Manteia

ENSMUSG00000002057

Mus musculus

Features

Gene ID:	ENSMUSG00000002057

Biological name :	Foxn1

Synonyms :	Forkhead box protein N1 / Foxn1 / Q61575

Possible biological names infered from orthology :	forkhead box N1 / O15353

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	B5
Gene start:	78357577
Gene end:	78386558

Corresponding Affymetrix probe sets:	10388824 (MoGene1.0st) 1450508_at (Mouse Genome 430 2.0 Array) 1456815_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000103929 NCBI entrez gene - 15218 See in Manteia. MGI - MGI:102949 RefSeq - XM_017314292 RefSeq - NM_001277290 RefSeq - NM_008238 RefSeq - XM_017314288 RefSeq - XM_017314289 RefSeq - XM_017314290 RefSeq - XM_017314291 RefSeq - XM_006532264 RefSeq - XM_006532265 RefSeq - XM_006532266 RefSeq - XM_006532267 RefSeq - XM_006532268 RefSeq - XM_017314283 RefSeq - XM_017314284 RefSeq - XM_017314285 RefSeq - XM_017314286 RefSeq - XM_017314287 RefSeq Peptide - NP_032264 RefSeq Peptide - NP_001264219 swissprot - Q5SYK1 swissprot - Q61575 Ensembl - ENSMUSG00000002057

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
foxn1	ENSDARG00000011879	Danio rerio
FOXN1	ENSGALG00000043868	Gallus gallus
FOXN1	ENSG00000109101	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Foxn4 / Q8K3Q3 / Forkhead box protein N4 / Q96NZ1* / forkhead box N4*	ENSMUSG00000042002	31
Foxj3 / Q8BUR3 / Forkhead box protein J3 / Q9UPW0* / forkhead box J3*	ENSMUSG00000032998	16
Foxn3 / Q499D0 / Forkhead box protein N3 / O00409* / forkhead box N3*	ENSMUSG00000033713	15
Foxj2 / Q9ES18 / Forkhead box protein J2 / Q9P0K8* / forkhead box J2*	ENSMUSG00000003154	14
Foxk1 / P42128 / Forkhead box protein K1 / P85037* / forkhead box K1*	ENSMUSG00000056493	13
Foxn2 / Mus musculus forkhead box N2 (Foxn2), transcript variant 3, mRNA. / P32314* / forkhead box N2*	ENSMUSG00000034998	13
Foxk2 / Q3UCQ1 / Forkhead box protein K2 / Q01167* / forkhead box K2*	ENSMUSG00000039275	13
Foxj1 / Q61660 / Forkhead box protein J1 / Q92949* / forkhead box J1*	ENSMUSG00000034227	12

Protein motifs (from Interpro)

Interpro ID	Name
IPR001766	Fork head domain
IPR030456	Fork head domain conserved site 2
IPR036388	Winged helix-like DNA-binding domain superfamily
IPR036390	Winged helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001942	hair follicle development	IMP
biological_process	GO:0002260	lymphocyte homeostasis	IMP
biological_process	GO:0002360	T cell lineage commitment	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0008283	cell proliferation	IDA
biological_process	GO:0008544	epidermis development	IMP
biological_process	GO:0010468	regulation of gene expression	IMP
biological_process	GO:0030097	hemopoiesis	IMP
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030216	keratinocyte differentiation	IDA
biological_process	GO:0030858	positive regulation of epithelial cell differentiation	IEA
biological_process	GO:0033081	regulation of T cell differentiation in thymus	IMP
biological_process	GO:0035878	nail development	IMP
biological_process	GO:0043029	T cell homeostasis	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0048514	blood vessel morphogenesis	IMP
biological_process	GO:0048538	thymus development	IMP
biological_process	GO:0050673	epithelial cell proliferation	IDA
biological_process	GO:0051798	positive regulation of hair follicle development	IMP
biological_process	GO:0097535	lymphoid lineage cell migration into thymus	IMP
biological_process	GO:0097536	thymus epithelium morphogenesis	IMP
biological_process	GO:1902232	regulation of positive thymic T cell selection	IMP
cellular_component	GO:0005634	nucleus	IBA
molecular_function	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IDA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000062	increased bone density	"increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Nr1h4^tm1Gonz/Nr1h4^tm1Gonz Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nr1h4^tm1Gonz/Nr1h4^tm1Gonz Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000217	abnormal white blood cell count	"anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxn1^nu-Y/Foxn1^nu-Y Genetic Background: 101/HY-Foxn1^nu-Y
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified Allelic Composition: Dh/Dh⁺,Foxn1^nu/Foxn1^nu Genetic Background: involves: N:NIH(S) Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: CBA
