ENSMUSG00000031386


Mus musculus

Features
Gene ID: ENSMUSG00000031386
  
Biological name :Hcfc1
  
Synonyms : Hcfc1 / Host cell factor 1 HCF N-terminal chain 1 HCF N-terminal chain 2 HCF N-terminal chain 3 HCF N-terminal chain 4 HCF N-terminal chain 5 HCF N-terminal chain 6 HCF C-terminal chain 1 HCF C-terminal chain 2 HCF C-terminal chain 3 HCF C-terminal chain 4 HCF C-terminal chain 5 HCF C-terminal chain 6 / Q61191
  
Possible biological names infered from orthology : host cell factor C1 / P51610
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A7.3
Gene start: 73942792
Gene end: 73966357
  
Corresponding Affymetrix probe sets: 10605195 (MoGene1.0st)   1421972_s_at (Mouse Genome 430 2.0 Array)   1433736_at (Mouse Genome 430 2.0 Array)   1450439_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115792
Ensembl peptide - ENSMUSP00000033761
Ensembl peptide - ENSMUSP00000110012
NCBI entrez gene - 15161     See in Manteia.
MGI - MGI:105942
RefSeq - XM_006527835
RefSeq - XM_006527836
RefSeq - XM_017318387
RefSeq - NM_008224
RefSeq Peptide - NP_032250
swissprot - Q61191
swissprot - B1AUX2
swissprot - F6SJS2
Ensembl - ENSMUSG00000031386
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hcfc1aENSDARG00000015990Danio rerio
 hcfc1bENSDARG00000012519Danio rerio
 HCFC1ENSG00000172534Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hcfc2 / host cell factor C2 / Q9Y5Z7*ENSMUSG0000002024620
Lztr1 / Q9CQ33 / Mus musculus leucine-zipper-like transcriptional regulator, 1 (Lztr1), transcript variant 2, mRNA. / Q8N653* / leucine zipper like transcription regulator 1*ENSMUSG000000227616
Klhdc3 / kelch domain containing 3 / Q9BQ90*ENSMUSG000000635765
Klhdc2 / Q4G5Y1 / Kelch domain-containing protein 2 / Q9Y2U9* / kelch domain containing 2*ENSMUSG000000209785
Q6PAR0 / Klhdc10 / Kelch domain-containing protein 10 / Q6PID8* / kelch domain containing 10*ENSMUSG000000297754
Klhdc1 / Q80YG3 / Kelch domain-containing protein 1 / Q8N7A1* / kelch domain containing 1*ENSMUSG000000518904
Q8VCH5 / Rabepk / Rab9 effector protein with kelch motifs / Q7Z6M1*ENSMUSG000000709534


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR006652  Kelch repeat type 1
 IPR013783  Immunoglobulin-like fold
 IPR015915  Kelch-type beta propeller
 IPR036116  Fibronectin type III superfamily
 IPR037293  Galactose oxidase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0019046 release from viral latency IDA
 biological_processGO:0043254 regulation of protein complex assembly IEA
 biological_processGO:0043981 histone H4-K5 acetylation IEA
 biological_processGO:0043982 histone H4-K8 acetylation IEA
 biological_processGO:0043984 histone H4-K16 acetylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0000123 histone acetyltransferase complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0048188 Set1C/COMPASS complex IEA
 cellular_componentGO:0070461 SAGA-type complex IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043995 histone acetyltransferase activity (H4-K5 specific) IEA
 molecular_functionGO:0043996 histone acetyltransferase activity (H4-K8 specific) IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046972 histone acetyltransferase activity (H4-K16 specific) IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones
UCH proteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cul3tm1Suc/Cul3+
Genetic Background: involves: C57BL/6

Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hcfc1tm1Lwh/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cul3tm1Suc/Cul3+
Genetic Background: involves: C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Hcfc1tm1Lwh/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Hcfc1tm1Lwh/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0014134 abnormal embryo morphology "any structural anomaly of an embryo " [MGI:csmith]
Show

Allelic Composition: Hcfc1tm1Lwh/Hcfc1+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021901 Bap1 / Q99PU7 / Ubiquitin carboxyl-terminal hydrolase BAP1 / Q92560* / BRCA1 associated protein 1*  / complex / reaction
 ENSMUSG00000056493 Foxk1 / P42128 / Forkhead box protein K1 / P85037* / forkhead box K1*  / complex
 ENSMUSG00000021264 Yy1 / Q00899 / YY1 transcription factor / P25490*  / complex
 ENSMUSG00000039275 Foxk2 / Q3UCQ1 / Forkhead box protein K2 / Q01167* / forkhead box K2*  / complex
 ENSMUSG00000034160 Ogt / Q8CGY8 / UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit / O15294* / O-linked N-acetylglucosamine (GlcNAc) transferase*  / complex
 ENSMUSG00000042548 Asxl1 / P59598 / Putative Polycomb group protein ASXL1 / Q8IXJ9* / additional sex combs like 1, transcriptional regulator*  / complex






 

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