ENSMUSG00000021944


Mus musculus

Features
Gene ID: ENSMUSG00000021944
  
Biological name :Gata4
  
Synonyms : Gata4 / Q08369 / Transcription factor GATA-4
  
Possible biological names infered from orthology : GATA binding protein 4 / P43694
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 63198922
Gene end: 63271692
  
Corresponding Affymetrix probe sets: 10420747 (MoGene1.0st)   1418863_at (Mouse Genome 430 2.0 Array)   1418864_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113891
Ensembl peptide - ENSMUSP00000121008
Ensembl peptide - ENSMUSP00000114369
Ensembl peptide - ENSMUSP00000114279
Ensembl peptide - ENSMUSP00000066927
Ensembl peptide - ENSMUSP00000113451
NCBI entrez gene - 14463     See in Manteia.
MGI - MGI:95664
RefSeq - NM_008092
RefSeq - XM_011244957
RefSeq - XM_011244956
RefSeq - NM_001310610
RefSeq Peptide - NP_001297539
RefSeq Peptide - NP_032118
swissprot - D3YTQ2
swissprot - Q08369
swissprot - Q3UYJ1
swissprot - A4K4Z6
swissprot - E9PXW9
Ensembl - ENSMUSG00000021944
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gata4ENSDARG00000098952Danio rerio
 GATA4ENSGALG00000016662Gallus gallus
 GATA4ENSG00000136574Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gata6 / Q61169 / Transcription factor GATA-6 / Q92908* / GATA binding protein 6*ENSMUSG0000000583649
Gata5 / P97489 / Transcription factor GATA-5 / Q9BWX5* / GATA binding protein 5*ENSMUSG0000001562742
Gata2 / O09100 / Mus musculus GATA binding protein 2 (Gata2), transcript variant 2, mRNA. / P23769* / GATA binding protein 2*ENSMUSG0000001505331
Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*ENSMUSG0000001561931
Gata1 / P17679 / Erythroid transcription factor / P15976* / GATA binding protein 1*ENSMUSG0000003116229
Trps1 / transcriptional repressor GATA binding 1 / Q9UHF7*ENSMUSG0000003867924


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR008013  GATA-type transcription activator, N-terminal
 IPR013088  Zinc finger, NHR/GATA-type
 IPR016375  Transcription factor GATA-4/5/6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0001706 endoderm formation IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003151 outflow tract morphogenesis TAS
 biological_processGO:0003181 atrioventricular valve morphogenesis IGI
 biological_processGO:0003190 atrioventricular valve formation IGI
 biological_processGO:0003192 mitral valve formation TAS
 biological_processGO:0003195 tricuspid valve formation TAS
 biological_processGO:0003197 endocardial cushion development IEA
 biological_processGO:0003215 cardiac right ventricle morphogenesis IMP
 biological_processGO:0003229 ventricular cardiac muscle tissue development IGI
 biological_processGO:0003279 cardiac septum development IGI
 biological_processGO:0003281 ventricular septum development IMP
 biological_processGO:0003289 atrial septum primum morphogenesis IMP
 biological_processGO:0003290 atrial septum secundum morphogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0007267 cell-cell signaling IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IGI
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IMP
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IDA
 biological_processGO:0030509 BMP signaling pathway IDA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0032526 response to retinoic acid IDA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035054 embryonic heart tube anterior/posterior pattern specification IMP
 biological_processGO:0035239 tube morphogenesis IGI
 biological_processGO:0035914 skeletal muscle cell differentiation NAS
 biological_processGO:0036302 atrioventricular canal development IGI
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043627 response to estrogen IDA
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0045787 positive regulation of cell cycle IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048557 embryonic digestive tract morphogenesis IMP
 biological_processGO:0048598 embryonic morphogenesis IMP
 biological_processGO:0048617 embryonic foregut morphogenesis IMP
 biological_processGO:0048738 cardiac muscle tissue development IGI
 biological_processGO:0051891 positive regulation of cardioblast differentiation IEP
 biological_processGO:0051896 regulation of protein kinase B signaling IDA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0060008 Sertoli cell differentiation IMP
 biological_processGO:0060043 regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IGI
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0060290 transdifferentiation IEA
 biological_processGO:0060395 SMAD protein signal transduction IDA
 biological_processGO:0060413 atrial septum morphogenesis IEA
 biological_processGO:0060425 lung morphogenesis TAS
 biological_processGO:0060464 lung lobe formation IMP
 biological_processGO:0060540 diaphragm morphogenesis TAS
 biological_processGO:0060575 intestinal epithelial cell differentiation IEA
 biological_processGO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS
 biological_processGO:0061026 cardiac muscle tissue regeneration IDA
 biological_processGO:0061049 cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071371 cellular response to gonadotropin stimulus IDA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IDA
 biological_processGO:0072148 epithelial cell fate commitment IMP
 biological_processGO:0072520 seminiferous tubule development IMP
 biological_processGO:0086004 regulation of cardiac muscle cell contraction IEA
 biological_processGO:1903202 negative regulation of oxidative stress-induced cell death IDA
 biological_processGO:1905204 negative regulation of connective tissue replacement IDA
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IDA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051525 NFAT protein binding IEA
 molecular_functionGO:0070410 co-SMAD binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Xbp1tm3Glm/Xbp1tm3Glm,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata4tm1Wtp/Gata4tm1Wtp
Genetic Background: involves: 129 * C57BL/6

 MP:0000270 abnormal heart tube morphology "malformed embryonic heart " [J:37888]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Gabra6tm2(cre)Wwis/Gabra6+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata4tm1Grg/Gata4tm1Grg
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Gata4tm1Wtp/Gata4tm1Wtp
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata4tm1Wtp/Gata4tm1Wtp
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: FVB/N

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Gata4tm1Grg/Gata4tm1.1Wtp,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000301 reduced size of endocardial cushions "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Agttm1Ii/Agt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Xbp1tm3Glm/Xbp1tm3Glm,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Gata4tm1Sho/Gata4tm1Sho,Gata6tm1Kgac/Gata6tm1Kgac
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Tg(Myh7-cre)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Tg(Myh6-Map2k1*)1Jmol/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gata4tm1.2Wtp/Gata4tm1.2Wtp
Genetic Background: involves: 129 * C57BL/6

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Rettm1Cos/Ret+,Wnt11tm1Amc/Wnt11tm1Amc
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001942 abnormal lung volume "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gabra6tm2(cre)Wwis/Gabra6+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rettm1Cos/Ret+,Wnt11tm1Amc/Wnt11tm1Amc
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rettm1Cos/Ret+,Wnt11tm1Amc/Wnt11tm1Amc
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Grg/Gata4tm1.1Wtp,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Wtp/Gata4tm1Wtp
Genetic Background: involves: 129 * C57BL/6

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Wtp/Gata4tm1Wtp
Genetic Background: involves: 129 * C57BL/6

 MP:0002211 abnormal primary sex determination "aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gata4tm1Grg/Gata4tm1Grg
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gata4tm1Grg/Gata4tm1.1Wtp,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
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Allelic Composition: Agttm1Ii/Agt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: FVB/N

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gabra6tm2(cre)Wwis/Gabra6+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002995 primary sex reversal "gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Grg/Gata4tm1Grg
Genetic Background: involves: 129 * C57BL/6

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata4tm1Wtp/Gata4tm1Wtp
Genetic Background: involves: 129 * C57BL/6

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Tg(Myh7-cre)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Wtp/Gata4tm1Wtp
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: FVB/N

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Tg(Myh7-cre)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cd40lgtm1Imx/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gata4tm1.2Wtp/Gata4+
Genetic Background: B6.Cg-Gata4tm1.2Wtp

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.2Sad,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gata4tm1Grg/Gata4tm1Grg
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gata4tm1Grg/Gata4tm1.1Wtp,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129 * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1.2Wtp/Gata4+
Genetic Background: B6.Cg-Gata4tm1.2Wtp

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Wtp/Gata4tm1Wtp
Genetic Background: involves: 129 * C57BL/6

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004067 abnormal ventricular trabeculae morphology "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004187 cardia bifida "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004225 patent foramen ovale "incomplete closure of the atrial septum after birth, resulting in a flap or a valve-like opening in the atrial septal wall" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Grg/Gata4tm1Grg
Genetic Background: involves: 129 * C57BL/6

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.1Jmol/Gata4tm1.1Jmol
Genetic Background: involves: 129 * C57BL/6

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.1Jmol/Gata4tm1.1Jmol
Genetic Background: involves: 129 * C57BL/6

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Tg(Myh7-cre)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Pax3Sp/Pax3+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gabra6tm2(cre)Wwis/Gabra6+,Mfn2tm1Dcc/Mfn2tm3Dcc
Genetic Background: involves: 129 * 129S4/SvJaeSor * Black Swiss

