ENSMUSG00000042002


Mus musculus

Features
Gene ID: ENSMUSG00000042002
  
Biological name :Foxn4
  
Synonyms : Forkhead box protein N4 / Foxn4 / Q8K3Q3
  
Possible biological names infered from orthology : forkhead box N4 / Q96NZ1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 114254164
Gene end: 114273807
  
Corresponding Affymetrix probe sets: 10532807 (MoGene1.0st)   1425254_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126361
Ensembl peptide - ENSMUSP00000047951
Ensembl peptide - ENSMUSP00000126256
NCBI entrez gene - 116810     See in Manteia.
MGI - MGI:2151057
RefSeq - XM_006530121
RefSeq - XM_006530122
RefSeq - XM_011248160
RefSeq - NM_148935
RefSeq Peptide - NP_683737
swissprot - Q8K3Q3
swissprot - E9PZL8
swissprot - F6ZBN9
Ensembl - ENSMUSG00000042002
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxn4ENSDARG00000010591Danio rerio
 FOXN4ENSGALG00000005062Gallus gallus
 FOXN4ENSG00000139445Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxn1 / Q61575 / Forkhead box protein N1 / O15353* / forkhead box N1*ENSMUSG0000000205738
Foxk1 / P42128 / Forkhead box protein K1 / P85037* / forkhead box K1*ENSMUSG0000005649318
Foxj2 / Q9ES18 / Forkhead box protein J2 / Q9P0K8* / forkhead box J2*ENSMUSG0000000315417
Foxj3 / Q8BUR3 / Forkhead box protein J3 / Q9UPW0* / forkhead box J3*ENSMUSG0000003299817
Foxk2 / Q3UCQ1 / Forkhead box protein K2 / Q01167* / forkhead box K2*ENSMUSG0000003927517
Foxn3 / Q499D0 / Forkhead box protein N3 / O00409* / forkhead box N3*ENSMUSG0000003371317
Foxn2 / Mus musculus forkhead box N2 (Foxn2), transcript variant 3, mRNA. / P32314* / forkhead box N2*ENSMUSG0000003499816
Foxj1 / Q61660 / Forkhead box protein J1 / Q92949* / forkhead box J1*ENSMUSG0000003422716


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008016 regulation of heart contraction ISS
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0035881 amacrine cell differentiation IMP
 biological_processGO:0036302 atrioventricular canal development ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0048663 neuron fate commitment IGI
 biological_processGO:0060579 ventral spinal cord interneuron fate commitment IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002984 retina hypoplasia "less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006070 increased retinal photoreceptor number "greater than the expected number of rods and/or cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008106 decreased amacrine cell number "reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008107 absent horizontal cells "absence of the laterally interconnecting neurons in the outer plexiform layer of the retina that connect rods of one part of the retina with cones in another part of the retina" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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