ENSMUSG00000015053


Mus musculus

Features
Gene ID: ENSMUSG00000015053
  
Biological name :Gata2
  
Synonyms : Gata2 / Mus musculus GATA binding protein 2 (Gata2), transcript variant 2, mRNA. / O09100
  
Possible biological names infered from orthology : GATA binding protein 2 / P23769
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: D1
Gene start: 88193891
Gene end: 88207032
  
Corresponding Affymetrix probe sets: 10539873 (MoGene1.0st)   1428816_a_at (Mouse Genome 430 2.0 Array)   1450333_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015197
Ensembl peptide - ENSMUSP00000128198
Ensembl peptide - ENSMUSP00000145503
NCBI entrez gene - 14461     See in Manteia.
MGI - MGI:95662
RefSeq - XM_006505539
RefSeq - NM_001355253
RefSeq - NM_008090
RefSeq Peptide - NP_001342182
RefSeq Peptide - NP_032116
swissprot - O09100
swissprot - Q3U320
swissprot - A0A0N4SWF9
Ensembl - ENSMUSG00000015053
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gata2aENSDARG00000059327Danio rerio
 GATA2ENSGALG00000005909Gallus gallus
 GATA2ENSG00000179348Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*ENSMUSG0000001561962
Gata1 / P17679 / Erythroid transcription factor / P15976* / GATA binding protein 1*ENSMUSG0000003116232
Gata6 / Q61169 / Transcription factor GATA-6 / Q92908* / GATA binding protein 6*ENSMUSG0000000583631
Gata5 / P97489 / Transcription factor GATA-5 / Q9BWX5* / GATA binding protein 5*ENSMUSG0000001562729
Gata4 / Q08369 / Transcription factor GATA-4 / P43694* / GATA binding protein 4*ENSMUSG0000002194428
Trps1 / transcriptional repressor GATA binding 1 / Q9UHF7*ENSMUSG0000003867922


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR013088  Zinc finger, NHR/GATA-type
 IPR016374  Transcription factor, GATA-2/3
 IPR029522  Transcription factor GATA-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001655 urogenital system development IMP
 biological_processGO:0001709 cell fate determination IDA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0006351 transcription, DNA-templated ISO
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0010725 regulation of primitive erythrocyte differentiation IGI
 biological_processGO:0021514 ventral spinal cord interneuron differentiation IMP
 biological_processGO:0021533 cell differentiation in hindbrain IMP
 biological_processGO:0021902 commitment of neuronal cell to specific neuron type in forebrain IMP
 biological_processGO:0021954 central nervous system neuron development IMP
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0035065 regulation of histone acetylation IDA
 biological_processGO:0035854 eosinophil fate commitment IEA
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0043306 positive regulation of mast cell degranulation IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IMP
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IDA
 biological_processGO:0045650 negative regulation of macrophage differentiation IDA
 biological_processGO:0045654 positive regulation of megakaryocyte differentiation IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0060100 positive regulation of phagocytosis, engulfment IEA
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0060872 semicircular canal development IMP
 biological_processGO:0070345 negative regulation of fat cell proliferation IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:0097154 GABAergic neuron differentiation IMP
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 biological_processGO:2000977 regulation of forebrain neuron differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070742 C2H2 zinc finger domain binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm4Sho/Y,Gata2tm2Sho/Gata2tm2Sho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gata2tm3.1Sho/Gata2tm3.1Sho
Genetic Background: B6.129S1-Gata2tm3.1Sho

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000516 abnormal urinary system morphology "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Gata2tm1.1Ebres/Gata2+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Gata2tm1.1Ebres/Gata2+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Fustm1.1(KOMP)Vlcg/Fustm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fustm1.1(KOMP)Vlcg/Ucd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata2tm1.1Sac/Gata2tm1.1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gata2tm3.1Sho/Gata2tm3.1Sho
Genetic Background: B6.129S1-Gata2tm3.1Sho

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gata2tm1.1Sac/Gata2tm1.1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001746 abnormal pituitary secretion "altered ability of the pituitary to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata2tm1.1Sac/Gata2tm1.1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Gata2tm1.1Ebres/Gata2+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gata2tm1.1Ebres/Gata2+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm2Gsc/Creb1+
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

Allelic Composition: Gata2tm1Mym/Gata2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Rxratm1Krc/Rxratm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

Allelic Composition: Gata2tm2.1Ebres/Gata2tm2.1Ebres
Genetic Background: involves: C57BL/6

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata1tm4Sho/Y,Gata2tm2Sho/Gata2tm2Sho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm2Gsc/Creb1+
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fustm1.1(KOMP)Vlcg/Fustm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fustm1.1(KOMP)Vlcg/Ucd

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gata2tm1.1Sac/Gata2tm1.1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gata2tm1.1Ebres/Gata2+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gata2tm3.1Sho/Gata2tm3.1Sho
Genetic Background: B6.129S1-Gata2tm3.1Sho

 MP:0003245 abnormal GABA neuron morphology "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003585 large ureter "increased size or length of the tube that conducts the urine from the renal pelvis to the bladder" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003672 abnormal ureter development "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003816 abnormal pituitary gland development "malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:51160]
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Allelic Composition: Gata2tm1.1Sac/Gata2tm1.1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003877 abnormal serotonergic neuron morphology "malformation or absence of the neurons that secrete serotonin" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54240]
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Allelic Composition: En1tm2(cre)Wrst/En1+,Gata2tm1Msal/Gata2tm1Msal
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004727 absent epididymis "absence of the elongated structure connected to the posterior surface of the testis, consisting of the head, body, and tail, which turns sharply on itself to become the ductus deferens (vas deferens)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fustm1.1(KOMP)Vlcg/Fustm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fustm1.1(KOMP)Vlcg/Ucd

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

Allelic Composition: Gata2tm1.1Ebres/Gata2tm1.1Ebres
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata2tm1.1Sac/Gata2tm1.1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005119 decreased circulating thyroid-stimulating hormone level "less than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gata2tm1.1Sac/Gata2tm1.1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata2tm4.1Sho/Gata2tm4.1Sho
Genetic Background: Not Specified

Allelic Composition: Gata2tm1.1Ebres/Gata2+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

Allelic Composition: Gata2tm1.1Ebres/Gata2tm1.1Ebres
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata2tm3.1Sho/Gata2tm3.1Sho
Genetic Background: B6.129S1-Gata2tm3.1Sho

Allelic Composition: Gata2tm1.1Ebres/Gata2+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

Allelic Composition: Gata2tm1.1Ebres/Gata2tm1.1Ebres
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0009489 abnormal blood vessel endothelium morphology "any structural anomaly of the thin layer of flat cells that line the blood vessels and form a barrier between circulating blood in the lumen and the rest of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gata2tm1.1Ebres/Gata2tm1.1Ebres
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: En1tm2(cre)Wrst/En1+,Gata2tm1Msal/Gata2tm1Msal
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gata1tm4Sho/Y,Gata2tm2Sho/Gata2tm2Sho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Gata2tm1.1Sac/Gata2tm1.1Sac
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Hand1tm1Jcc/Hand1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata2tm1Mym/Gata2tm1Mym
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gata2tm1.1Ebres/Gata2tm1.1Ebres
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Irs1tm2Tka/Irs1tm2Tka,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Fustm1.1(KOMP)Vlcg/Fustm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fustm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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