Manteia - Molecule gene

ENSMUSG00000042548

Mus musculus

Features

Gene ID:	ENSMUSG00000042548

Biological name :	Asxl1

Synonyms :	Asxl1 / P59598 / Putative Polycomb group protein ASXL1

Possible biological names infered from orthology :	additional sex combs like 1, transcriptional regulator / Q8IXJ9

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	H1
Gene start:	153345829
Gene end:	153404007

Corresponding Affymetrix probe sets:	10477311 (MoGene1.0st) 1434561_at (Mouse Genome 430 2.0 Array) 1435077_at (Mouse Genome 430 2.0 Array) 1458380_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000105413 Ensembl peptide - ENSMUSP00000154224 NCBI entrez gene - 228790 See in Manteia. MGI - MGI:2684063 RefSeq - XM_006499330 RefSeq - NM_001039939 RefSeq Peptide - NP_001035028 swissprot - P59598 swissprot - Q24JP2 Ensembl - ENSMUSG00000042548

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
asxl1	ENSDARG00000036956	Danio rerio
ASXL1	ENSGALG00000006612	Gallus gallus
ASXL1	ENSG00000171456	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Asxl2 / putative Polycomb group protein ASXL2 isoform 1 / Q76L83* / additional sex combs like 2, transcriptional regulator*	ENSMUSG00000037486	26
Asxl3 / Q8C4A5 / Putative Polycomb group protein ASXL3 / Q9C0F0* / additional sex combs like 3, transcriptional regulator*	ENSMUSG00000045215	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR007759	HB1/Asxl, restriction endonuclease HTH domain
IPR024811	Polycomb protein ASX/ASX-like
IPR024815	ASX-like protein 1
IPR026905	Protein ASX-like, PHD domain
IPR028020	ASX homology domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000902	cell morphogenesis	IMP
biological_process	GO:0003007	heart morphogenesis	IMP
biological_process	GO:0006325	chromatin organization	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0009887	animal organ morphogenesis	IMP
biological_process	GO:0030097	hemopoiesis	IMP
biological_process	GO:0032526	response to retinoic acid	IDA
biological_process	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	IDA
biological_process	GO:0035522	monoubiquitinated histone H2A deubiquitination	IEA
biological_process	GO:0045599	negative regulation of fat cell differentiation	IDA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0048386	positive regulation of retinoic acid receptor signaling pathway	IDA
biological_process	GO:0048534	hematopoietic or lymphoid organ development	IMP
biological_process	GO:0048538	thymus development	IMP
biological_process	GO:0048539	bone marrow development	IMP
biological_process	GO:0048872	homeostasis of number of cells	IMP
biological_process	GO:0060348	bone development	IMP
biological_process	GO:0060430	lung saccule development	IMP
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0035517	PR-DUB complex	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003713	transcription coactivator activity	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0042974	retinoic acid receptor binding	IDA
molecular_function	GO:0042975	peroxisome proliferator activated receptor binding	IDA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

