Manteia - Molecule gene

ENSMUSG00000022306

Mus musculus

Features

Gene ID:	ENSMUSG00000022306

Biological name :	Zfpm2

Synonyms :	Q8CCH7 / Zfpm2 / zinc finger protein, multitype 2

Possible biological names infered from orthology :	Q8WW38 / zinc finger protein, FOG family member 2

Species:	Mus musculus

Chr. number:	15
Strand:	1
Band:	B3.1
Gene start:	40655035
Gene end:	41104592

Corresponding Affymetrix probe sets:	10423902 (MoGene1.0st) 1419012_at (Mouse Genome 430 2.0 Array) 1449314_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000155094 Ensembl peptide - ENSMUSP00000051335 NCBI entrez gene - 22762 See in Manteia. MGI - MGI:1334444 RefSeq - NM_011766 RefSeq - XM_006520897 RefSeq Peptide - NP_035896 swissprot - A5HE91 swissprot - Q8CCH7 Ensembl - ENSMUSG00000022306

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
zfpm2a	ENSDARG00000040123	Danio rerio
ZFPM2	ENSGALG00000040079	Gallus gallus
ZFPM2	ENSG00000169946	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Zfpm1 / O35615 / zinc finger protein, multitype 1 / Q8IX07* / zinc finger protein, FOG family member 1*	ENSMUSG00000049577	27

Protein motifs (from Interpro)

Interpro ID	Name
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR013087	Zinc finger C2H2-type
IPR034731	Zinc finger CCHC FOG-type
IPR036236	Zinc finger C2H2 superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0001570	vasculogenesis	IMP
biological_process	GO:0001701	in utero embryonic development	IMP
biological_process	GO:0003148	outflow tract septum morphogenesis	IEA
biological_process	GO:0003151	outflow tract morphogenesis	TAS
biological_process	GO:0003181	atrioventricular valve morphogenesis	TAS
biological_process	GO:0003192	mitral valve formation	TAS
biological_process	GO:0003195	tricuspid valve formation	TAS
biological_process	GO:0003221	right ventricular cardiac muscle tissue morphogenesis	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007507	heart development	IMP
biological_process	GO:0030324	lung development	IMP
biological_process	GO:0045599	negative regulation of fat cell differentiation	IEA
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	TAS
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	TAS
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0048568	embryonic organ development	ISO
biological_process	GO:0048738	cardiac muscle tissue development	IMP
biological_process	GO:0055008	cardiac muscle tissue morphogenesis	TAS
biological_process	GO:0060045	positive regulation of cardiac muscle cell proliferation	IGI
biological_process	GO:0060412	ventricular septum morphogenesis	IEA
biological_process	GO:0060548	negative regulation of cell death	IMP
biological_process	GO:0060979	vasculogenesis involved in coronary vascular morphogenesis	TAS
biological_process	GO:2000020	positive regulation of male gonad development	IMP
biological_process	GO:2000195	negative regulation of female gonad development	IMP
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005737	cytoplasm	IDA
molecular_function	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IBA
molecular_function	GO:0001085	RNA polymerase II transcription factor binding	IBA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003714	transcription corepressor activity	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008134	transcription factor binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Factors involved in megakaryocyte development and platelet production

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Maoa^{Tg(H2-K1-Ifnb1)8Seif}/? Genetic Background: involves: C3H/HeJ
MP:0000273	overriding aorta	"congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0000277	abnormal heart shape	"malformation of the form or the patterning of the heart" [J:18048]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac
MP:0000280	thin ventricular wall	"decreased depth of the cardiac wall of the heart ventricles" [J:45302]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J
MP:0000285	abnormal cardiac valve morphology	"malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]	Show Allelic Composition: Maoa^{Tg(H2-K1-Ifnb1)8Seif}/? Genetic Background: involves: C3H/HeJ
MP:0000297	abnormal endocardial cushion morphology	"malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Wt1^{tm1(EGFP/cre)Wtp}/Wt1⁺,Zfpm2^tm1Sho/Zfpm2^tm2Sho Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd
MP:0000601	small liver	"reduced size of the liver" [J:23170]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac
MP:0000627	abnormal mammary gland morphology	"malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]	Show Allelic Composition: Notch1^tm3(cre)Rko/Notch1^tm3(cre)Rko Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL
MP:0000761	thin diaphragm muscle	"reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]	Show Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Pou2f3^tm1Rsd/Pou2f3^tm1Rsd,Pou3f1^tm1Rsd/Pou3f1^tm1Rsd Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J
MP:0001176	abnormal lung development	"malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac
MP:0001178	pulmonary hypoplasia	"reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J
MP:0001786	skin edema	"accumulation of an excessive amount of fluid in the skin" [J:65039]	Show Allelic Composition: Maoa^{Tg(H2-K1-Ifnb1)8Seif}/? Genetic Background: involves: C3H/HeJ Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0001787	pericardial edema	"accumulation of watery fluid in the pericardial sac of the heart" [J:52597]	Show Allelic Composition: Maoa^{Tg(H2-K1-Ifnb1)8Seif}/? Genetic Background: involves: C3H/HeJ
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Notch1^tm3(cre)Rko/Notch1^tm3(cre)Rko Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL Allelic Composition: Zfpm2^tm1.1Wtp/Zfpm2^tm1.1Wtp Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster
MP:0002192	hydrops fetalis	"an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac
MP:0002211	abnormal primary sex determination	"aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pou2f3^tm1Rsd/Pou2f3^tm1Rsd,Pou3f1^tm1Rsd/Pou3f1^tm1Rsd Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J
MP:0002279	abnormal diaphragm morphology	"structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J
MP:0002652	thin myocardial wall	"thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J
MP:0002747	abnormal aortic valve morphology	"malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Maoa^{Tg(H2-K1-Ifnb1)8Seif}/? Genetic Background: involves: C3H/HeJ
MP:0002748	abnormal pulmonary valve morphology	"malformation of the valve between the right ventricle and the pulmonary trunk" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Maoa^{Tg(H2-K1-Ifnb1)8Seif}/? Genetic Background: involves: C3H/HeJ
MP:0002784	abnormal Sertoli cell morphology	"malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pou2f3^tm1Rsd/Pou2f3^tm1Rsd,Pou3f1^tm1Rsd/Pou3f1^tm1Rsd Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J
MP:0002925	abnormal cardiovascular development	"aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Tg(Tnnt2-rtTA,tetO-cre)1Wtp/0 Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0002995	primary sex reversal	"gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Pou2f3^tm1Rsd/Pou2f3^tm1Rsd,Pou3f1^tm1Rsd/Pou3f1^tm1Rsd Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6J
MP:0003105	abnormal heart atrium morphology	"structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Zfpm2^tm1Jml/Zfpm2^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0003140	dilated atria	"an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Zfpm2^tm1Jml/Zfpm2^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0003222	increased cardiomyocyte apoptosis	"increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Tg(Tnnt2-rtTA,tetO-cre)1Wtp/0 Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac
MP:0003808	enlarged endocardial cushions	"larger than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [mac:Megan A. Cassell, Mouse Genome Informatics Curator]	Show Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J
MP:0003920	abnormal right ventricle morphology	"structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Zfpm2^tm1Jml/Zfpm2^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0004056	abnormal myocardial compact layer morphology	"malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Cep290^{Gt(CC0582)Wtsi}/Cep290^{Gt(CC0582)Wtsi} Genetic Background: 129P2/OlaHsd-Cep290^{Gt(CC0582)Wtsi}
MP:0004057	thin myocardial compact layer	"reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Wt1^{tm1(EGFP/cre)Wtp}/Wt1⁺,Zfpm2^tm1Sho/Zfpm2^tm2Sho Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd Allelic Composition: Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0004215	abnormal myocardial fiber physiology	"anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gata4^tm1Sho/Gata4^tm1.1Wtp,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0004937	dilated heart	"stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Tg(Tnnt2-rtTA,tetO-cre)1Wtp/0 Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0005294	abnormal heart ventricle morphology	"structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Maoa^{Tg(H2-K1-Ifnb1)8Seif}/? Genetic Background: involves: C3H/HeJ
