ENSMUSG00000005836


Mus musculus

Features
Gene ID: ENSMUSG00000005836
  
Biological name :Gata6
  
Synonyms : Gata6 / Q61169 / Transcription factor GATA-6
  
Possible biological names infered from orthology : GATA binding protein 6 / Q92908
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A1
Gene start: 11052510
Gene end: 11085635
  
Corresponding Affymetrix probe sets: 10453857 (MoGene1.0st)   1425463_at (Mouse Genome 430 2.0 Array)   1425464_at (Mouse Genome 430 2.0 Array)   1443081_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041774
NCBI entrez gene - 14465     See in Manteia.
MGI - MGI:107516
RefSeq - NM_010258
RefSeq - XM_017317834
RefSeq Peptide - NP_034388
swissprot - Q61169
Ensembl - ENSMUSG00000005836
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gata6ENSDARG00000103589Danio rerio
 GATA6ENSGALG00000014976Gallus gallus
 GATA6ENSG00000141448Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gata4 / Q08369 / Transcription factor GATA-4 / P43694* / GATA binding protein 4*ENSMUSG0000002194437
Gata5 / P97489 / Transcription factor GATA-5 / Q9BWX5* / GATA binding protein 5*ENSMUSG0000001562732
Gata2 / O09100 / Mus musculus GATA binding protein 2 (Gata2), transcript variant 2, mRNA. / P23769* / GATA binding protein 2*ENSMUSG0000001505325
Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*ENSMUSG0000001561924
Gata1 / P17679 / Erythroid transcription factor / P15976* / GATA binding protein 1*ENSMUSG0000003116222
Trps1 / transcriptional repressor GATA binding 1 / Q9UHF7*ENSMUSG0000003867920


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR008013  GATA-type transcription activator, N-terminal
 IPR013088  Zinc finger, NHR/GATA-type
 IPR016375  Transcription factor GATA-4/5/6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0003148 outflow tract septum morphogenesis IEA
 biological_processGO:0003309 type B pancreatic cell differentiation IMP
 biological_processGO:0003310 pancreatic A cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006644 phospholipid metabolic process IGI
 biological_processGO:0007493 endodermal cell fate determination IDA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IMP
 biological_processGO:0030513 positive regulation of BMP signaling pathway IBA
 biological_processGO:0030855 epithelial cell differentiation IMP
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0032911 negative regulation of transforming growth factor beta1 production IEA
 biological_processGO:0032912 negative regulation of transforming growth factor beta2 production IEA
 biological_processGO:0035239 tube morphogenesis IGI
 biological_processGO:0035987 endodermal cell differentiation IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043627 response to estrogen IDA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048645 animal organ formation IMP
 biological_processGO:0048738 cardiac muscle tissue development IGI
 biological_processGO:0051145 smooth muscle cell differentiation IEA
 biological_processGO:0051891 positive regulation of cardioblast differentiation IEP
 biological_processGO:0055007 cardiac muscle cell differentiation IEP
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IGI
 biological_processGO:0060430 lung saccule development IGI
 biological_processGO:0060486 Clara cell differentiation IGI
 biological_processGO:0060510 type II pneumocyte differentiation IGI
 biological_processGO:0060575 intestinal epithelial cell differentiation IEA
 biological_processGO:0060947 cardiac vascular smooth muscle cell differentiation IEA
 biological_processGO:0070848 response to growth factor IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:0071371 cellular response to gonadotropin stimulus IDA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071773 cellular response to BMP stimulus IDA
 biological_processGO:0110024 positive regulation of cardiac muscle myoblast proliferation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IPI
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Surfactant metabolism
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

Allelic Composition: Gata6tm2Msp/Gata6tm2Msp,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Prrx1-cre)1Cjt/0,Tg(tetO-Gata6)1Abl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Gata6tm2.1Sad/Gata6tm2.1Sad,Shhtm2Amc/Shhtm2Amc,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Aw-43J/?
Genetic Background: involves: C57BL/6J

Allelic Composition: Gata6tm1Msp/Gata6+,Nkx2-1tm1Shk/Nkx2-1+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Gata6tm1Gsv/Gata6tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

Allelic Composition: Gata6tm1Msp/Gata6tm1Msp
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vsx2or-J/Vsx2or-J,Modor3CASA/Rk/?
Genetic Background: involves: 129S1/Sv * CASA/Rk

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

Allelic Composition: Gata6tm2Msp/Gata6tm2Msp,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata6tm1Msp/Gata6tm1Msp
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

Allelic Composition: Gata6tm2Msp/Gata6tm2Msp,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

Allelic Composition: Gata6tm2Msp/Gata6tm2Msp,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata6tm1Msp/Gata6+,Nkx2-1tm1Shk/Nkx2-1+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
Show

Allelic Composition: Cacnb4lh-2J/Cacnb4lh-2J
Genetic Background: involves: C3H * C57BL/6 * DBA/2J