UCH proteinases

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0000220	increased monocyte count	"greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: B6Dnk;B6Brd;B6N-Asxl1^{tm1a(EUCOMM)Wtsi} Tyr^c-Brd/WtsiH
MP:0000222	decreased neutrophil count	"fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0000223	decreased monocyte count	"fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA
MP:0000321	increased bone marrow cell number	"increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0000351	increased cell proliferation	"greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0000428	abnormal craniofacial morphology	"anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000460	mandible hypoplasia	"arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]	Show Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0000693	spleen hyperplasia	"increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6
MP:0000716	abnormal immune system cell morphology	"anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tet2^tm1.1Iaai/Tet2^tm1.1Iaai,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA
MP:0001293	anophthalmia	"congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]	Show Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ap4e1^{tm1a(KOMP)Wtsi}/Ap4e1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1a(KOMP)Wtsi}/Wtsi
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ap4e1^{tm1a(KOMP)Wtsi}/Ap4e1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1a(KOMP)Wtsi}/Wtsi
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0001601	abnormal myelopoiesis	"atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tet2^tm1.1Iaai/Tet2^tm1.1Iaai,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0001606	impaired hematopoiesis	"atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0002018	malignant tumors	"higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0002026	leukemia	"progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0002032	sarcoma	"connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0002123	abnormal hematopoiesis	"abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0002357	abnormal spleen white pulp morphology	"anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0002398	abnormal bone marrow cell morphology/development	"anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0002401	abnormal lymphopoiesis	"atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6
MP:0002417	abnormal megakaryocyte morphology/development	"anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0002429	abnormal blood cell morphology/development	"anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0002463	abnormal neutrophil physiology	"abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Acp2^{tm1a(EUCOMM)Wtsi}/Acp2^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Acp2^{tm1a(EUCOMM)Wtsi}/H
MP:0002700	opacity of vitreous body	"milky or cloudy eyeball that is impervious to light" [J:30249]	Show Allelic Composition: Braf^tm1Mmcm/Braf^tm1Mmcm,Nkx3-1^{tm4(cre/ERT2)Mms}/Nkx3-1⁺,Pten^tm1Hwu/Pten⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0002702	decreased circulating free fatty acid level	"lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: C57BL/6N-Asxl1^{tm1a(EUCOMM)Wtsi}/Cnrm
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: B6Dnk;B6Brd;B6N-Asxl1^{tm1a(EUCOMM)Wtsi} Tyr^c-Brd/WtsiH
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: C57BL/6N-Asxl1^{tm1a(EUCOMM)Wtsi}/Cnrm
MP:0003036	vertebral transformation	"homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003056	abnormal hyoid bone	"anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003062	abnormal coping response	"altered ability to respond productively to a stressful situation or stimulus, or failure to seek pleasurable stimuli" [RGD:Rat Genome Database submission]	Show Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: C57BL/6N-Asxl1^{tm1a(EUCOMM)Wtsi}/Cnrm
MP:0003135	increased erythrocyte precursors	"greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0003643	spleen atrophy	"wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0004609	vertebral fusion	"the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: B6Dnk;B6Brd;B6N-Asxl1^{tm1a(EUCOMM)Wtsi} Tyr^c-Brd/WtsiH
MP:0004647	decreased lumbar vertebrae number	"reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: B6Dnk;B6Brd;B6N-Asxl1^{tm1a(EUCOMM)Wtsi} Tyr^c-Brd/WtsiH
MP:0004808	abnormal hematopoietic stem cell morphology	"any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0004809	increased hematopoietic stem cell number	"greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0004810	decreased hematopoietic stem cell number	"reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: C57BL/6N-Asxl1^{tm1a(EUCOMM)Wtsi}/Cnrm
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6
MP:0005065	abnormal neutrophil morphology	"structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6
MP:0005097	polychromatophilia	"condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: B6Dnk;B6Brd;B6N-Asxl1^{tm1a(EUCOMM)Wtsi} Tyr^c-Brd/WtsiH
MP:0005562	decreased mean corpuscular hemoglobin	"less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: B6Dnk;B6Brd;B6N-Asxl1^{tm1a(EUCOMM)Wtsi} Tyr^c-Brd/WtsiH
MP:0005641	increased mean corpuscular hemoglobin concentration	"greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]	Show Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: C57BL/6N-Asxl1^{tm1a(EUCOMM)Wtsi}/Cnrm
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0006410	abnormal common myeloid progenitor cell morphology	"anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6
MP:0008082	increased single-positive T cell number	"greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0008209	decreased pre-B cell number	"reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Rbpj^tm1Hon/Rbpj^tm1Hon,Tg(tetO-cre)1Jaw/0 Genetic Background: involves: 129 * C57BL/6
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0008246	abnormal leukocyte morphology	"any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1⁺ Genetic Background: involves: 129 * C57BL/6
MP:0008477	decreased spleen red pulp amount	"reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0008810	increased circulating iron level	"elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: C57BL/6N-Asxl1^{tm1a(EUCOMM)Wtsi}/Cnrm
MP:0008821	increased blood uric acid level	"greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: B6Dnk;B6Brd;B6N-Asxl1^{tm1a(EUCOMM)Wtsi} Tyr^c-Brd/WtsiH
MP:0008973	decreased erythroid progenitor cell number	"reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0009339	decreased splenocyte number	"reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0009395	persistence of primitive erythrocytes	"presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA Allelic Composition: Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S/SvEv * C57BL/6
MP:0009859	eye opacity	"changes in the eye grossly observed as a milky or cloudy appearance that may be progressive and persistent throughout life" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Braf^tm1Mmcm/Braf^tm1Mmcm,Nkx3-1^{tm4(cre/ERT2)Mms}/Nkx3-1⁺,Pten^tm1Hwu/Pten⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0010101	increased sacral vertebrae number	"increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: B6Dnk;B6Brd;B6N-Asxl1^{tm1a(EUCOMM)Wtsi} Tyr^c-Brd/WtsiH
MP:0010178	increased number of Howell-Jolly bodies	"abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0010373	myeloid hyperplasia	"greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0010763	abnormal hematopoietic stem cell physiology	"any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Tbx21^{tm1.1(flpe/ERT2)Gmld}/Tbx21^{tm1.1(flpe/ERT2)Gmld} Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Asxl1^tm1.1Mjxu/Asxl1^tm1.1Mjxu Genetic Background: involves: 129 * C57BL/6
MP:0011400	complete lethality	"all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]	Show Allelic Composition: Braf^tm1Mmcm/Braf^tm1Mmcm,Nkx3-1^{tm4(cre/ERT2)Mms}/Nkx3-1⁺,Pten^tm1Hwu/Pten⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000021901	Bap1 / Q99PU7 / Ubiquitin carboxyl-terminal hydrolase BAP1 / Q92560* / BRCA1 associated protein 1*	/ reaction / complex
ENSMUSG00000034160	Ogt / Q8CGY8 / UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit / O15294* / O-linked N-acetylglucosamine (GlcNAc) transferase*	/ complex
ENSMUSG00000021264	Yy1 / Q00899 / YY1 transcription factor / P25490*	/ complex
ENSMUSG00000056493	Foxk1 / P42128 / Forkhead box protein K1 / P85037* / forkhead box K1*	/ complex
ENSMUSG00000031386	Hcfc1 / Q61191 / Host cell factor 1 HCF N-terminal chain 1 HCF N-terminal chain 2 HCF N-terminal chain 3 HCF N-terminal chain 4 HCF N-terminal chain 5 HCF N-terminal chain 6 HCF C-terminal c...	/ complex
ENSMUSG00000039275	Foxk2 / Q3UCQ1 / Forkhead box protein K2 / Q01167* / forkhead box K2*	/ complex

1 s.

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