ENSDARG00000016526


Danio rerio

Features
Gene ID: ENSDARG00000016526
  
Biological name :gata3
  
Synonyms : gata3 / GATA binding protein 3 / Q91428
  
Possible biological names infered from orthology : Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771 / P23772
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 25054510
Gene end: 25064510
  
Corresponding Affymetrix probe sets: Dr.12584.1.S1_at (Zebrafish Array)   NM_131211_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000017572
NCBI entrez gene - 30458     See in Manteia.
RefSeq - XM_005164805
RefSeq - NM_131211
RefSeq Peptide - NP_571286
swissprot - Q91428
swissprot - B3DGG5
ZFIN ID - ZDB-GENE-990415-82
Ensembl - ENSDARG00000016526
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GATA3ENSGALG00000029270Gallus gallus
 GATA3ENSG00000107485Homo sapiens
 Gata3ENSMUSG00000015619Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gata2a / GATA binding protein 2a / GATA2* / O09100* / P23769* / GATA binding protein 2* / Mus musculus GATA binding protein 2 (Gata2), transcript variant 2, mRNA.*ENSDARG0000005932762
gata2b / GATA binding protein 2bENSDARG0000000909448
gata1a / GATA binding protein 1a / GATA1* / P17679* / P15976* / GATA binding protein 1* / Erythroid transcription factor *ENSDARG0000001347739
gata1b / GATA binding protein 1b / GATA1* / P17679* / P15976* / GATA binding protein 1* / Erythroid transcription factor *ENSDARG0000005913037
gata6 / GATA binding protein 6 / Q61169* / Q92908* / Transcription factor GATA-6 *ENSDARG0000010358933
gata5 / GATA binding protein 5 / P97489* / Q9BWX5* / Transcription factor GATA-5 *ENSDARG0000001782130
gata4 / GATA binding protein 4 / P43694* / Q08369* / Transcription factor GATA-4 *ENSDARG0000009895229
trps1 / trichorhinophalangeal syndrome I / Q9UHF7* / transcriptional repressor GATA binding 1*ENSDARG0000010408224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR013088  Zinc finger, NHR/GATA-type
 IPR016374  Transcription factor, GATA-2/3
 IPR029521  Transcription factor GATA-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IDA
 biological_processGO:0021514 ventral spinal cord interneuron differentiation IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0042246 tissue regeneration IMP
 biological_processGO:0043049 otic placode formation IGI
 biological_processGO:0045582 positive regulation of T cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048702 embryonic neurocranium morphogenesis IMP
 biological_processGO:0050769 positive regulation of neurogenesis IMP
 biological_processGO:0060788 ectodermal placode formation IGI
 biological_processGO:0061026 cardiac muscle tissue regeneration IMP
 biological_processGO:0071696 ectodermal placode development IMP
 biological_processGO:2001224 positive regulation of neuron migration IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005667 transcription factor complex IBA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens morphology , abnormal
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 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
anatomical structure decreased amount , abnormal
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 ZFA:0000048 olfactory placode olfactory placode spatial pattern , ameliorated
olfactory placode decreased distribution , abnormal
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 ZFA:0000051 otic vesicle otic vesicle hypoplastic , abnormal
otic vesicle has fewer parts of type hair cell , abnormal
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 ZFA:0000075 spinal cord spinal cord Kolmer-Agduhr neuron undifferentiated , abnormal
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 ZFA:0000130 olfactory pit olfactory pit morphology , abnormal
olfactory pit increased size , abnormal
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 ZFA:0000138 otic placode otic placode hypoplastic , abnormal
otic placode decreased amount , abnormal
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 ZFA:0000162 trigeminal placode trigeminal placode hypoplastic , abnormal
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 ZFA:0001107 internal gill bud internal gill bud decreased length , abnormal
internal gill bud decreased amount , abnormal
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 ZFA:0001198 adenohypophyseal placode adenohypophyseal placode increased size , abnormal
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 ZFA:0001269 regenerating fin regenerating fin cell proliferation decreased process quality , abnormal
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 ZFA:0001321 neurocranial trabecula neurocranial trabecula malformed , abnormal
neurocranial trabecula chondrocyte disorganized , abnormal
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 ZFA:0001580 neurocranium neurocranium lacks all parts of type neurocranial trabecula , abnormal
neurocranium has fewer parts of type neurocranial trabecula , abnormal
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 ZFA:0001624 pronephric distal late tubule pronephric distal late tubule decreased object quality , abnormal
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 ZFA:0001679 solid lens vesicle solid lens vesicle spatial pattern , ameliorated
solid lens vesicle decreased distribution , abnormal
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 ZFA:0005147 regenerating tissue regenerating tissue cell proliferation decreased process quality , abnormal
regenerating tissue neurogenesis decreased process quality , abnormal
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 ZFA:0007059 neurogenic field neurogenic field decreased amount , abnormal
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 ZFA:0007061 epibranchial field epibranchial field decreased distribution , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018698 carm1 / Q6DC04 / coactivator-associated arginine methyltransferase 1 / Q9WVG6* / Q86X55* / Histone-arginine methyltransferase CARM1 *  / reaction / complex
 ENSDARG00000014994 tbp / Q7SXL3 / TATA box binding protein / P20226* / P29037*  / reaction / complex
 ENSDARG00000018257 ncoa1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / reaction / complex
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex
 ENSDARG00000077404 ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / complex / reaction
 ENSDARG00000094280 usp21 / ubiquitin specific peptidase 21 / Q9UK80*  / complex
 ENSDARG00000010246 prmt1 / protein arginine methyltransferase 1 / Q99873* / Q9JIF0* / protein arginine N-methyltransferase 1*  / complex / reaction
 ENSDARG00000053685 gtf2a2 / general transcription factor IIA, 2 / P52657* / Q80ZM7* / general transcription factor IIA subunit 2* / Transcription initiation factor IIA subunit 2 *  / complex / reaction






 

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