ENSDARG00000059327


Danio rerio

Features
Gene ID: ENSDARG00000059327
  
Biological name :gata2a
  
Synonyms : gata2a / GATA binding protein 2a
  
Possible biological names infered from orthology : GATA2 / GATA binding protein 2 / Mus musculus GATA binding protein 2 (Gata2), transcript variant 2, mRNA. / O09100 / P23769
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 3847442
Gene end: 3865472
  
Corresponding Affymetrix probe sets: Dr.356.1.S1_at (Zebrafish Array)   NM_131233_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000136014
Ensembl peptide - ENSDARP00000076855
Ensembl peptide - ENSDARP00000076860
NCBI entrez gene - 30480     See in Manteia.
RefSeq - NM_131233
RefSeq - XM_009305781
RefSeq Peptide - NP_571308
swissprot - Q7T3G1
swissprot - A0A0R4IKY6
ZFIN ID - ZDB-GENE-980526-260
Ensembl - ENSDARG00000059327
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GATA2ENSGALG00000005909Gallus gallus
 GATA2ENSG00000179348Homo sapiens
 Gata2ENSMUSG00000015053Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gata3 / Q91428 / GATA binding protein 3 / P23771* / P23772* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*ENSDARG0000001652659
gata2b / GATA binding protein 2bENSDARG0000000909456
gata1a / GATA binding protein 1a / GATA1* / P17679* / P15976* / GATA binding protein 1* / Erythroid transcription factor *ENSDARG0000001347739
gata1b / GATA binding protein 1b / GATA1* / P17679* / P15976* / GATA binding protein 1* / Erythroid transcription factor *ENSDARG0000005913034
gata6 / GATA binding protein 6 / Q61169* / Q92908* / Transcription factor GATA-6 *ENSDARG0000010358929
gata5 / GATA binding protein 5 / P97489* / Q9BWX5* / Transcription factor GATA-5 *ENSDARG0000001782128
gata4 / GATA binding protein 4 / P43694* / Q08369* / Transcription factor GATA-4 *ENSDARG0000009895228
trps1 / trichorhinophalangeal syndrome I / Q9UHF7* / transcriptional repressor GATA binding 1*ENSDARG0000010408223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR013088  Zinc finger, NHR/GATA-type
 IPR016374  Transcription factor, GATA-2/3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003190 atrioventricular valve formation IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0021514 ventral spinal cord interneuron differentiation IMP
 biological_processGO:0035912 dorsal aorta morphogenesis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0060215 primitive hemopoiesis IGI
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005667 transcription factor complex IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood decreased viscosity , abnormal
blood circulating cell decreased amount , abnormal
blood accumulation trunk vasculature , abnormal
Show

 ZFA:0000014 dorsal aorta dorsal aorta structure , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0001054 lateral dorsal aorta lateral dorsal aorta dilated , abnormal
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 ZFA:0001057 intersegmental vein intersegmental vein decreased length , abnormal
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 ZFA:0001256 lateral floor plate lateral floor plate Kolmer-Agduhr neuron undifferentiated , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature broken , abnormal
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 ZFA:0001315 atrioventricular canal atrioventricular canal decreased amount , abnormal
atrioventricular canal amount , ameliorated
atrioventricular canal blood circulation process quality , abnormal
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 ZFA:0001317 endocardial cushion endocardial cushion cell decreased amount , abnormal
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 ZFA:0001614 atrial endocardium atrial endocardium endothelial cell decreased amount , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature morphology , abnormal
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 ZFA:0005064 atrioventricular valve atrioventricular valve morphology , abnormal
atrioventricular valve absent , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte accumulation head , abnormal
nucleate erythrocyte accumulation trunk , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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