-Bsxtm2Aoh or (involves: 129S4/SvJae * C57BL/6)

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gata3tm1.1Gan/Gata3tm1.1Gan,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gata3tm1Gsv/Gata3tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm2Gsv/Gata3tm2Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Gata3tm1.2Mbu/Gata3tm1.2Mbu
Genetic Background: C3.129P2-Gata3tm1.2Mbu

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Itpkbtm1Ssch/Itpkbtm1Ssch,Itpkctm1Ssch/Itpkctm1Ssch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011238 abnormal inner ear development "atypical initial production, differentiation, migration or maturation of the labyrinth, including the semicircular canals, vestibule and cochlea" [MGI:llw2]
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Allelic Composition: Gata3tm1.1Gan/Gata3tm1.1Gan,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6Ncr

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Gata3tm1Gsv/Gata3+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0013781 abnormal mammary gland luminal epithelium morphology "any structural anomaly of the inner cell layer of the mammary epithelium bilayer that lines the luminal surface of mammary gland ducts and alveoli; luminal cells have only limited contact with the underlying basement membrane and surrounding connective tissue; they are secretory epithelial cells characterized by the expression of the receptors for systemic hormones, i.e. estrogens, progesterone and prolactin" [http://umr144.curie.fr/en/research-groups/molecular-mechanisms-mammary-gland-development-marina-glukhova/molecular-mechanisms-, ISBN:8793237073, MGI:Anna]
Show

Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000109324 Prmt1 / Q9JIF0 / protein arginine N-methyltransferase 1 / Q99873* / protein arginine methyltransferase 1*  / reaction / complex
 ENSMUSG00000035451 Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*  / reaction / complex
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex / reaction
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex / reaction
 ENSMUSG00000014767 Tbp / P29037 / TATA box binding protein / P20226*  / complex / reaction
 ENSMUSG00000032185 Carm1 / Q9WVG6 / Histone-arginine methyltransferase CARM1 / Q86X55* / coactivator associated arginine methyltransferase 1*  / reaction / complex
 ENSMUSG00000033543 Gtf2a2 / Q80ZM7 / Transcription initiation factor IIA subunit 2 / P52657* / general transcription factor IIA subunit 2*  / reaction / complex
 ENSMUSG00000020962 Gtf2a1 / Q99PM3 / Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA alpha chain Transcription initiation factor IIA beta chain / P52655* / general transcript...  / complex / reaction
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction
 ENSMUSG00000021264 Yy1 / Q00899 / YY1 transcription factor / P25490*  / reaction
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000053483 Usp21 / ubiquitin specific peptidase 21 / Q9UK80*  / complex






 

1 s.

 
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