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Tg(Myh6-cre)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Tg(Myh7-cre)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Gata4tm1.1Jmol/Gata4tm1.1Jmol
Genetic Background: involves: 129 * C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005406 abnormal heart size "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata4tm1.1Jmol/Gata4tm1.1Jmol
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gata4tm1.1Jmol/Gata4tm1.1Jmol,Tg(Myh6-Map2k1*)1Jmol/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Xbp1tm3Glm/Xbp1tm3Glm,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0006046 atrioventricular valve insufficiency "the atrioventricular valves do not close tightly enough to prevent leakage" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Gata4tm1Wtp/Gata4tm1Wtp
Genetic Background: involves: 129 * C57BL/6

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0006128 pulmonary valve stenosis "abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Grg/Gata4tm1Grg
Genetic Background: involves: 129 * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
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Allelic Composition: Cacnb4lh-2J/Cacnb4lh-2J
Genetic Background: involves: C3H * C57BL/6 * DBA/2J

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
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Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009328 delayed heart looping "late onset of the initiation and/or completion of cardiac looping" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Grg/Gata4tm1Grg
Genetic Background: involves: 129 * C57BL/6

 MP:0009865 abnormal aorta smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Gata4tm1.2Wtp/Gata4+
Genetic Background: B6.Cg-Gata4tm1.2Wtp

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata4tm1Grg/Gata4+
Genetic Background: involves: 129 * C57BL/6

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010408 sinus venosus atrial septal defect "interatrial communication (atrial septal defect) through the upper atrial septum and that is contiguous with the superior vena cava (SVC); it is rostral and posterior to the fossa ovalis (where secundum type defects occur) and is separate from it" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Gata4tm1.2Wtp/Gata4+
Genetic Background: B6.Cg-Gata4tm1.2Wtp

 MP:0010413 complete atrioventricular septal defect "a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]
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Allelic Composition: Gata4tm1Wtp/Gata4tm1Wtp
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010419 inlet ventricular septal defect "abnormal communications between the two lower chambers of the heart, located posterior to the septal leaflet of the tricuspid valve and which are not associated with defects of the atrioventricular valves" [http://emedicine.medscape.com]
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Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010422 heart right ventricle hypoplasia "underdevelopment or reduced size of the heart right ventricle, often due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010428 abnormal heart right ventricle outflow tract morphology "any structural anomaly of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010429 abnormal heart left ventricle outflow tract morphology "any structural anomaly of the anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010432 common ventricle "the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010454 abnormal truncus arteriosis septation "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

 MP:0010463 aorta stenosis "diffuse constriction or narrowing of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Grg/Gata4+
Genetic Background: involves: 129 * C57BL/6

 MP:0010485 aortic arch hypoplasia "underdevelopment or reduced size of the aortic arch, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0010541 aorta hypoplasia "underdevelopment or reduced size of the main trunk of the systemic arterial system that originates from the base of the left ventricle of the heart and extends to the abdomen at the point where it branches into the common iliac arteries, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0010545 abnormal heart layer morphology "any structural anomaly of the laminar structure of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gata4tm1.1Sad/Gata4+,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0010556 thin ventricle myocardium compact layer "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gata4tm1Grg/Gata4+
Genetic Background: involves: 129 * C57BL/6

 MP:0010561 absent coronary vessels "absence of the arteries and veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

 MP:0010574 aorta dilation "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0010585 abnormal conotruncal ridge morphology "any structural anomaly of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

 MP:0010587 conotruncal ridge hypoplasia "underdevelopment or reduced size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]
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Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010594 thick aortic valve "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Grg/Gata4+
Genetic Background: involves: 129 * C57BL/6

 MP:0010601 thick pulmonary valve "an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Grg/Gata4+
Genetic Background: involves: 129 * C57BL/6

 MP:0010607 common atrioventricular valve "the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

 MP:0010640 ventricular myocardium compact layer hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.2Wtp/Gata4+
Genetic Background: B6.Cg-Gata4tm1.2Wtp

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.2Wtp/Gata4+
Genetic Background: B6.Cg-Gata4tm1.2Wtp

 MP:0010975 abnormal lung lobe morphology "any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.2Sad,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gata4tm1.2Wtp/Gata4+
Genetic Background: B6.Cg-Gata4tm1.2Wtp

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Ehmt1Tg(Tyr)2265COve/Ehmt1Tg(Tyr)2265COve
Genetic Background: FVB/N-Ehmt1Tg(Tyr)2265COve

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata4tm1.1Sho/Gata4tm1.1Sho
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gata4tm1Grg/Gata4tm1Grg
Genetic Background: involves: 129 * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gata4tm1Wtp/Gata4tm1Wtp
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gata4tm1.2Wtp/Gata4tm1.2Wtp
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gata4tm1.1Wtp/Gata4tm1.1Wtp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: FVB/N

Allelic Composition: Gata4tm1Jml/Gata4+,Gata5tm1Eem/Gata5tm1Eem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Gata4tm1Grg/Gata4tm1.1Wtp,Tg(Nkx2-5-cre)9Eno/0
Genetic Background: involves: 129 * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gata4tm1.1Sad/Gata4+,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011112 partial lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tor1atm2Wtd/Tor1atm2Wtd
Genetic Background: involves: 129S1/Sv * CD-1

 MP:0011200 abnormal extraembryonic coelom morphology "any structural anomaly of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity" [ISBN:0-12-402035-6, ISBN-10:1405118660]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011235 abnormal blood oxygen capacity "the maximum amount of oxygen that will combine chemically with a given amount of hemoglobin in a unit volume of blood is not as expected" [ISBN:0-683-40008-8]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.2Sad,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0011388 absent heart "absence of the hollow, muscular organ that maintains the circulation of the blood" [MGI:smb]
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Allelic Composition: Cacnb4lh-2J/Cacnb4lh-2J
Genetic Background: involves: C3H * C57BL/6 * DBA/2J

 MP:0011395 decreased fetal cardiomyocyte proliferation "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Gata4tm1Grg/Gata4tm1Grg
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gata4tm1Grg/Gata4+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0012061 abnormal central tendon morphology "any structural anomaly of the three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers" [MGI:csmith]
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Allelic Composition: Gata4tm1.2Wtp/Gata4+
Genetic Background: B6.Cg-Gata4tm1.2Wtp

 MP:0012081 absent heart tube "absence of the primitive epithelial cardiac tube before the division into the chambers of the mature heart" [MGI:anna]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl,Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
Genetic Background: either: B6.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk or C.Cg-Cd28tm1Pjl Tnfrsf9tm1Byk

Allelic Composition: Gata4tm1.2Sad/Gata4tm1.2Sad,Gata6tm3.1Sad/Gata6tm3.1Sad
Genetic Background: involves: 129

 MP:0012083 absent foregut "absence of the anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder" [MGI:anna]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012185 abnormal muscle precursor cell morphology "any structural anomaly of cells that will develop into muscle cells" [MGI:mnk]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.2Sad,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0012186 abnormal muscle precursor cell physiology "anomaly in the function of cells that will develop into muscle cells" [MGI:mnk]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.2Sad,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0012251 abnormal diaphragm development "malformation or incomplete differentiation of the thin musculomembranous barrier separating the abdominal and thoracic cavities and functioning in respiration" [MGI:anna]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.2Sad,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0012278 abnormal cardiogenic mesoderm morphology "any structural anomaly of the splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium" [MGI:anna]
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Allelic Composition: Gata4tm1.2Sad/Gata4tm1.2Sad,Gata6tm3.1Sad/Gata6tm3.1Sad
Genetic Background: involves: 129

 MP:0013006 abnormal enteric neural crest cell migration "any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise predominantly from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7, and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; NCCs are termed enteric neural crest-derived cells upon entering the foregut at E9-9.5 in mice (after 4 weeks gestation in humans) and the colonization process is complete by E15.5 (after 7 weeks gestation in humans)" [MGI:anna, PMID:17514199]
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Pax3Sp/Pax3+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0013603 abnormal fetal Leydig cell differentiation "atypical formation of or inability to produce the first or fetal population of Leydig cells (FLCs); in mice, FLCs arise in the testicular interstitium between E12.5 and E13.0, approximately 1 day after the appearance of Sertoli cells; Sertoli cells trigger differentiation of steroidogenic factor 1-positive (SF1-positive) progenitor cells into FLCs via paracrine regulation; the intercellular Notch signaling pathway is also involved in FLC establishment and maintenance; the FLC population increases dramatically during embryonic development despite the fact that differentiating FLCs are mitotically inactive, suggesting that expansion of FLC populations results from differentiation of progenitor cells, rather than cell division of existing FLCs; the SF1-positive cells in gonadal primordia are the primary source of FLCs but other sources such as neighboring mesonephros, migrating neural crest cells, and cells from the coelomic epithelium or interstitium are potential contributors also; at the end of fetal life and during the first 2 postnatal weeks in rodents, FLCs are gradually replaced by adult Leydig cells (ALCs)" [PMID:23568777]
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Allelic Composition: Gata4tm1Sho/Gata4tm1Sho
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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