MP:0000322	increased granulocyte number	"greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoa1^{tm1(APOA1)Prli}/Apoa1^{tm2(APOA1)Prli} Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000367	abnormal coat/ hair morphology	"anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kitl^Sl-pan/Kitl^Sl-pan Genetic Background: involves: C3H
MP:0000377	abnormal hair follicle	"malformed invagination of the epidermis from which the hair shaft develops" [J:65031]	Show Allelic Composition: Kitl^Sl-pan/Kitl^Sl-pan Genetic Background: involves: C3H
MP:0000382	underdeveloped hair follicles	"arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]	Show Allelic Composition: Ar^Tfm/Y Genetic Background: involves: STOCK Eda^Ta Atp7a^Mo-blo Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ
MP:0000579	abnormal nail morphology	"structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kitl^Sl-pan/Kitl^Sl-pan Genetic Background: involves: C3H Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: NU/J Allelic Composition: Foxn1^nu/Foxn1^nu,Msx2^tm1Rilm/Msx2^tm1Rilm Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1
MP:0000580	deformed nails	"atypical shape or size of the nails" [J:45400]	Show Allelic Composition: Kitl^Sl-pan/Kitl^Sl-pan Genetic Background: involves: C3H Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c Allelic Composition: Foxn1^nu/Foxn1^nu,Msx2^tm1Rilm/Msx2^tm1Rilm Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Gabrg2^tm2Lusc/Gabrg2^tm2Lusc,Tg(Camk2a-cre)T50Stl/0 Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6
MP:0000685	abnormal immune system morphology	"morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoa1^{tm1(APOA1)Prli}/Apoa1^{tm2(APOA1)Prli} Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0000690	absent spleen	"missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Smarcb1^tm1Sho/Smarcb1^tm3Sho,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Apoa1^{tm1(APOA1)Prli}/Apoa1^{tm2(APOA1)Prli} Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000696	abnormal Peyer s patches morphology	"anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoa1^{tm1(APOA1)Prli}/Apoa1^{tm2(APOA1)Prli} Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Dh/Dh⁺,Foxn1^nu/Foxn1^nu Genetic Background: involves: N:NIH(S)
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Foxn1^nu-Y/Foxn1^nu-Y Genetic Background: 101/HY-Foxn1^nu-Y Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified Allelic Composition: Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129/Sv * C57BL/6 * CBA * SJL Allelic Composition: Dicer1^tm1Tara/Dicer1^tm1Tara,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd Allelic Composition: Foxn1^nu/Foxn1⁺ Genetic Background: NFS.Cg-Foxn1^nu
MP:0000704	abnormal thymus development	"anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^nu-StL/Foxn1^nu-StL Genetic Background: involves: C57BL/6 Allelic Composition: Foxn1^tm1Tbo/Foxn1^tm1Tbo Genetic Background: involves: 129S1/Sv Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI Allelic Composition: Foxn1^tm1Nrm/Foxn1^tm1Nrm Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Foxn1^nu-StL/Foxn1^tm1Tbo Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: C57BL/10Sn * C57BR/cd Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd
MP:0000705	athymia	"absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Yes1^tm2Sor/Yes1^tm2Sor Genetic Background: either: 129S7/SvEvBrd-Yes1^tm2Sor or (involves: 129S7/SvEvBrd * C57BL/6) Allelic Composition: Foxn1^nu-StL/Foxn1^nu-StL Genetic Background: involves: C57BL/6 Allelic Composition: Foxn1^nu-Y/Foxn1^nu-Y Genetic Background: 101/HY-Foxn1^nu-Y Allelic Composition: Foxn1^tm1Tbo/Foxn1^tm1Tbo Genetic Background: involves: 129S1/Sv Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified Allelic Composition: Foxn1^nu-StL/Foxn1^tm1Tbo Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Dh/Dh⁺,Foxn1^nu/Foxn1^nu Genetic Background: involves: N:NIH(S) Allelic Composition: Foxn1^nu/Foxn1^nu,Map3k14^aly/Map3k14^aly Genetic Background: involves: BALB/cAJcl * C57BL/6J Allelic Composition: Foxn1^tm1Dmsu/Foxn1^tm1Dmsu Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: CD-1 Allelic Composition: Foxn1^sepe/Foxn1^sepe Genetic Background: BALB/c-Foxn1^sepe
