ENSMUSG00000031162


Mus musculus

Features
Gene ID: ENSMUSG00000031162
  
Biological name :Gata1
  
Synonyms : Erythroid transcription factor / Gata1 / P17679
  
Possible biological names infered from orthology : GATA binding protein 1 / P15976
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A1.1
Gene start: 7959260
Gene end: 7978071
  
Corresponding Affymetrix probe sets: 10603417 (MoGene1.0st)   1449232_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033502
Ensembl peptide - ENSMUSP00000123620
Ensembl peptide - ENSMUSP00000118052
NCBI entrez gene - 14460     See in Manteia.
MGI - MGI:95661
RefSeq - NM_008089
RefSeq - XM_011247448
RefSeq Peptide - NP_032115
swissprot - B1AUB4
swissprot - P17679
swissprot - B1AUB3
Ensembl - ENSMUSG00000031162
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gata1aENSDARG00000013477Danio rerio
 gata1bENSDARG00000059130Danio rerio
 GATA1ENSG00000102145Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gata2 / O09100 / Mus musculus GATA binding protein 2 (Gata2), transcript variant 2, mRNA. / P23769* / GATA binding protein 2*ENSMUSG0000001505337
Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*ENSMUSG0000001561936
Gata6 / Q61169 / Transcription factor GATA-6 / Q92908* / GATA binding protein 6*ENSMUSG0000000583632
Gata4 / Q08369 / Transcription factor GATA-4 / P43694* / GATA binding protein 4*ENSMUSG0000002194431
Gata5 / P97489 / Transcription factor GATA-5 / Q9BWX5* / GATA binding protein 5*ENSMUSG0000001562730
Trps1 / transcriptional repressor GATA binding 1 / Q9UHF7*ENSMUSG0000003867923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR013088  Zinc finger, NHR/GATA-type
 IPR029524  Transcription factor GATA-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007267 cell-cell signaling IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010559 regulation of glycoprotein biosynthetic process IMP
 biological_processGO:0010724 regulation of definitive erythrocyte differentiation IDA
 biological_processGO:0010725 regulation of primitive erythrocyte differentiation IGI
 biological_processGO:0030099 myeloid cell differentiation IMP
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030219 megakaryocyte differentiation IEA
 biological_processGO:0030220 platelet formation IEA
 biological_processGO:0030221 basophil differentiation IEA
 biological_processGO:0030222 eosinophil differentiation IEA
 biological_processGO:0030502 negative regulation of bone mineralization IMP
 biological_processGO:0033690 positive regulation of osteoblast proliferation IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0035854 eosinophil fate commitment IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048468 cell development IMP
 biological_processGO:0048821 erythrocyte development IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IGI
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0070527 platelet aggregation IMP
 biological_processGO:0071733 transcriptional activation by promoter-enhancer looping IDA
 biological_processGO:0097028 dendritic cell differentiation IDA
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEA
 biological_processGO:2000678 negative regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008301 DNA binding, bending IDA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070742 C2H2 zinc finger domain binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: AtraidGt(OST23679)Lex/Atraid+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm1Sho/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Sho/Gata1tm1Sho,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT stock * Swiss albino

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Best1tm1.1Amar/Best1+
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Gata1tm1Sho/Gata1tm1Sho,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dp(16Cbr1-Fam3b)1Rhr/0,Gata1tm8.2Sho/Y
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0000228 abnormal thrombopoiesis "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata1Plt13/Y
Genetic Background: BALB/c-Gata1Plt13

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*V205G)1Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata1tm4Sho/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2.1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2.1Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*V205G)1Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gata1Plt13/Gata1+
Genetic Background: BALB/c-Gata1Plt13

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Dp(16Cbr1-Fam3b)1Rhr/0,Gata1tm8.2Sho/Y
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Gata1tm1Phi/Gata1+,Tg(HBB-cre)1Phi/0,Tg(HBB-Gata1)G4Phi/0
Genetic Background: involves: FVB

Allelic Composition: Gata1tm1Phi/Gata1+,Tg(HBB-cre)1Phi/0
Genetic Background: involves: FVB

Allelic Composition: Gata1tm1Phi/Gata1+,Tg(HBB-Gata1)G4Phi/0
Genetic Background: involves: FVB

Allelic Composition: Gata1tm7Sho/Gata1tm7Sho
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gata1tm7Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gata1tm8.2Sho/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gata1tm8.2Sho/Gata1tm8.2Sho
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gata1tm4Sho/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gata1tm4Sho/Y,Gata2tm2Sho/Gata2tm2Sho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gata1tm5(GATA3)Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*V205G)1Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Gata1tm1.1Yen/Gata1tm1.1Yen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Gata1tm5(GATA3)Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre/ERT)1Ipc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Gata1tm7Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gata1tm8.2Sho/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gata1tm8.2Sho/Gata1tm8.2Sho
Genetic Background: involves: 129S1/Sv

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Slc16a2tm1.1Sref/Slc16a2tm1.1Sref
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Ebf2tm1Reed/Ebf2+,Ebf3tm1Reed/Ebf3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gata1tm7Sho/Gata1tm7Sho
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gata1tm7Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gata1tm8.2Sho/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gata1tm8.2Sho/Gata1tm8.2Sho
Genetic Background: involves: 129S1/Sv

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gata1Plt13/Gata1+
Genetic Background: BALB/c-Gata1Plt13

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Dp(16Cbr1-Fam3b)1Rhr/0,Gata1tm8.2Sho/Y
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hexatm1Rlp/Hexatm1Rlp,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm1Mym/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Gata1tm1Phi/Gata1+,Tg(HBB-cre)1Phi/0,Tg(HBB-Gata1)G4Phi/0
Genetic Background: involves: FVB

Allelic Composition: Gata1tm1Phi/Gata1+,Tg(HBB-cre)1Phi/0
Genetic Background: involves: FVB

Allelic Composition: Gata1Plt13/Y
Genetic Background: BALB/c-Gata1Plt13

Allelic Composition: Gata1tm4Sho/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gata1tm5(GATA3)Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm5(GATA3)Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Dp(16Cbr1-Fam3b)1Rhr/0,Gata1tm8.2Sho/Y
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Gata1Plt13/Y
Genetic Background: BALB/c-Gata1Plt13

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Gdf11tm1Sjl/Gdf11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Gata1tm1Mym/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Gata1Plt13/Y
Genetic Background: BALB/c-Gata1Plt13

Allelic Composition: Gata1tm5(GATA3)Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Gata1tm1Mym/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Gata1tm1Mym/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Gata1tm5(GATA3)Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm5(GATA3)Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001770 abnormal iron level "anomalous concentrations of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcyt2tm1.1Suja/Pcyt2tm1.1Suja,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Gata1tm5(GATA3)Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT stock * Swiss albino

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-Bs/Kit+
Genetic Background: C57BL/6J

Allelic Composition: Gata1tm1Phi/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Gata1tm1Phi/Y,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002267 abnormal bronchiole morphology "any structural anomaly of the conducting airway of the lungs found terminal to the bronchi. These structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Gdf5bp-H/Gdf5bp-H
Genetic Background: involves: PCT stock * Swiss albino

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

Allelic Composition: Dp(16Cbr1-Fam3b)1Rhr/0,Gata1tm8.2Sho/Y
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm7Sho/Gata1tm7Sho
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gata1tm7Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gata1Plt13/Gata1+
Genetic Background: BALB/c-Gata1Plt13

Allelic Composition: Gata1tm4Sho/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gata1tm4Sho/Y,Gata2tm2Sho/Gata2tm2Sho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2.1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2.1Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm1Sho/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Sho/Gata1tm1Sho,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Dp(16Cbr1-Fam3b)1Rhr/0,Gata1tm8.2Sho/Y
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gata1tm8.1Sho/Gata1tm8.1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gata1tm8.1Sho/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gata1Plt13/Gata1+
Genetic Background: BALB/c-Gata1Plt13

Allelic Composition: Gata1tm8.2Sho/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gata1tm8.2Sho/Gata1tm8.2Sho
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2.1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*V205G)1Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*V205G)1Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002596 abnormal hematocrit "greater or less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2.1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*V205G)1Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm1Sho/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Sho/Gata1tm1Sho,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gata1tm5(GATA3)Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm1Sho/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Sho/Gata1tm1Sho,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gata1Plt13/Gata1+
Genetic Background: BALB/c-Gata1Plt13

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2.1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*V205G)1Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0003405 abnormal platelet shape 
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata1tm5(GATA3)Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm5(GATA3)Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*V205G)1Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1Plt13/Gata1+
Genetic Background: BALB/c-Gata1Plt13

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*V205G)1Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm1Mym/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*V205G)1Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1Plt13/Gata1+
Genetic Background: BALB/c-Gata1Plt13

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hexatm1Rlp/Hexatm1Rlp,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gata1tm6Sho/Y
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm2(tTA)Xz/Slc6a3+,Tg(tetO-COX8A/PstI*)1Ctm/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata1tm1Sho/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Sho/Gata1tm1Sho,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Dp(16Cbr1-Fam3b)1Rhr/0,Gata1tm8.2Sho/Y
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0008247 abnormal mononuclear leukocyte morphology "any structural anomaly of a leukocyte with a single non-segmented nucleus in the mature form" [CL:0000842]
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Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*V205G)1Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Gata1Plt13/Gata1+
Genetic Background: BALB/c-Gata1Plt13

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2.1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2.1Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm1Sho/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Sho/Gata1tm1Sho,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*V205G)1Mym/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Dp(16Cbr1-Fam3b)1Rhr/0,Gata1tm8.2Sho/Y
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0008477 decreased spleen red pulp amount "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0008609 decreased circulating interleukin-13 level "reduction in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gata1tm5(GATA3)Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008801 abnormal erythroid progenitor cell morphology "any structural anomaly of a progenitor cell committed to the erythroid lineage" [CL:0000038]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm1Mym/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Gata1tm10Sho/Y
Genetic Background: involves: C57BL/6

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm1Mym/Gata1tm1Mym,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1Mym/Y,Tg(Gata1*)#Mym/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2J

Allelic Composition: Gata1tm1.1Yen/Gata1tm1.1Yen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast,Gata1tm1.1Yen/Gata1tm1.1Yen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009246 pale spleen "spleen lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm1Mym/Gata1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0009676 abnormal hemostasis "any anomaly in the spontaneous arrest of bleeding from vessels carrying blood under pressure or the arrest of circulation to an organ or part" [MESH:G09.188.124.560, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0010178 increased number of Howell-Jolly bodies "abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010964 increased compact bone volume 
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Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gata1tm4Sho/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gata1tm4Sho/Y,Gata2tm2Sho/Gata2tm2Sho
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gata1tm1Mym/Y
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Gata1tm5(GATA3)Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gata1tm1Phi/Gata1+,Tg(HBB-cre)1Phi/0,Tg(HBB-Gata1)G4Phi/0
Genetic Background: involves: FVB

Allelic Composition: Gata1Plt13/Y
Genetic Background: BALB/c-Gata1Plt13

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gata1Plt13/Y
Genetic Background: BALB/c-Gata1Plt13

Allelic Composition: Gata1tm4Sho/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gata1tm5(GATA3)Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gata1tm5(GATA3)Sho/Gata1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011747 myelofibrosis "appearance of fibrous connective tissue in the bone marrow, often resulting from inflammation or injury; especially replacement of the marrow with collagenous connective tissue fibers, frequently accompanied by splenomegaly and anemia or cytopenias" [ISBN:0-683-40008-8]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Gata1Plt13/Y
Genetic Background: BALB/c-Gata1Plt13

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Gata1tm2Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000049577 Zfpm1 / O35615 / zinc finger protein, multitype 1 / Q8IX07* / zinc finger protein, FOG family member 1*  / complex






 

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