MP:0005312	pericardial effusion	"escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac
MP:0005598	decreased ventricle muscle contractility	"reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0006111	abnormal coronary circulation	"anomalous circulation of blood through the vessels that supply the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0006123	tricuspid valve atresia	"congenital closure of the tricuspid valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Zfpm2^tm1Jml/Zfpm2^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0006138	congestive heart failure	"the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Zfpm2^tm1Jml/Zfpm2^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0006271	abnormal involution of the mammary gland	"anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Notch1^tm3(cre)Rko/Notch1^tm3(cre)Rko Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL
MP:0008022	dilated heart ventricles	"the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0008725	enlarged heart atrium	"increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]	Show Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J
MP:0008825	abnormal cardiac epithelial to mesenchymal transition	"anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac
MP:0009573	abnormal right lung middle lobe morphology		Show Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J
MP:0010224	abnormal heart ventricle outflow tract morphology	"any structural anomaly of the superior portion of the ventricles of the heart through which blood flows into the arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Zfpm2^tm1Jml/Zfpm2^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J Allelic Composition: Zfpm2^tm1Jml/Zfpm2^tm1Jml Genetic Background: involves: 129X1/SvJ Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj,Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 Allelic Composition: Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj,Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 Allelic Composition: Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0010404	ostium primum atrial septal defect	"interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J
MP:0010413	complete atrioventricular septal defect	"a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]	Show Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J Allelic Composition: Zfpm2^tm1Jml/Zfpm2^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0010449	heart right ventricle outflow tract stenosis	"abnormal constriction or narrowing of part of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Zfpm2^tm1Jml/Zfpm2^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0010459	supravalvar pulmonary trunk stenosis	"diffuse constriction or narrowing of the pulmonary trunk distal to the pulmonary valve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac
MP:0010551	abnormal coronary vessel morphology	"any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0010556	thin ventricle myocardium compact layer	"reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfpm2^tm1Jml/Zfpm2^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0010561	absent coronary vessels	"absence of the arteries and veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac
MP:0010601	thick pulmonary valve	"an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfpm2^tm1Jml/Zfpm2^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0010607	common atrioventricular valve	"the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm1Sho,Tg(Myh6-Zfpm2)1Sho/0 Genetic Background: involves: 129S1/Sv Allelic Composition: Zfpm2^tm1Jml/Zfpm2^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0010640	ventricular myocardium compact layer hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac
MP:0010824	absent right lung accessory lobe	"absence of the right lung lobe which lies against the diaphragm and has a considerable volume residing in the left hemi-thorax" [ISBN:0486631850 "Green, E Biology Of The Laboratory Mouse", PMID:2050021]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj,Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Wt1^{tm1(EGFP/cre)Wtp}/Wt1⁺,Zfpm2^tm1Sho/Zfpm2^tm2Sho Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Zfpm2^tm1Jml/Zfpm2^tm1Jml Genetic Background: involves: 129X1/SvJ
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Gata4^tm1.1Sho/Gata4^tm1.1Sho Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm1Sho,Tg(Myh6-Zfpm2)1Sho/0 Genetic Background: involves: 129S1/Sv Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm2Sho,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Zfpm2^lil/Zfpm2^lil Genetic Background: involves: A/J
MP:0011925	abnormal heart echocardiography feature	"any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]	Show Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj,Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 Allelic Composition: Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0013602	abnormal Leydig cell differentiation	"atypical formation of or inability to produce the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone; in most mammals, normal Leydig cell (LC) development comprises two sequential but overlapping cell lineages known as the fetal and adult type LC populations, which display distinct functional characteristics reflected by different morphology, hormonal regulation, and steroidogenic output" [http://press.endocrine.org/doi/full/10.1210/en.2012-2273, MGI:Anna]	Show Allelic Composition: Zfpm2^tm1Sho/Zfpm2^tm1Sho,Tg(Myh6-Zfpm2)1Sho/0 Genetic Background: involves: 129S1/Sv
MP:0020135	abnormal heart ventricle wall thickness	"anomaly in the depth of the cardiac wall of the heart ventricles" [GOC:NV]	Show Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj,Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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