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Foxn1^tm1Nrm/Foxn1^tm1Nrm Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Foxn1^nu/Foxn1⁺ Genetic Background: C.Cg-Foxn1^nu Allelic Composition: Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129/Sv * C57BL/6 * CBA * SJL Allelic Composition: Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu,Tg(KRT5-cre/ERT2)2Ipc/0 Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Foxn1^tm1.1Cbln/Foxn1^tm1Tbo Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 Allelic Composition: Foxn1^nu/Foxn1⁺ Genetic Background: NFS.Cg-Foxn1^nu Allelic Composition: Foxn1^nu/Foxn1⁺ Genetic Background: B6N.Cg-Foxn1^nu Allelic Composition: Foxn1^nu/Foxn1⁺ Genetic Background: C3N.Cg-Foxn1^nu
MP:0000708	thymus hyperplasia	"increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Smad4^tm2.1Cxd/Smad4^tm2.1Cxd,Tg(ACTA1-cre)AMcle/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxn1^tm1Nrm/Foxn1^tm1Nrm Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Dll4^tm1Frad/Dll4^tm1Frad,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: B6.Cg-Dll4^tm1Frad Foxn1^tm3(cre)Nrm Allelic Composition: Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129/Sv * C57BL/6 * CBA * SJL Allelic Composition: Foxn1^nu/Foxn1^tm1.1Dmsu,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129/Sv * C57BL/6 * CBA * SJL Allelic Composition: Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu,Tg(KRT5-cre/ERT2)2Ipc/0 Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd
MP:0000716	abnormal immune system cell morphology	"anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoa1^{tm1(APOA1)Prli}/Apoa1^{tm2(APOA1)Prli} Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0000717	abnormal lymphocyte number	"deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Smad4^tm2.1Cxd/Smad4^tm2.1Cxd,Tg(ACTA1-cre)AMcle/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001127	small ovary	"reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0001199	thin skin	"reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0001211	wrinkled skin	"irregular folds and/or indentations on the skin" [J:19212]	Show Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ
MP:0001216	abnormal epidermal layer morphology	"anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kitl^Sl-pan/Kitl^Sl-pan Genetic Background: involves: C3H
MP:0001231	abnormal basal cell layer morphology	"structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kitl^Sl-pan/Kitl^Sl-pan Genetic Background: involves: C3H
MP:0001239	abnormal granular layer morphology	"structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kitl^Sl-pan/Kitl^Sl-pan Genetic Background: involves: C3H
MP:0001240	abnormal cornified layer morphology	"structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kitl^Sl-pan/Kitl^Sl-pan Genetic Background: involves: C3H
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Foxn1^nu-StL/Foxn1^nu-StL Genetic Background: involves: C57BL/6 Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Gabrg2^tm2Lusc/Gabrg2^tm2Lusc,Tg(Camk2a-cre)T50Stl/0 Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6 Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ
MP:0001273	decreased metastatic potential		Show Allelic Composition: Tyrp1^rgsc101/Tyrp1^rgsc101 Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl
MP:0001274	curly vibrissae	"whiskers twisted into coils or spirals" [J:47620]	Show Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ
MP:0001279	wavy vibrissae	"whiskers having undulations or a sinusoidal shape" [J:65044]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0001282	short vibrissae	"decreased length of the vibrissae" [J:30249]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ
MP:0001283	sparse vibrissae	"few and widely spaced whiskers" [J:65302]	Show Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ
MP:0001284	absent vibrissae	"missing whiskers" [J:18378]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ
MP:0001313	increased incidence of corneal inflammation	"greater than average and persistent occurrence of corneal irritation" [J:4606]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: NU/J
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoa1^{tm1(APOA1)Prli}/Apoa1^{tm2(APOA1)Prli} Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0001800	abnormal humoral immune response	"abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Apoa1^{tm1(APOA1)Prli}/Apoa1^{tm2(APOA1)Prli} Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Smad4^tm2.1Cxd/Smad4^tm2.1Cxd,Tg(ACTA1-cre)AMcle/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd
MP:0001824	abnormal thymic involution	"premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dpysl2^tm1.1Gosh/Dpysl2^tm1.1Gosh,Tg(Thy1-YFP)HJrs/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA * FVB/N Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Foxn1/ERT2,-GFP)Cbln}/Gt(ROSA)26Sor⁺,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001828	abnormal T cell activation	"anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: CBA
MP:0001876	decreased inflammatory response	"less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^nu/Foxn1^nu,Tgfb1^tm1Doe/Tgfb1^tm1Doe Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Yes1^tm2Sor/Yes1^tm2Sor Genetic Background: either: 129S7/SvEvBrd-Yes1^tm2Sor or (involves: 129S7/SvEvBrd * C57BL/6)
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0001927	abnormal oestrous cycle (sensu Rodentia)	"failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ
MP:0002032	sarcoma	"connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Apoa1^{tm1(APOA1)Prli}/Apoa1^{tm2(APOA1)Prli} Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0002052	decreased tumor incidence	"less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kit^tm1Ber/Kit⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002073	abnormal hair growth	"absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Olfr17^tm1Mom/Olfr17⁺,Ttc8^tm1Reed/Ttc8^tm1Reed Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 Allelic Composition: Foxn1^tm1.1Cbln/Foxn1^tm1Tbo Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Apoa1^{tm1(APOA1)Prli}/Apoa1^{tm2(APOA1)Prli} Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified Allelic Composition: Foxn1^nu/Foxn1^nu,Tgfb1^tm1Doe/Tgfb1^tm1Doe Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1 Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NIH Swiss
MP:0002085	abnormal embryonic tissue morphology	"structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kitl^Sl-pan/Kitl^Sl-pan Genetic Background: involves: C3H
MP:0002095	abnormal skin pigmentation	"variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ar^Tfm/Y Genetic Background: involves: STOCK Eda^Ta Atp7a^Mo-blo
MP:0002098	abnormal vibrissae morphology	"irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ
MP:0002108	abnormal muscle morphology	"abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^nu/Foxn1⁺ Genetic Background: C3N.Cg-Foxn1^nu Allelic Composition: Dmd^mdx/Y,Foxn1^nu/Foxn1^nu Genetic Background: involves: C57BL/10ScSn
MP:0002145	abnormal T lymphocyte development	"atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified Allelic Composition: Dll4^tm1Frad/Dll4^tm1Frad,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: B6.Cg-Dll4^tm1Frad Foxn1^tm3(cre)Nrm
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified Allelic Composition: Foxn1^nu/Foxn1^nu,Ivl^tm1Dji/Ivl^tm1Dji Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 Allelic Composition: Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0002339	abnormal lymph node morphology	"anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gt(ROSA)26Sor^{tm5(H1/tetO-RNAi:Ezh2)Arte}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * FVB
MP:0002347	abnormal lymph node T cell domain	"anomaly in the area of the lymph node in which T lymphocytes reside" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0002371	abnormal thymus cortex morphology	"anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dicer1^tm1Tara/Dicer1^tm1Tara,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd
MP:0002375	abnormal thymus medulla morphology	"anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu,Tg(KRT5-cre/ERT2)2Ipc/0 Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Dicer1^tm1Tara/Dicer1^tm1Tara,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd
MP:0002391	abnormal Peyer s patch germinal center morphology	"anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0002410	decreased susceptibility to viral infection	"reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Oca2^p-dn/Oca2^p-dn Genetic Background: Not Specified
MP:0002411	decreased susceptibility to bacterial infection	"reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c
MP:0002418	increased susceptibility to viral infection	"greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c Allelic Composition: Foxn1^nu/Foxn1⁺ Genetic Background: involves: BALB/c
MP:0002432	abnormal CD4+ T cell morphology/development	"anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^tm1Nrm/Foxn1^tm1Nrm Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0002444	abnormal T cell physiology	"anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^nu/Foxn1^nu,Tgfb1^tm1Doe/Tgfb1^tm1Doe Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1
