ENSGALG00000016617


Gallus gallus

Features
Gene ID: ENSGALG00000016617
  
Biological name :NCOA1
  
Synonyms : NCOA1 / nuclear receptor coactivator 1
  
Possible biological names infered from orthology : P70365 / Q15788
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 105921033
Gene end: 106086519
  
Corresponding Affymetrix probe sets: Gga.3317.1.S1_s_at (Chicken Array)   GgaAffx.10639.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050346
Ensembl peptide - ENSGALP00000026767
Ensembl peptide - ENSGALP00000026768
NCBI entrez gene - 422016     See in Manteia.
RefSeq - XM_015285107
RefSeq - NM_001012882
RefSeq - XM_015285104
RefSeq - XM_015285105
RefSeq - XM_015285106
RefSeq Peptide - NP_001012900
swissprot - F6UXS6
swissprot - A0A1D6UPT8
swissprot - Q5F393
Ensembl - ENSGALG00000016617
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncoa1ENSDARG00000018257Danio rerio
 NCOA1ENSG00000084676Homo sapiens
 Ncoa1ENSMUSG00000020647Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NCOA3 / nuclear receptor coactivator 3 / Q9Y6Q9*ENSGALG0000000457032
NCOA2* / Q15596* / Q61026* / nuclear receptor coactivator 2*ENSGALG0000003601715
NCOA2* / Q15596* / Q61026* / nuclear receptor coactivator 2*ENSGALG0000004599513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR009110  Nuclear receptor coactivator, interlocking
 IPR010011  Domain of unknown function DUF1518
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR014920  Nuclear receptor coactivator, Ncoa-type, interlocking
 IPR014935  Nuclear receptor coactivator, receptor-binding domain
 IPR017426  Nuclear receptor coactivator
 IPR028819  Nuclear receptor coactivator 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose IEA
 biological_processGO:0002155 regulation of thyroid hormone mediated signaling pathway IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IBA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060713 labyrinthine layer morphogenesis IEA
 biological_processGO:1904017 cellular response to Thyroglobulin triiodothyronine IEA
 biological_processGO:2001038 regulation of cellular response to drug IEA
 biological_processGO:2001141 regulation of RNA biosynthetic process IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016922 nuclear receptor binding IEA
 molecular_functionGO:0017162 aryl hydrocarbon receptor binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Endogenous sterols
HATs acetylate histones
SUMOylation of transcription cofactors
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000032713 FOXA1 / forkhead box A1 / P35582* / P55317* / Hepatocyte nuclear factor 3-alpha *  / complex / reaction
 ENSGALG00000011992 EP300 / E1A binding protein p300 / B2RWS6* / Q09472* / Histone acetyltransferase p300 *  / complex / reaction
 ENSGALG00000029270 GATA3 / P23825 / GATA-binding factor 3 / P23771* / P23772* / GATA binding protein 3* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000011171 TBP / TATA-box-binding protein / P20226* / P29037*  / complex / reaction
 ENSGALG00000010576 GTF2A1 / general transcription factor IIA subunit 1 / P52655* / Q99PM3* / Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA alpha chain Transcription initiat...  / complex / reaction
 ENSGALG00000003793 GTF2A2 / general transcription factor IIA subunit 2 / P52657* / Q80ZM7* / Transcription initiation factor IIA subunit 2 *  / reaction / complex
 ENSGALG00000011594 NR1H4 / nuclear receptor subfamily 1 group H member 4 / Q60641* / Q96RI1* / Bile acid receptor *  / reaction / complex






 

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