ENSMUSG00000034227


Mus musculus

Features
Gene ID: ENSMUSG00000034227
  
Biological name :Foxj1
  
Synonyms : Forkhead box protein J1 / Foxj1 / Q61660
  
Possible biological names infered from orthology : forkhead box J1 / Q92949
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 116330704
Gene end: 116335399
  
Corresponding Affymetrix probe sets: 10393266 (MoGene1.0st)   1425291_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038351
NCBI entrez gene - 15223     See in Manteia.
MGI - MGI:1347474
RefSeq - NM_008240
RefSeq - XM_006532269
RefSeq Peptide - NP_032266
swissprot - Q61660
Ensembl - ENSMUSG00000034227
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 F1QDF8ENSDARG00000101919Danio rerio
 FOXJ1ENSGALG00000041025Gallus gallus
 FOXJ1ENSG00000129654Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxj2 / Q9ES18 / Forkhead box protein J2 / Q9P0K8* / forkhead box J2*ENSMUSG0000000315423
Foxj3 / Q8BUR3 / Forkhead box protein J3 / Q9UPW0* / forkhead box J3*ENSMUSG0000003299823
Foxk2 / Q3UCQ1 / Forkhead box protein K2 / Q01167* / forkhead box K2*ENSMUSG0000003927523
Foxk1 / P42128 / Forkhead box protein K1 / P85037* / forkhead box K1*ENSMUSG0000005649322
Foxn4 / Q8K3Q3 / Forkhead box protein N4 / Q96NZ1* / forkhead box N4*ENSMUSG0000004200220
Foxn3 / Q499D0 / Forkhead box protein N3 / O00409* / forkhead box N3*ENSMUSG0000003371319
Foxn1 / Q61575 / Forkhead box protein N1 / O15353* / forkhead box N1*ENSMUSG0000000205718
Foxn2 / Mus musculus forkhead box N2 (Foxn2), transcript variant 3, mRNA. / P32314* / forkhead box N2*ENSMUSG0000003499818


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0002508 central tolerance induction IMP
 biological_processGO:0002635 negative regulation of germinal center formation IMP
 biological_processGO:0002897 positive regulation of central B cell tolerance induction IMP
 biological_processGO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006959 humoral immune response IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007420 brain development IEP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0030856 regulation of epithelial cell differentiation IDA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0033085 negative regulation of T cell differentiation in thymus IMP
 biological_processGO:0035089 establishment of apical/basal cell polarity IMP
 biological_processGO:0035502 metanephric part of ureteric bud development IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0044458 motile cilium assembly IMP
 biological_processGO:0045409 negative regulation of interleukin-6 biosynthetic process IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050869 negative regulation of B cell activation IMP
 biological_processGO:0050900 leukocyte migration IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0060428 lung epithelium development IEA
 biological_processGO:0060429 epithelium development IEP
 biological_processGO:0060972 left/right pattern formation IMP
 biological_processGO:0072016 glomerular parietal epithelial cell development IEA
 biological_processGO:0090630 activation of GTPase activity IDA
 biological_processGO:1901248 positive regulation of lung ciliated cell differentiation IEA
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Dnah5b2b601Clo/Dnah5b2b601Clo
Genetic Background: C57BL/6J-Dnah5b2b601Clo

 MP:0000531 right pulmonary isomerism "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Foxj1tm1Bph/Foxj1tm1Bph,Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(Pbsn-cre)8113ANg/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb,Tg(FOXJ1-EGFP)85Leo/0
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Foxj1tm1.1Ctk/Foxj1tm1.2Ctk,Tg(FOXJ1-cre/ERT2)1Blh/0
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Foxj1tm1.1Ctk/Foxj1tm1.2Ctk,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Foxj1tm1.1(cre/ERT2/GFP)Htg/Foxj1tm1.1(cre/ERT2/GFP)Htg
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Foxj1tm1.1Ctk/Foxj1tm1.2Ctk,Tg(FOXJ1-cre/ERT2)1Blh/0
Genetic Background: involves: C57BL/6 * DBA

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dnah5b2b601Clo/Dnah5b2b601Clo
Genetic Background: C57BL/6J-Dnah5b2b601Clo

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0002766 situs inversus "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Foxj1tm1.1(cre/ERT2/GFP)Htg/Foxj1tm1.1(cre/ERT2/GFP)Htg
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb,Tg(FOXJ1-EGFP)85Leo/0
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6J

 MP:0004066 abnormal Henson s node morphology "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Foxj1b2b774Clo/Foxj1b2b774Clo
Genetic Background: C57BL/6J-Foxj1b2b774Clo

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Foxj1tm1Bph/Foxj1tm1Bph,Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxj1tm1.1Ctk/Foxj1tm1.2Ctk,Tg(FOXJ1-cre/ERT2)1Blh/0
Genetic Background: involves: C57BL/6 * DBA

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0008545 absent sperm flagella "mature spermatozoa lack a flagella" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxj1tm1.1Ctk/Foxj1tm1.2Ctk,Tg(FOXJ1-cre/ERT2)1Blh/0
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Foxj1tm1.1Ctk/Foxj1tm1.2Ctk,Tg(FOXJ1-EGFP)85Leo/0,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * SJL

 MP:0010152 abnormal brain ependyma morphology "any structural anomaly of the cellular membrane that lines the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0010541 aorta hypoplasia "underdevelopment or reduced size of the main trunk of the systemic arterial system that originates from the base of the left ventricle of the heart and extends to the abdomen at the point where it branches into the common iliac arteries, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Foxj1tm1Bph/Foxj1tm1Bph,Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0010807 abnormal stomach position or orientation "the stomach is displaced from the normal left-sided position and/or orientation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0010808 right-sided stomach "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Foxj1tm1Bph/Foxj1tm1Bph,Invsinv/Invsinv
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0010854 lung situs inversus "anomaly in the asymmetry of the lung such that lung lobes on both the left and right side have the morphology normally seen on the opposite side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd

 MP:0011054 absent respiratory motile cilia "absence of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0011057 absent brain ependyma motile cilia "absence of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Foxj1tm1Bph/Foxj1tm1Bph
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011252 situs inversus totalis "the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia)" [MGI:csmith]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Foxj1b2b774Clo/Foxj1b2b774Clo
Genetic Background: C57BL/6J-Foxj1b2b774Clo

 MP:0011645 absent oviduct epithelium motile cilium "absence of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the oviduct" [MGI:csmith]
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0011998 decreased embryonic cilium length "reduced length of the cilia of the mouse embryo found on the cells of the embryonic node" [MGI:csmith]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0012027 abnormal embryonic cilium location or orientation "embryonic cilia are displaced from the normal position and/or do not orient in a typical pattern" [MGI:csmith]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0012093 absent nodal flow "absence of the leftward movement of extra-embryonic fluid at the ventral node; nodal flow is autonomously generated by the rotation of cilia that are tilted toward the posterior on cells of the ventral node and is the central process in symmetry breaking on the left-right axis; when nodal cilia are immotile or absent, nodal flow does not occur" [MGI:anna]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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