MP:0002460	decreased circulating immunoglobulin concentration	"less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J
MP:0002495	increased IgA	"greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dh/Dh⁺,Foxn1^nu/Foxn1^nu Genetic Background: involves: N:NIH(S)
MP:0002675	asthenozoospermia	"loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J
MP:0002773	decreased circulating luteinizing hormone level	"lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: CD-1
MP:0002790	decreased circulating follicle stimulating hormone level	"less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: CD-1
MP:0002831	absent Peyer s patches	"lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxn1^nu/Foxn1^nu,Map3k14^aly/Map3k14^aly Genetic Background: involves: BALB/cAJcl * C57BL/6J
MP:0002942	decreased circulating alanine transaminase level	"decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c
MP:0003135	increased erythrocyte precursors	"greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dh/Dh⁺,Foxn1^nu/Foxn1^nu Genetic Background: involves: N:NIH(S)
MP:0003361	abnormal circulating gonadotropin level	"aberrant blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: CD-1
MP:0003638	abnormal response/metabolism to endogenous compounds	"altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tyrp1^rgsc101/Tyrp1^rgsc101 Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl
MP:0003644	thymus atrophy	"wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129/Sv * C57BL/6 * CBA * SJL Allelic Composition: Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu,Tg(KRT5-cre/ERT2)2Ipc/0 Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0003704	abnormal hair follicle development	"anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^tm1Tbo/Foxn1^tm1Tbo Genetic Background: involves: 129S1/Sv
MP:0003724	susceptibility to induced arthritis	"more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Dicer1^tm1Tara/Dicer1^tm1Tara,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd
MP:0003763	abnormal thymus physiology	"anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Dicer1^tm1Tara/Dicer1^tm1Tara,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd
MP:0003797	abnormal compact bone morphology	"structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Nr1h4^tm1Gonz/Nr1h4^tm1Gonz Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0003809	abnormal hair shaft morphology	"irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0003810	abnormal hair cuticle	"anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0003811	abnormal hair cortex	"anomalies in the spindle shaped cells of the hair shaft that contains keratin fibrils and matrix" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0003815	nude	"having no hair at some time during or throughout lifespan, generally referring to primary genetic hairlessness" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Yes1^tm2Sor/Yes1^tm2Sor Genetic Background: either: 129S7/SvEvBrd-Yes1^tm2Sor or (involves: 129S7/SvEvBrd * C57BL/6) Allelic Composition: Foxn1^nu/Foxn1^nu,Tg(Foxn1)G2Hon/0 Genetic Background: involves: CD-1 Allelic Composition: Foxn1^nu-StL/Foxn1^nu-StL Genetic Background: involves: C57BL/6 Allelic Composition: Foxn1^nu-Y/Foxn1^nu-Y Genetic Background: 101/HY-Foxn1^nu-Y Allelic Composition: Foxn1^tm1Tbo/Foxn1^tm1Tbo Genetic Background: involves: 129S1/Sv Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J Allelic Composition: Foxn1^tw/Foxn1^tw Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified Allelic Composition: Foxn1^tm2Tbo/Foxn1^tm2Tbo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Foxn1^tm1Dmsu/Foxn1^tm1Dmsu Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Foxn1^nu-Bc/Foxn1^nu-Bc Genetic Background: involves: SELH/Bc Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ Allelic Composition: Foxn1^sepe/Foxn1^sepe Genetic Background: BALB/c-Foxn1^sepe
MP:0003848	brittle hair	"hair is susceptible to breakage " [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ
MP:0004125	abnormal venule morphology	"any structural anomaly in the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0004502	decreased incidence of chemically-induced tumors	"lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J
