ENSMUSG00000056493


Mus musculus

Features
Gene ID: ENSMUSG00000056493
  
Biological name :Foxk1
  
Synonyms : Forkhead box protein K1 / Foxk1 / P42128
  
Possible biological names infered from orthology : forkhead box K1 / P85037
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 142401497
Gene end: 142462011
  
Corresponding Affymetrix probe sets: 10527101 (MoGene1.0st)   1421759_a_at (Mouse Genome 430 2.0 Array)   1434655_at (Mouse Genome 430 2.0 Array)   1451752_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143450
Ensembl peptide - ENSMUSP00000072616
NCBI entrez gene - 17425     See in Manteia.
MGI - MGI:1347488
RefSeq - NM_199068
RefSeq - XM_006504654
RefSeq Peptide - NP_951031
swissprot - A0A0G2JG71
swissprot - P42128
Ensembl - ENSMUSG00000056493
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxk1ENSDARG00000037872Danio rerio
 FOXK1ENSGALG00000004460Gallus gallus
 FOXK1ENSG00000164916Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxk2 / Q3UCQ1 / Forkhead box protein K2 / Q01167* / forkhead box K2*ENSMUSG0000003927550
Foxn3 / Q499D0 / Forkhead box protein N3 / O00409* / forkhead box N3*ENSMUSG0000003371314
Foxj3 / Q8BUR3 / Forkhead box protein J3 / Q9UPW0* / forkhead box J3*ENSMUSG0000003299813
Foxn2 / Mus musculus forkhead box N2 (Foxn2), transcript variant 3, mRNA. / P32314* / forkhead box N2*ENSMUSG0000003499813
Foxj2 / Q9ES18 / Forkhead box protein J2 / Q9P0K8* / forkhead box J2*ENSMUSG0000000315413
Foxj1 / Q61660 / Forkhead box protein J1 / Q92949* / forkhead box J1*ENSMUSG0000003422713
Foxn4 / Q8K3Q3 / Forkhead box protein N4 / Q96NZ1* / forkhead box N4*ENSMUSG0000004200213
Foxn1 / Q61575 / Forkhead box protein N1 / O15353* / forkhead box N1*ENSMUSG0000000205712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR001766  Fork head domain
 IPR008984  SMAD/FHA domain superfamily
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0009653 anatomical structure morphogenesis IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031011 Ino80 complex IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0002151 G-quadruplex RNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
UCH proteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Foxk1tm1Djg/Foxk1tm1Djg
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

Allelic Composition: Dmdmdx/Y,Foxk1tm1Djg/Foxk1tm1Djg
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
Show

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dmdmdx/Dmd+,Foxk1tm1Djg/Foxk1+
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Foxk1tm1Djg/Foxk1tm1Djg
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

Allelic Composition: Dmdmdx/Y,Foxk1tm1Djg/Foxk1tm1Djg
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Dmdmdx/Y,Foxk1tm1Djg/Foxk1tm1Djg
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Myogtm1Whk/Myogtm1Whk
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003852 skeletal muscle necrosis "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Foxk1tm1Djg/Foxk1tm1Djg
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

Allelic Composition: Dmdmdx/Y,Foxk1tm1Djg/Foxk1tm1Djg
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

Allelic Composition: Dmdmdx/Dmd+,Foxk1tm1Djg/Foxk1+
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Foxk1tm1Djg/Foxk1tm1Djg
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

Allelic Composition: Dmdmdx/Y,Foxk1tm1Djg/Foxk1tm1Djg
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Foxk1tm1Djg/Foxk1tm1Djg
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

Allelic Composition: Dmdmdx/Y,Foxk1tm1Djg/Foxk1tm1Djg
Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021901 Bap1 / Q99PU7 / Ubiquitin carboxyl-terminal hydrolase BAP1 / Q92560* / BRCA1 associated protein 1*  / reaction / complex
 ENSMUSG00000031386 Hcfc1 / Q61191 / Host cell factor 1 HCF N-terminal chain 1 HCF N-terminal chain 2 HCF N-terminal chain 3 HCF N-terminal chain 4 HCF N-terminal chain 5 HCF N-terminal chain 6 HCF C-terminal c...  / complex
 ENSMUSG00000034160 Ogt / Q8CGY8 / UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit / O15294* / O-linked N-acetylglucosamine (GlcNAc) transferase*  / complex
 ENSMUSG00000021264 Yy1 / Q00899 / YY1 transcription factor / P25490*  / complex
 ENSMUSG00000042548 Asxl1 / P59598 / Putative Polycomb group protein ASXL1 / Q8IXJ9* / additional sex combs like 1, transcriptional regulator*  / complex






 

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