ENSMUSG00000021264


Mus musculus

Features
Gene ID: ENSMUSG00000021264
  
Biological name :Yy1
  
Synonyms : Q00899 / Yy1 / YY1 transcription factor
  
Possible biological names infered from orthology : P25490
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 108792973
Gene end: 108820148
  
Corresponding Affymetrix probe sets: 10398288 (MoGene1.0st)   1422569_at (Mouse Genome 430 2.0 Array)   1422570_at (Mouse Genome 430 2.0 Array)   1435824_at (Mouse Genome 430 2.0 Array)   1457834_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021692
NCBI entrez gene - 22632     See in Manteia.
MGI - MGI:99150
RefSeq - NM_009537
RefSeq Peptide - NP_033563
swissprot - Q00899
Ensembl - ENSMUSG00000021264
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 yy1aENSDARG00000042796Danio rerio
 yy1bENSDARG00000027978Danio rerio
 YY2ENSGALG00000017388Gallus gallus
 YY1ENSG00000100811Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Yy2 / Q3TTC2 / Yy2 transcription factor / O15391*ENSMUSG0000009173654
Zfp42 / zinc finger protein 42 / Q96MM3* / ZFP42 zinc finger protein*ENSMUSG0000005117626
O70230 / Zfp143 / zinc finger protein 143 / P52747* / ZNF143*ENSMUSG0000006107918
Mtf1 / Q07243 / Metal regulatory transcription factor 1 / Q14872*ENSMUSG0000002889016
Zxdb / A2CE44 / zinc finger, X-linked, duplicated B / ZXDA* / P98169* / P98168* / zinc finger, X-linked, duplicated A*ENSMUSG0000007306216
Q8BMU0 / Zfp523 / zinc finger protein 523 / ZNF76* / P36508* / zinc finger protein 76*ENSMUSG0000002422016
Gtf3a / transcription factor IIIA / Q92664* / general transcription factor IIIA*ENSMUSG0000001650314
Zxdc / Q8C8V1 / ZXD family zinc finger C / Q2QGD7*ENSMUSG0000003443014
Q8BKX7 / Zfp410 / zinc finger protein 410 / Q86VK4* / ZNF410*ENSMUSG0000004247214


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR017114  C2H2-type Zinc finger protein, YY-1-like
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006403 RNA localization IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010225 response to UV-C IMP
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032688 negative regulation of interferon-beta production IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0034696 response to prostaglandin F IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048593 camera-type eye morphogenesis IGI
 biological_processGO:0051276 chromosome organization IMP
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II IDA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0031011 Ino80 complex IEA
 cellular_componentGO:0031519 PcG protein complex IDA
 molecular_functionGO:0000400 four-way junction DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
UCH proteinases
DNA Damage Recognition in GG-NER
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Braftm1Tumg/Braf+,Tg(CAG-cre)2Osb/0
Genetic Background: involves: C57BL * C57BL/6J * DBA

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0001694 failure to form egg cylinders "inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure" [The Atlas of Mouse Development , Revised edition:ISBN 0-12-402035-6, MGI:cls, J:34458]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0002282 abnormal trachea morphology "structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002285 abnormal tracheal ciliated epithelium morphology "structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0004880 lung cysts 
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008021 blastoma "a fast growing and invasive tumor composed chiefly or entirely of immature undifferentiated cells that have embryonic characteristics resembling the primordium of the organ in which the tumor arose" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0010862 decreased respiratory mucosa goblet cell number "reduced number of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010883 trachea stenosis "abnormal narrowing or constriction of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010949 decreased Clara cell number "reduced number of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011024 abnormal branching involved in lung morphogenesis "anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0011113 abnormal airway basal cell morphology "any structural anomaly of a long-lived multipotent stem cell of the pseudostratified airway epithelium which is restricted to the tracheal epithelium in mice; airway BCs have been shown to be capable of self renewal, give rise to secretory (Clara) cells and ciliated cells, and play important roles both in epithelial homeostasis and in pathological airway remodeling" [MGI:anna, PMID:20699479]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011142 abnormal lung-associated mesenchyme development "abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung" [MGI:anna, PMID:18533146, PMID:20048339]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012197 impaired myofibroblast differentiation 
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0014200 abnormal respiratory epithelium physiology "any functional anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi" [ISBN:0-683-40008-8, MGI:Anna]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0030002 increased lung apoptosis "acceleration in the timing or in the number of cells of the lung undergoing programmed cell death" [ORCID:orcid.org/0000-0002-6490-7723, PMID:17589521]
Show

Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021901 Bap1 / Q99PU7 / Ubiquitin carboxyl-terminal hydrolase BAP1 / Q92560* / BRCA1 associated protein 1*  / reaction / complex
 ENSMUSG00000031386 Hcfc1 / Q61191 / Host cell factor 1 HCF N-terminal chain 1 HCF N-terminal chain 2 HCF N-terminal chain 3 HCF N-terminal chain 4 HCF N-terminal chain 5 HCF N-terminal chain 6 HCF C-terminal c...  / complex
 ENSMUSG00000035451 Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*  / reaction
 ENSMUSG00000034160 Ogt / Q8CGY8 / UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit / O15294* / O-linked N-acetylglucosamine (GlcNAc) transferase*  / complex
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / complex
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex
 ENSMUSG00000056493 Foxk1 / P42128 / Forkhead box protein K1 / P85037* / forkhead box K1*  / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex
 ENSMUSG00000039275 Foxk2 / Q3UCQ1 / Forkhead box protein K2 / Q01167* / forkhead box K2*  / complex
 ENSMUSG00000015619 Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*  / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / complex
 ENSMUSG00000042548 Asxl1 / P59598 / Putative Polycomb group protein ASXL1 / Q8IXJ9* / additional sex combs like 1, transcriptional regulator*  / complex






 

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