MP:0004751	increased length of allograft survival	"compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: CBA
MP:0004819	decreased skeletal muscle mass	"reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1⁺ Genetic Background: C3N.Cg-Foxn1^nu
MP:0004919	abnormal positive T cell selection	"any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]	Show Allelic Composition: Dicer1^tm1Tara/Dicer1^tm1Tara,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd
MP:0005010	abnormal CD8+ T cell morphology/development	"anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxn1^tm1Nrm/Foxn1^tm1Nrm Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0005011	increased eosinophil count	"greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^tm1Tbo/Foxn1^tm1Tbo Genetic Background: involves: 129S1/Sv
MP:0005015	increased T cell number	"greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^tm2Tbo/Foxn1^tm2Tbo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Foxn1/ERT2,-GFP)Cbln}/Gt(ROSA)26Sor⁺,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: CBA
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J Allelic Composition: Foxn1^tm1Nrm/Foxn1^tm1Nrm Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Foxn1^nu/Foxn1^nu,Map3k14^aly/Map3k14^aly Genetic Background: involves: BALB/cAJcl * C57BL/6J Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: CBA
MP:0005026	decreased susceptibility to parasitic infection	"reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ciita^tm1Ccum/Ciita^tm1Ccum Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0005089	decreased double-negative T cell count	"reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxn1^tm1Nrm/Foxn1^tm1Nrm Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0005091	increased double-positive T cell count	"greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Smad4^tm2.1Cxd/Smad4^tm2.1Cxd,Tg(ACTA1-cre)AMcle/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Foxn1^tm1Nrm/Foxn1^tm1Nrm Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Dll4^tm1Frad/Dll4^tm1Frad,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: B6.Cg-Dll4^tm1Frad Foxn1^tm3(cre)Nrm Allelic Composition: Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129/Sv * C57BL/6 * CBA * SJL
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J
MP:0005251	blepharitis	"inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c Allelic Composition: Foxn1^nu/Foxn1⁺ Genetic Background: involves: BALB/c
MP:0005324	ascites	"accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c
MP:0005505	increased platelet count	"greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dh/Dh⁺,Foxn1^nu/Foxn1^nu Genetic Background: involves: N:NIH(S)
MP:0005542	corneal vascularization	"formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Foxn1^nu/Foxn1⁺ Genetic Background: involves: BALB/c
MP:0008024	absent lymph nodes	"absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu,Map3k14^aly/Map3k14^aly Genetic Background: involves: BALB/cAJcl * C57BL/6J
MP:0008070	absent T cells	"absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu-StL/Foxn1^nu-StL Genetic Background: involves: C57BL/6 Allelic Composition: Foxn1^nu-Y/Foxn1^nu-Y Genetic Background: 101/HY-Foxn1^nu-Y Allelic Composition: Foxn1^tm1Tbo/Foxn1^tm1Tbo Genetic Background: involves: 129S1/Sv Allelic Composition: Foxn1^tm1.1Cbln/Foxn1^tm1Tbo Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0008071	absent B cells	"absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu,Map3k14^aly/Map3k14^aly Genetic Background: involves: BALB/cAJcl * C57BL/6J
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^tm1Nrm/Foxn1^tm1Nrm Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Dll4^tm1Frad/Dll4^tm1Frad,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: B6.Cg-Dll4^tm1Frad Foxn1^tm3(cre)Nrm Allelic Composition: Dicer1^tm1Tara/Dicer1^tm1Tara,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dll4^tm1Frad/Dll4^tm1Frad,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: B6.Cg-Dll4^tm1Frad Foxn1^tm3(cre)Nrm Allelic Composition: Dicer1^tm1Tara/Dicer1^tm1Tara,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd
MP:0008083	decreased single-positive T cell number	"reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smad4^tm2.1Cxd/Smad4^tm2.1Cxd,Tg(ACTA1-cre)AMcle/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0008101	lymph node hypoplasia	"underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J
