ENSGALG00000029270


Gallus gallus

Features
Gene ID: ENSGALG00000029270
  
Biological name :GATA3
  
Synonyms : GATA3 / GATA-binding factor 3 / P23825
  
Possible biological names infered from orthology : GATA binding protein 3 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771 / P23772
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 4402132
Gene end: 4591692
  
Corresponding Affymetrix probe sets: Gga.744.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000058144
NCBI entrez gene - 419106     See in Manteia.
RefSeq - XM_015293418
RefSeq - NM_001008444
RefSeq - XM_015293337
RefSeq - XM_015293371
RefSeq - XM_015293289
RefSeq Peptide - NP_001008444
swissprot - P23825
Ensembl - ENSGALG00000029270
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gata3ENSDARG00000016526Danio rerio
 GATA3ENSG00000107485Homo sapiens
 Gata3ENSMUSG00000015619Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GATA2 / P23824 / GATA-binding factor 2 / O09100* / P23769* / GATA binding protein 2* / Mus musculus GATA binding protein 2 (Gata2), transcript variant 2, mRNA.*ENSGALG0000000590968
GATA4 / GATA binding protein 4 / P43694* / Q08369* / Transcription factor GATA-4 *ENSGALG0000001666231
GATA5 / transcription factor GATA-5 / P97489* / Q9BWX5* / GATA binding protein 5*ENSGALG0000000535230
GATA6 / transcription factor GATA-6 / Q61169* / Q92908* / GATA binding protein 6*ENSGALG0000001497628
TRPS1 / transcriptional repressor GATA binding 1 / Q9UHF7*ENSGALG0000003170020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR013088  Zinc finger, NHR/GATA-type
 IPR016374  Transcription factor, GATA-2/3
 IPR029521  Transcription factor GATA-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001709 cell fate determination IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001775 cell activation IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001823 mesonephros development IEA
 biological_processGO:0002088 lens development in camera-type eye IEA
 biological_processGO:0002572 pro-T cell differentiation IEA
 biological_processGO:0003180 aortic valve morphogenesis IEA
 biological_processGO:0003215 cardiac right ventricle morphogenesis IEA
 biological_processGO:0003281 ventricular septum development IEA
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006959 humoral immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010975 regulation of neuron projection development IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0031929 TOR signaling IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032703 negative regulation of interleukin-2 production IEA
 biological_processGO:0032736 positive regulation of interleukin-13 production IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IEA
 biological_processGO:0032754 positive regulation of interleukin-5 production IEA
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0033600 negative regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0035162 embryonic hemopoiesis IEA
 biological_processGO:0035457 cellular response to interferon-alpha IEA
 biological_processGO:0035799 ureter maturation IEA
 biological_processGO:0035898 parathyroid hormone secretion IEA
 biological_processGO:0042035 regulation of cytokine biosynthetic process IEA
 biological_processGO:0042421 norepinephrine biosynthetic process IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0042491 inner ear auditory receptor cell differentiation IEP
 biological_processGO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IEA
 biological_processGO:0043583 ear development IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045061 thymic T cell selection IEA
 biological_processGO:0045064 T-helper 2 cell differentiation IEA
 biological_processGO:0045582 positive regulation of T cell differentiation ISS
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0048485 sympathetic nervous system development IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IEA
 biological_processGO:0048872 homeostasis of number of cells IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0051569 regulation of histone H3-K4 methylation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060017 parathyroid gland development IEA
 biological_processGO:0060037 pharyngeal system development IEA
 biological_processGO:0060065 uterus development IEA
 biological_processGO:0060231 mesenchymal to epithelial transition IEA
 biological_processGO:0060374 mast cell differentiation IEA
 biological_processGO:0060676 ureteric bud formation IEA
 biological_processGO:0061085 regulation of histone H3-K27 methylation IEA
 biological_processGO:0061290 canonical Wnt signaling pathway involved in metanephric kidney development IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071442 positive regulation of histone H3-K14 acetylation IEA
 biological_processGO:0071599 otic vesicle development IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:0072001 renal system development IEA
 biological_processGO:0072107 positive regulation of ureteric bud formation IEA
 biological_processGO:0072178 nephric duct morphogenesis IEA
 biological_processGO:0072179 nephric duct formation IEA
 biological_processGO:0072182 regulation of nephron tubule epithelial cell differentiation IEA
 biological_processGO:0072602 interleukin-4 secretion IEA
 biological_processGO:0072643 interferon-gamma secretion IEA
 biological_processGO:0072676 lymphocyte migration IEA
 biological_processGO:1901536 negative regulation of DNA demethylation IEA
 biological_processGO:2000114 regulation of establishment of cell polarity IEA
 biological_processGO:2000146 negative regulation of cell motility IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 biological_processGO:2000553 positive regulation of T-helper 2 cell cytokine production IEA
 biological_processGO:2000607 negative regulation of cell proliferation involved in mesonephros development IEA
 biological_processGO:2000611 positive regulation of thyroid hormone generation IEA
 biological_processGO:2000617 positive regulation of histone H3-K9 acetylation IEA
 biological_processGO:2000664 positive regulation of interleukin-5 secretion IEA
 biological_processGO:2000667 positive regulation of interleukin-13 secretion IEA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2000683 regulation of cellular response to X-ray IEA
 biological_processGO:2000703 negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation IEA
 biological_processGO:2000734 negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005134 interleukin-2 receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004570 NCOA3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / reaction / complex
 ENSGALG00000020078 H3F3C / histone H3.2 / H3.Y* / H3F3B* / H3F3A* / Q6NXT2* / P84243* / P84244* / Histone H3.3 * / H3 histone family member 3B* / H3 histone family member 3A* / H3 histone family member 3C* /...  / complex / reaction
 ENSGALG00000016617 NCOA1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / reaction / complex
 ENSGALG00000011992 EP300 / E1A binding protein p300 / B2RWS6* / Q09472* / Histone acetyltransferase p300 *  / complex / reaction
 ENSGALG00000003793 GTF2A2 / general transcription factor IIA subunit 2 / P52657* / Q80ZM7* / Transcription initiation factor IIA subunit 2 *  / complex / reaction
 ENSGALG00000010576 GTF2A1 / general transcription factor IIA subunit 1 / P52655* / Q99PM3* / Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA alpha chain Transcription initiat...  / complex / reaction
 ENSGALG00000003297 HDAC1 / P56517 / Histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / reaction
 ENSGALG00000043062 P84229 / HIST2H3D / Histone H3.2 / Q71DI3* / histone cluster 2 H3 family member d*  / reaction / complex
 ENSGALG00000042491 P62801 / Histone H4   / reaction / complex
 ENSGALG00000011171 TBP / TATA-box-binding protein / P20226* / P29037*  / reaction / complex
 ENSGALG00000032713 FOXA1 / forkhead box A1 / P35582* / P55317* / Hepatocyte nuclear factor 3-alpha *  / reaction / complex






 

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