ENSMUSG00000049577


Mus musculus

Features
Gene ID: ENSMUSG00000049577
  
Biological name :Zfpm1
  
Synonyms : O35615 / Zfpm1 / zinc finger protein, multitype 1
  
Possible biological names infered from orthology : Q8IX07 / zinc finger protein, FOG family member 1
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 122282141
Gene end: 122337251
  
Corresponding Affymetrix probe sets: 10576090 (MoGene1.0st)   1423603_at (Mouse Genome 430 2.0 Array)   1451046_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058037
NCBI entrez gene - 22761     See in Manteia.
MGI - MGI:1095400
RefSeq - NM_009569
RefSeq - XM_006530851
RefSeq Peptide - NP_033595
swissprot - O35615
Ensembl - ENSMUSG00000049577
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zfpm1ENSDARG00000041572Danio rerio
 ZFPM1ENSGALG00000006099Gallus gallus
 ZFPM1ENSG00000179588Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zfpm2 / Q8CCH7 / zinc finger protein, multitype 2 / Q8WW38* / zinc finger protein, FOG family member 2*ENSMUSG0000002230632


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR034731  Zinc finger CCHC FOG-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003181 atrioventricular valve morphogenesis IMP
 biological_processGO:0003192 mitral valve formation IMP
 biological_processGO:0003195 tricuspid valve formation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0010724 regulation of definitive erythrocyte differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0030219 megakaryocyte differentiation IMP
 biological_processGO:0030220 platelet formation IEA
 biological_processGO:0030851 granulocyte differentiation IMP
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0032642 regulation of chemokine production IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0035855 megakaryocyte development IMP
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process IEA
 biological_processGO:0045403 negative regulation of interleukin-4 biosynthetic process IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0055008 cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060318 definitive erythrocyte differentiation IMP
 biological_processGO:0060319 primitive erythrocyte differentiation IMP
 biological_processGO:0060377 negative regulation of mast cell differentiation IDA
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060413 atrial septum morphogenesis IMP
 biological_processGO:0071733 transcriptional activation by promoter-enhancer looping IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

Allelic Composition: Zfpm1tm1Sho/Zfpm1tm1Sho
Genetic Background: involves: 129S1/Sv

Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Zfpm1tm4Sho/Zfpm1tm4Sho,Tg(Gata1-Zfpm1)1Sho/0,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: En1tm1Alj/En1tm8.1Alj,En2tm1Alj/En2tm6Alj,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Swiss Webster

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prdx1tm1Rave/Prdx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfpm1tm1Sho/Zfpm1tm1Sho
Genetic Background: involves: 129S1/Sv

Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Csf2tm1Dran/Csf2tm1Dran,Ifngtm1Ts/Ifngtm1Ts,Il3tm1Glli/Il3tm1Glli
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Zfpm1tm4Sho/Zfpm1tm4Sho,Tg(Gata1-Zfpm1)1Sho/0,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

Allelic Composition: Zfpm1tm1.1Geab/Zfpm1+
Genetic Background: Not Specified

Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

Allelic Composition: Tg(Gata1-Zfpm1)1Sho/0,Zfpm1tm1Sho/Zfpm1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6N * CD-1

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0008850 increased hemoglobin concentration distribution width "higher than normal standard deviation of the distribution of erythrocytes by their cellular (individual) hemoglobin concentrations; high HDW is indicative of some types of anemia/thalassemia" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

Allelic Composition: Zfpm1tm1.1Geab/Zfpm1+
Genetic Background: Not Specified

Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Tg(Gata1-Zfpm1)1Sho/0,Zfpm1tm1Sho/Zfpm1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6N * CD-1

Allelic Composition: Zfpm1tm4Sho/Zfpm1tm4Sho,Tg(Gata1-Zfpm1)1Sho/0,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Tg(Gata1-Zfpm1)1Sho/0,Zfpm1tm1Sho/Zfpm1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6N * CD-1

Allelic Composition: Zfpm1tm4Sho/Zfpm1tm4Sho,Tg(Gata1-Zfpm1)1Sho/0,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Tg(Gata1-Zfpm1)1Sho/0,Zfpm1tm1Sho/Zfpm1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6N * CD-1

Allelic Composition: Zfpm1tm4Sho/Zfpm1tm4Sho,Tg(Gata1-Zfpm1)1Sho/0,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0010607 common atrioventricular valve "the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Gata1-Zfpm1)1Sho/0,Zfpm1tm1Sho/Zfpm1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6N * CD-1

Allelic Composition: Zfpm1tm4Sho/Zfpm1tm4Sho,Tg(Gata1-Zfpm1)1Sho/0,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Zfpm1tm2Sho/Zfpm1tm2Sho
Genetic Background: either: (involves: 129S1/Sv) or (involves: 129S1/Sv * C57BL/6)

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tg(Gata1-Zfpm1)1Sho/0,Zfpm1tm1Sho/Zfpm1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6N * CD-1

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Zfpm1tm1.1Esv/Zfpm1tm1.1Esv
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

 MP:0020431 decreased platelet alpha-granule number "decreased number of platelet alpha-granules" []
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Allelic Composition: Zfpm1tm1.1Geab/Zfpm1tm1.1Geab
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031162 Gata1 / P17679 / Erythroid transcription factor / P15976* / GATA binding protein 1*  / complex






 

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