MP:0008214	increased immature B cell number	"greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dll4^tm1Frad/Dll4^tm1Frad,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: B6.Cg-Dll4^tm1Frad Foxn1^tm3(cre)Nrm
MP:0008351	decreased gamma-delta intraepithelial T cell number	"reduced number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]	Show Allelic Composition: Foxn1^nu/Foxn1^nu,Map3k14^aly/Map3k14^aly Genetic Background: involves: BALB/cAJcl * C57BL/6J
MP:0008438	abnormal cutaneous collagen fibril morphology	"any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0008554	decreased circulating tumor necrosis factor level	"reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c
MP:0008597	decreased circulating interleukin-6 level	"reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c
MP:0008600	decreased circulating interleukin-2 level	"reduction in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c
MP:0008732	reduced hair shaft melanin granule number	"the number of pigment polymers in the hair shaft is less than normal" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0008737	abnormal spleen physiology	"any anomaly in the function of the organ that filters blood and stores red corpuscles and platelets" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: CBA
MP:0008826	abnormal splenic cell ratio	"deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0008827	abnormal thymus cell ratio	"deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Dll4^tm1Frad/Dll4^tm1Frad,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: B6.Cg-Dll4^tm1Frad Foxn1^tm3(cre)Nrm
MP:0008866	chromosomal instability	"abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c
MP:0009238	coiled sperm flagellum	"abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0009399	increased skeletal muscle fiber size	"increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dmd^mdx/Y,Foxn1^nu/Foxn1^nu Genetic Background: involves: C57BL/10ScSn
MP:0009400	decreased skeletal muscle fiber size	"decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1⁺ Genetic Background: C3N.Cg-Foxn1^nu Allelic Composition: Dmd^mdx/Y,Foxn1^nu/Foxn1^nu Genetic Background: involves: C57BL/10ScSn
MP:0009541	increased thymocyte apoptosis	"increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^tm1.1Dmsu,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129/Sv * C57BL/6 * CBA * SJL
MP:0009543	abnormal thymus corticomedullary boundary morphology	"any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]	Show Allelic Composition: Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu,Tg(KRT5-cre/ERT2)2Ipc/0 Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0009544	abnormal thymus epithelium morphology	"any structural anomaly of the supporting framework of the thymus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]	Show Allelic Composition: Foxn1^tm1Tbo/Foxn1^tm1Tbo Genetic Background: involves: 129S1/Sv Allelic Composition: Foxn1^tm1Nrm/Foxn1^tm1Nrm Genetic Background: involves: 129X1/SvJ * C57BL/6J Allelic Composition: Foxn1^nu/Foxn1^tm1.1Dmsu,Tg(CAG-cre/Esr1)5Amc/0 Genetic Background:* involves: 129/Sv * C57BL/6 * CBA * SJL Allelic Composition: Dicer1^tm1Tara/Dicer1^tm1Tara,Foxn1^tm3(cre)Nrm/Foxn1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6NHsd Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd
MP:0009791	increased susceptibility to viral infection induced morbidity/mortality	"increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c
MP:0009801	abnormal hair cortex keratinization	"any defect in the formation of the fibrous elements found in the hair cortex comprising acidic (Type I ) and basic (Type II) proteins that give hair such aspects as resilience, and elasticity" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0010129	increased DN1 thymic pro-T cell number	"increased number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]	Show Allelic Composition: Smad4^tm2.1Cxd/Smad4^tm2.1Cxd,Tg(ACTA1-cre)AMcle/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0010210	abnormal circulating cytokine level	"deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c
MP:0010250	absent thymus cortex	"lacking the outer part of the thymus lobule which surrounds the medulla and is normally composed of closely packed lymphocytes" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^tm1Nrm/Foxn1^tm1Nrm Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0010268	decreased lymphoma incidence	"less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu-str/Foxn1^nu-str Genetic Background: AKR/J-Foxn1^nu-str/J