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
Show

Allelic Composition: Cyp11b2tm1.1(cre)Brlt/Cyp11b2+,Nr5a1tm2Klp/Nr5a1tm2Klp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0009865 abnormal aorta smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
Show

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

Allelic Composition: Gata6tm2Msp/Gata6tm2Msp,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010485 aortic arch hypoplasia "underdevelopment or reduced size of the aortic arch, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

Allelic Composition: Gata6tm2Msp/Gata6tm2Msp,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0010541 aorta hypoplasia "underdevelopment or reduced size of the main trunk of the systemic arterial system that originates from the base of the left ventricle of the heart and extends to the abdomen at the point where it branches into the common iliac arteries, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0010545 abnormal heart layer morphology "any structural anomaly of the laminar structure of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gata4tm1.1Sad/Gata4+,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010565 absent fetal ductus arteriosus "absence of the fetal vessel that connects the left pulmonary artery with the descending aorta" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0010574 aorta dilation "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0010814 absent alveolar lamellar bodies "absence of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata6tm1Msp/Gata6+,Nkx2-1tm1Shk/Nkx2-1+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata6tm1Msp/Gata6+,Nkx2-1tm1Shk/Nkx2-1+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1

 MP:0010898 abnormal pulmonary alveolus epithelium morphology "any structural anomaly of the epithelial layer of the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata6tm1Msp/Gata6+,Nkx2-1tm1Shk/Nkx2-1+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1

 MP:0010993 decreased surfactant secretion "decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata6tm1Msp/Gata6+,Nkx2-1tm1Shk/Nkx2-1+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gata6tm1Msp/Gata6+,Nkx2-1tm1Shk/Nkx2-1+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

Allelic Composition: Gata6tm2Msp/Gata6tm2Msp,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gata6tm2.1Sad/Gata6tm2.2Sad,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL

Allelic Composition: Gata6tm2Sad/Gata6tm2Sad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Gata6tm1Msp/Gata6tm1Msp
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Gata6tm1Gsv/Gata6tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

Allelic Composition: Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Gata6tm2.1Sad/Gata6tm2.2Sad,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL

Allelic Composition: Gata4tm1Eno/Gata4+,Gata6tm1Eno/Gata6+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4+,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
Show

Allelic Composition: Gata6tm1Msp/Gata6+,Nkx2-1tm1Shk/Nkx2-1+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1

 MP:0011183 abnormal primitive endoderm morphology "any structural anomaly of the monolayer of cells derived from and located on the surface of inner cell mass, directly facing the blastocoele, and is separated from the more centrally located epiblast by basal lamina; the primitive endoderm give rises to the visceral endoderm and the parietal endoderm" [PMID:21123814]
Show

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011185 absent primitive endoderm "absence of the monolayer of cells derived from and located on the surface of inner cell mass, directly facing the blastocoele, and is separated from the more centrally located epiblast by basal lamina; the primitive endoderm give rises to the visceral endoderm and the parietal endoderm" [PMID:21123814]
Show

Allelic Composition: G0s2tm1Jgte/G0s2tm1Jgte
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gata6tm2.2Sad/Gata6tm2.2Sad,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

Allelic Composition: Gata6tm2.2Sad/Gata6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011189 small embryonic epiblast "reduced size of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Gata6tm1Msp/Gata6tm1Msp
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0011191 increased embryonic epiblast cell apoptosis "increase in the number of embryonic epiblast cells undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Gata6tm1Msp/Gata6tm1Msp
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

 MP:0011388 absent heart "absence of the hollow, muscular organ that maintains the circulation of the blood" [MGI:smb]
Show

Allelic Composition: Cacnb4lh-2J/Cacnb4lh-2J
Genetic Background: involves: C3H * C57BL/6 * DBA/2J

 MP:0011395 decreased fetal cardiomyocyte proliferation "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6tm2.1Sad,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0012081 absent heart tube "absence of the primitive epithelial cardiac tube before the division into the chambers of the mature heart" [MGI:anna]
Show

Allelic Composition: Cacnb4lh-2J/Cacnb4lh-2J
Genetic Background: involves: C3H * C57BL/6 * DBA/2J

 MP:0012113 decreased inner cell mass proliferation 
Show

Allelic Composition: Gata6tm1Gsv/Gata6tm1Gsv
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)

 MP:0012235 abnormal liver bud morphology "any structural anomaly of the liver primordium formed as hepatoblasts delaminate from the anterior portion of the hepatic diverticulum and invade the adjacent septum transversum mesenchyme" [MGI:anna]
Show

Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

 MP:0012278 abnormal cardiogenic mesoderm morphology "any structural anomaly of the splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium" [MGI:anna]
Show

Allelic Composition: Gata4tm1.2Sad/Gata4tm1.2Sad,Gata6tm3.1Sad/Gata6tm3.1Sad
Genetic Background: involves: 129

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Gata6tm1Msp/Gata6tm1Msp
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057604 Lmcd1 / Q8VEE1 / LIM and cysteine-rich domains 1 / Q9NZU5*  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr