ENSDARG00000013477


Danio rerio

Features
Gene ID: ENSDARG00000013477
  
Biological name :gata1a
  
Synonyms : gata1a / GATA binding protein 1a
  
Possible biological names infered from orthology : Erythroid transcription factor / GATA1 / GATA binding protein 1 / P15976 / P17679
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 25411914
Gene end: 25418856
  
Corresponding Affymetrix probe sets: Dr.355.1.S1_at (Zebrafish Array)   NM_131234_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000002330
NCBI entrez gene - 30481     See in Manteia.
RefSeq - NM_131234
RefSeq Peptide - NP_571309
swissprot - Q05AJ3
ZFIN ID - ZDB-GENE-980526-268
Ensembl - ENSDARG00000013477
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GATA1ENSG00000102145Homo sapiens
 Gata1ENSMUSG00000031162Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gata1b / GATA binding protein 1b / GATA1* / P17679* / P15976* / GATA binding protein 1* / Erythroid transcription factor *ENSDARG0000005913044
gata2a / GATA binding protein 2a / GATA2* / O09100* / P23769* / GATA binding protein 2* / Mus musculus GATA binding protein 2 (Gata2), transcript variant 2, mRNA.*ENSDARG0000005932743
gata3 / Q91428 / GATA binding protein 3 / P23771* / P23772* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*ENSDARG0000001652641
gata2b / GATA binding protein 2bENSDARG0000000909437
gata6 / GATA binding protein 6 / Q61169* / Q92908* / Transcription factor GATA-6 *ENSDARG0000010358932
gata5 / GATA binding protein 5 / P97489* / Q9BWX5* / Transcription factor GATA-5 *ENSDARG0000001782129
gata4 / GATA binding protein 4 / P43694* / Q08369* / Transcription factor GATA-4 *ENSDARG0000009895227
trps1 / trichorhinophalangeal syndrome I / Q9UHF7* / transcriptional repressor GATA binding 1*ENSDARG0000010408220


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR013088  Zinc finger, NHR/GATA-type
 IPR016374  Transcription factor, GATA-2/3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0030099 myeloid cell differentiation IGI
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0030223 neutrophil differentiation IMP
 biological_processGO:0030224 monocyte differentiation IMP
 biological_processGO:0030225 macrophage differentiation IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045637 regulation of myeloid cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0060215 primitive hemopoiesis IMP
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005667 transcription factor complex IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood decreased viscosity , abnormal
blood circulating cell absent , abnormal
blood decreased amount , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle increased amount , abnormal
Show

 ZFA:0000014 dorsal aorta dorsal aorta decreased amount , abnormal
dorsal aorta amount , ameliorated
dorsal aorta anatomical region absent , abnormal
dorsal aorta vascular associated smooth muscle cell absent , abnormal
dorsal aorta vascular associated smooth muscle cell decreased amount , abnormal
Show

 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm mislocalised , abnormal
intermediate cell mass of mesoderm position , ameliorated
Show

 ZFA:0000037 anatomical structure anatomical structure decreased amount , abnormal
anatomical structure amount , ameliorated
Show

 ZFA:0000094 blood island blood island hematopoietic multipotent progenitor cell absent , abnormal
blood island mislocalised , abnormal
blood island position , ameliorated
Show

 ZFA:0000173 bulbus arteriosus bulbus arteriosus absent , abnormal
Show

 ZFA:0000186 common cardinal vein common cardinal vein blood vessel endothelial cell decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , abnormal
Show

 ZFA:0001315 atrioventricular canal atrioventricular canal increased amount , abnormal
atrioventricular canal decreased amount , abnormal
atrioventricular canal blood circulation process quality , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001614 atrial endocardium atrial endocardium endothelial cell increased amount , abnormal
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 ZFA:0005000 basal communicating artery basal communicating artery attached to primordial midbrain channel , abnormal
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 ZFA:0005002 basilar artery basilar artery attached to primordial hindbrain channel , abnormal
Show

 ZFA:0005064 atrioventricular valve atrioventricular valve morphology , abnormal
atrioventricular valve absent , abnormal
Show

 ZFA:0009015 erythroid progenitor cell erythroid progenitor cell absent , abnormal
Show

 ZFA:0009065 endothelial cell endothelial cell decreased amount , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
nucleate erythrocyte absent , abnormal
nucleate erythrocyte present , abnormal
nucleate erythrocyte shape , abnormal
nucleate erythrocyte increased size , abnormal
Show

 ZFA:0009324 myeloid cell myeloid cell increased amount , abnormal
Show

 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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