MP:0010286	increased plasmacytoma incidence	"greater than the expected number of neoplastic plasma cells in bone or in one of the extramedullary sites occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c
MP:0010681	abnormal hair follicle bulb morphology	"any structural anomaly of the thickened portion of the proximal portion of the hair follicle that contains rapidly proliferating matrix cells, melanocytes and outer root sheath cells" [PMID:19211055]	Show Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ
MP:0010685	abnormal hair follicle inner root sheath morphology	"any structural anomaly of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle s layer, Huxley s layer and the inner root sheath cuticle" [PMID:19211055]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Foxn1^nu-Y/Foxn1^nu-Y Genetic Background: 101/HY-Foxn1^nu-Y Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Foxn1^nu-2J/Foxn1^nu-2J Genetic Background: B6(SJL)-Foxn1^nu-2J/GrsrJ
MP:0012307	impaired spatial learning	"impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: Not Specified
MP:0012399	short nails	"decrease in the length of the nails" [MGI:smb]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: BALB/c Allelic Composition: Foxn1^nu/Foxn1^nu,Msx2^tm1Rilm/Msx2^tm1Rilm Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1
MP:0012400	nail dystrophy	"the presence of misshapen or partially destroyed nail plates, fequently with keratin often accumulating between the dystrophic nail plate and nail bed; often due to trauma or infection" [MGI:smb]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: NU/J
MP:0012402	abnormal nail bed morphology	"any structural anomaly of the dermis and epidermis directly below the nail plate" [MGI:smb]	Show Allelic Composition: Foxn1^nu/Foxn1^nu,Msx2^tm1Rilm/Msx2^tm1Rilm Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1
MP:0012403	abnormal nail plate morphology	"any structural anomally of the hard and translucent portion of the nail, composed of keratin, which serves to protect the tips of digits" [GO:0035880, MGI:smb]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: NU/J Allelic Composition: Foxn1^nu/Foxn1^nu,Msx2^tm1Rilm/Msx2^tm1Rilm Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1
MP:0012405	abnormal nail matrix morphology	"any structural anomaly of the nail-forming area of the nail bed comprised of a germinal matrix, responsible for most of the nail production, and the sterile matrix, a secondary site of nail production which is tightly adherent to the nail plate" [MGI:smb]	Show Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: involves: NMRI Allelic Composition: Foxn1^nu/Foxn1^nu Genetic Background: NU/J Allelic Composition: Foxn1^nu/Foxn1^nu,Msx2^tm1Rilm/Msx2^tm1Rilm Genetic Background: involves: 129S4/SvJae * BALB/c * CD-1
MP:0013225	abnormal third pharyngeal pouch morphology	"any structural anomaly of the third endodermal branchial pouch located between the third and fourth branchial arches; in mammals, the cranial dorsal aspect of the third pouch generates the inferior parathyroids (or parathyroid III), whereas the caudal ventral part of the pouch gives rise to the thymus epithelium" [PMID:20144910]	Show Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺,Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺ Genetic Background: involves: C57BL/6 * C57BL/6NHsd
MP:0013587	absent thymus medulla	"lacking the inner area of thymus lobules" [MGI:Anna]	Show Allelic Composition: Foxn1^tm1Nrm/Foxn1^tm1Nrm Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0014130	thymus cysts	"presence of fluid-filled spaces lined by epithelium within the thymus; thymic cysts are rare mediastinal lesions and are thought to result from the congenital persistence of thymopharyngeal tracts and acquired, progressive cystic degeneration of thymic (Hassall) corpuscles and epithelial reticulum of the thymus; congenital cysts are unilocular, whereas acquired cysts are usually multilocular and result as a consequence of inflammatory processes" [http://www.pedsradiology.com/historyanswer.aspx?qid=408&fid=1, PMID:23050117]	Show Allelic Composition: Foxn1^tm1Nrm/Foxn1^tm1Nrm Genetic Background: involves: 129X1/SvJ * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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