ENSMUSG00000034160


Mus musculus

Features
Gene ID: ENSMUSG00000034160
  
Biological name :Ogt
  
Synonyms : Ogt / Q8CGY8 / UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
  
Possible biological names infered from orthology : O15294 / O-linked N-acetylglucosamine (GlcNAc) transferase
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: D
Gene start: 101640060
Gene end: 101684351
  
Corresponding Affymetrix probe sets: 10601235 (MoGene1.0st)   1425516_at (Mouse Genome 430 2.0 Array)   1425517_s_at (Mouse Genome 430 2.0 Array)   1436780_at (Mouse Genome 430 2.0 Array)   1451738_at (Mouse Genome 430 2.0 Array)   1460631_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045409
Ensembl peptide - ENSMUSP00000113454
NCBI entrez gene - 108155     See in Manteia.
MGI - MGI:1339639
RefSeq - XM_011247503
RefSeq - NM_001290535
RefSeq - NM_139144
RefSeq - XM_006527736
RefSeq Peptide - NP_001277464
RefSeq Peptide - NP_631883
swissprot - Q8CGY8
Ensembl - ENSMUSG00000034160
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ogt.1ENSDARG00000105243Danio rerio
 ogt.1ENSDARG00000099455Danio rerio
 OGTENSGALG00000005425Gallus gallus
 OGTENSG00000147162Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tmtc1 / Q3UV71 / Mus musculus transmembrane and tetratricopeptide repeat containing 1 (Tmtc1), transcript variant 2, mRNA. / Q8IUR5* / transmembrane and tetratricopeptide repeat containing 1*ENSMUSG0000003030613
Tmtc3 / transmembrane and tetratricopeptide repeat containing 3 / Q6ZXV5*ENSMUSG0000003667613
Tmtc4 / Q8BG19 / Transmembrane and TPR repeat-containing protein 4 / Q5T4D3* / transmembrane and tetratricopeptide repeat containing 4*ENSMUSG0000004159412
Tmtc2 / Q56A06 / transmembrane and tetratricopeptide repeat containing 2 / Q8N394*ENSMUSG0000003601911


Protein motifs (from Interpro)
Interpro ID Name
 IPR001440  Tetratricopeptide repeat 1
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR029489  O-GlcNAc transferase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006110 regulation of glycolytic process IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006493 protein O-linked glycosylation TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0035020 regulation of Rac protein signal transduction IEA
 biological_processGO:0043981 histone H4-K5 acetylation IEA
 biological_processGO:0043982 histone H4-K8 acetylation IEA
 biological_processGO:0043984 histone H4-K16 acetylation IEA
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046626 regulation of insulin receptor signaling pathway IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0061087 positive regulation of histone H3-K27 methylation IEA
 biological_processGO:0080182 histone H3-K4 trimethylation IEA
 cellular_componentGO:0000123 histone acetyltransferase complex IEA
 cellular_componentGO:0005622 intracellular TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0003824 catalytic activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0008080 N-acetyltransferase activity TAS
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016262 protein N-acetylglucosaminyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0043995 histone acetyltransferase activity (H4-K5 specific) IEA
 molecular_functionGO:0043996 histone acetyltransferase activity (H4-K8 specific) IEA
 molecular_functionGO:0046972 histone acetyltransferase activity (H4-K16 specific) IEA
 molecular_functionGO:0097363 protein O-GlcNAc transferase activity IMP


Pathways (from Reactome)
Pathway description
HATs acetylate histones
UCH proteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Dstdt-31J/Dstdt-31J
Genetic Background: DBA/1LacJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: OgtGt(BGA526)Byg/Y
Genetic Background: chimera involves: 129P2/OlaHsd

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ogttm1Gwh/Ogttm1Gwh,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Dstdt-31J/Dstdt-31J
Genetic Background: DBA/1LacJ

Allelic Composition: Ogttm1Gwh/Ogt+,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ogttm1Gwh/Y,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021901 Bap1 / Q99PU7 / Ubiquitin carboxyl-terminal hydrolase BAP1 / Q92560* / BRCA1 associated protein 1*  / complex / reaction
 ENSMUSG00000039275 Foxk2 / Q3UCQ1 / Forkhead box protein K2 / Q01167* / forkhead box K2*  / complex
 ENSMUSG00000021264 Yy1 / Q00899 / YY1 transcription factor / P25490*  / complex
 ENSMUSG00000031386 Hcfc1 / Q61191 / Host cell factor 1 HCF N-terminal chain 1 HCF N-terminal chain 2 HCF N-terminal chain 3 HCF N-terminal chain 4 HCF N-terminal chain 5 HCF N-terminal chain 6 HCF C-terminal c...  / complex
 ENSMUSG00000056493 Foxk1 / P42128 / Forkhead box protein K1 / P85037* / forkhead box K1*  / complex
 ENSMUSG00000042548 Asxl1 / P59598 / Putative Polycomb group protein ASXL1 / Q8IXJ9* / additional sex combs like 1, transcriptional regulator*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr