ENSG00000147162


Homo sapiens

Features
Gene ID: ENSG00000147162
  
Biological name :OGT
  
Synonyms : O15294 / OGT / O-linked N-acetylglucosamine (GlcNAc) transferase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q13.1
Gene start: 71533083
Gene end: 71575897
  
Corresponding Affymetrix probe sets: 207563_s_at (Human Genome U133 Plus 2.0 Array)   207564_x_at (Human Genome U133 Plus 2.0 Array)   209240_at (Human Genome U133 Plus 2.0 Array)   212307_s_at (Human Genome U133 Plus 2.0 Array)   220594_at (Human Genome U133 Plus 2.0 Array)   229787_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399729
Ensembl peptide - ENSP00000362805
Ensembl peptide - ENSP00000362824
NCBI entrez gene - 8473     See in Manteia.
OMIM - 300255
RefSeq - XM_017029908
RefSeq - NM_181672
RefSeq - NM_181673
RefSeq - XM_017029907
RefSeq Peptide - NP_858059
RefSeq Peptide - NP_858058
swissprot - O15294
swissprot - C9JZL3
Ensembl - ENSG00000147162
  
Related genetic diseases (OMIM): 300997 - Mental retardation, X-linked 106, 300997
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ogt.1ENSDARG00000105243Danio rerio
 ogt.1ENSDARG00000099455Danio rerio
 OGTENSGALG00000005425Gallus gallus
 OgtENSMUSG00000034160Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TMTC3 / Q6ZXV5 / transmembrane and tetratricopeptide repeat containing 3ENSG0000013932413
TMTC1 / Q8IUR5 / transmembrane and tetratricopeptide repeat containing 1ENSG0000013368713
TMTC4 / Q5T4D3 / transmembrane and tetratricopeptide repeat containing 4ENSG0000012524712
TMTC2 / Q8N394 / transmembrane and tetratricopeptide repeat containing 2ENSG0000017910411


Protein motifs (from Interpro)
Interpro ID Name
 IPR001440  Tetratricopeptide repeat 1
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR029489  O-GlcNAc transferase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006110 regulation of glycolytic process IDA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006493 protein O-linked glycosylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007584 response to nutrient TAS
 biological_processGO:0016485 protein processing IMP
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0031397 negative regulation of protein ubiquitination ISS
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032868 response to insulin IDA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0035020 regulation of Rac protein signal transduction IDA
 biological_processGO:0043981 histone H4-K5 acetylation IDA
 biological_processGO:0043982 histone H4-K8 acetylation IDA
 biological_processGO:0043984 histone H4-K16 acetylation IDA
 biological_processGO:0045862 positive regulation of proteolysis IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046626 regulation of insulin receptor signaling pathway IDA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0061087 positive regulation of histone H3-K27 methylation IMP
 biological_processGO:0080182 histone H3-K4 trimethylation IMP
 cellular_componentGO:0000123 histone acetyltransferase complex IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0008375 acetylglucosaminyltransferase activity TAS
 molecular_functionGO:0016262 protein N-acetylglucosaminyltransferase activity IMP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0043995 histone acetyltransferase activity (H4-K5 specific) IDA
 molecular_functionGO:0043996 histone acetyltransferase activity (H4-K8 specific) IDA
 molecular_functionGO:0046972 histone acetyltransferase activity (H4-K16 specific) IDA
 molecular_functionGO:0097363 protein O-GlcNAc transferase activity ISS


Pathways (from Reactome)
Pathway description
HATs acetylate histones
UCH proteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100811 YY1 / P25490 / YY1 transcription factor  / complex
 ENSG00000171456 ASXL1 / Q8IXJ9 / additional sex combs like 1, transcriptional regulator  / complex
 ENSG00000141568 FOXK2 / Q01167 / forkhead box K2  / complex
 ENSG00000164916 FOXK1 / P85037 / forkhead box K1  / complex
 ENSG00000143970 ASXL2 / Q76L83 / additional sex combs like 2, transcriptional regulator  / complex
 ENSG00000163930 BAP1 / Q92560 / BRCA1 associated protein 1  / reaction / complex
 ENSG00000172534 HCFC1 / P51610 / host cell factor C1  / complex






 

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