MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Trps1tm1.1Shiv/Trps1+ Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
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MP:0000069 | kyphoscoliosis | "kyphosis combined with scoliosis" [MGI:CML, J:66943] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000088 | short mandible | "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Raratm3Ipc/Rara+,Speer6-ps1Tg(Alb-cre)21Mgn/?,Trim24tm1Los/Trim24tm1Los Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL
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MP:0000097 | short maxilla | "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Raratm3Ipc/Rara+,Speer6-ps1Tg(Alb-cre)21Mgn/?,Trim24tm1Los/Trim24tm1Los Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL
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MP:0000150 | abnormal rib morphology | "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000161 | scoliosis | "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000166 | abnormal chondrocyte morphology | "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203] |
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Allelic Composition: Raratm3Ipc/Rara+,Speer6-ps1Tg(Alb-cre)21Mgn/?,Trim24tm1Los/Trim24tm1Los Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL
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MP:0000377 | abnormal hair follicle | "malformed invagination of the epidermis from which the hair shaft develops" [J:65031] |
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Allelic Composition: Raratm3Ipc/Rara+,Speer6-ps1Tg(Alb-cre)21Mgn/?,Trim24tm1Los/Trim24tm1Los Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL
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MP:0000379 | reduced hair follicle number | "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Trps1tm1.1Shiv/Trps1+ Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0000416 | sparse fur | "fur that is significantly less dense" [J:46854] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000480 | increased number of ribs | "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000527 | abnormal kidney development | "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
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Allelic Composition: Raratm3Ipc/Rara+,Speer6-ps1Tg(Alb-cre)21Mgn/?,Trim24tm1Los/Trim24tm1Los Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL
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MP:0001177 | atelectasis | "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0001179 | thicker alveolar septa | |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0001216 | abnormal epidermal layer morphology | "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: H2dlAb1-Ea/H2dlAb1-Ea,Rag1tm1Mom/Rag1tm1Mom,Tg(HLA-DRA,HLA-DRB5*0101)loKito/0,Tg(TRATL3A6,TRBTL3A6)#Kito/0 Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
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MP:0001284 | absent vibrissae | "missing whiskers" [J:18378] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0001505 | hunched posture | "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0001575 | cyanosis | "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0001953 | respiratory failure | "cessation of or failure to commence breathing" [MGI:cls, J:60159] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0002270 | abnormal alveoli morphology | "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0002273 | abnormal alveolar epithelial cell morphology | "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0002282 | abnormal trachea morphology | "structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Raratm3Ipc/Rara+,Speer6-ps1Tg(Alb-cre)21Mgn/?,Trim24tm1Los/Trim24tm1Los Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL
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MP:0002427 | dwarfism | "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Raratm3Ipc/Rara+,Speer6-ps1Tg(Alb-cre)21Mgn/?,Trim24tm1Los/Trim24tm1Los Genetic Background: involves: 129/Sv * C57BL/6 * DBA * SJL
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MP:0002639 | micrognathia | "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0003419 | delayed endochondral bone ossification | "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0003641 | small lung | "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0003704 | abnormal hair follicle development | "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0003761 | arched palate | "abnormally concaved shape to the roof of the oral cavity" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Trps1tm1.1Shiv/Trps1+ Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
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MP:0004320 | split sternum | "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0004321 | short sternum | "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0004505 | decreased renal glomerulus number | "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0004553 | absent tracheal cartilage rings | "absence of the 16-20 incomplete rings of hyaline cartilage forming the skeleton of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0004624 | abnormal thoracic cage | "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0004674 | thin ribs | "a more slender appearance of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0004686 | decreased length of long bones | "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0008271 | abnormal bone ossification | "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0008277 | abnormal sternum ossification | "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0010099 | abnormal thoracic cage shape | "anomaly in the overall regular dome shape of the ribcage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0010103 | small thoracic cage | "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0010981 | abnormal branching involved in ureteric bud morphogenesis | "anomaly in the process in which the branching structure of the ureteric bud is generated and organized" [GO:0001658] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0010984 | abnormal metanephric mesenchyme morphology | "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Trps1tm1Shiv/Trps1tm1Shiv Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0011290 | decreased nephron number | "reduction in the total number of filtering units of the kidney" [MGI:anna] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0011425 | abnormal kidney interstitium morphology | "any structural anomaly of the kidney region located between the nephrons, ureteric epithelia (ureteric tips, trunk and collecting duct system) and renal vasculature, and composed of renal support cells, including fibroblasts and macrophages, and mesenchymal stroma or interstitial cells; the renal vasculature lies within the renal interstitium but is not a part of it; various conditions can lead to scarring (fibrosis) and congestion of this area, which can cause kidney dysfunction and failure" [MGI:anna] |
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Allelic Composition: Trps1tm1Ymur/Trps1tm1Ymur Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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