ENSDARG00000103589


Danio rerio

Features
Gene ID: ENSDARG00000103589
  
Biological name :gata6
  
Synonyms : gata6 / GATA binding protein 6
  
Possible biological names infered from orthology : Q61169 / Q92908 / Transcription factor GATA-6
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 4207209
Gene end: 4217887
  
Corresponding Affymetrix probe sets: Dr.8293.1.S1_at (Zebrafish Array)   NM_131557_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000137653
Ensembl peptide - ENSDARP00000129963
Ensembl peptide - ENSDARP00000136299
NCBI entrez gene - 58076     See in Manteia.
RefSeq - NM_131557
RefSeq - NM_001326364
RefSeq - XM_017358955
RefSeq - XM_017358958
RefSeq Peptide - NP_571632
RefSeq Peptide - NP_001313293
swissprot - Q6NW63
swissprot - A0A0R4IB15
ZFIN ID - ZDB-GENE-000622-1
Ensembl - ENSDARG00000103589
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GATA6ENSGALG00000014976Gallus gallus
 GATA6ENSG00000141448Homo sapiens
 Gata6ENSMUSG00000005836Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gata5 / GATA binding protein 5 / P97489* / Q9BWX5* / Transcription factor GATA-5 *ENSDARG0000001782136
gata4 / GATA binding protein 4 / P43694* / Q08369* / Transcription factor GATA-4 *ENSDARG0000009895236
gata3 / Q91428 / GATA binding protein 3 / P23771* / P23772* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*ENSDARG0000001652629
gata2b / GATA binding protein 2bENSDARG0000000909427
gata2a / GATA binding protein 2a / GATA2* / O09100* / P23769* / GATA binding protein 2* / Mus musculus GATA binding protein 2 (Gata2), transcript variant 2, mRNA.*ENSDARG0000005932727
gata1a / GATA binding protein 1a / GATA1* / P17679* / P15976* / GATA binding protein 1* / Erythroid transcription factor *ENSDARG0000001347726
gata1b / GATA binding protein 1b / GATA1* / P17679* / P15976* / GATA binding protein 1* / Erythroid transcription factor *ENSDARG0000005913025
trps1 / trichorhinophalangeal syndrome I / Q9UHF7* / transcriptional repressor GATA binding 1*ENSDARG0000010408220


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR008013  GATA-type transcription activator, N-terminal
 IPR013088  Zinc finger, NHR/GATA-type
 IPR016375  Transcription factor GATA-4/5/6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030099 myeloid cell differentiation IGI
 biological_processGO:0030513 positive regulation of BMP signaling pathway IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0060975 cardioblast migration to the midline involved in heart field formation IGI
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005667 transcription factor complex IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Surfactant metabolism
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000076 swim bladder swim bladder non-functional , abnormal
Show

 ZFA:0000112 gut gut deformed , abnormal
gut immature , abnormal
Show

 ZFA:0000114 heart heart hypoplastic , abnormal
Show

 ZFA:0000360 heart tube heart tube malformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002002 lmcd1 / LIM and cysteine-rich domains 1 / Q8VEE1* / Q9NZU5*  / reaction / complex






 

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