ENSMUSG00000033713


Mus musculus

Features
Gene ID: ENSMUSG00000033713
  
Biological name :Foxn3
  
Synonyms : Forkhead box protein N3 / Foxn3 / Q499D0
  
Possible biological names infered from orthology : forkhead box N3 / O00409
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: E
Gene start: 99190078
Gene end: 99563582
  
Corresponding Affymetrix probe sets: 10402063 (MoGene1.0st)   10402066 (MoGene1.0st)   1434002_at (Mouse Genome 430 2.0 Array)   1436925_at (Mouse Genome 430 2.0 Array)   1438255_at (Mouse Genome 430 2.0 Array)   1453094_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152082
Ensembl peptide - ENSMUSP00000152328
Ensembl peptide - ENSMUSP00000036035
Ensembl peptide - ENSMUSP00000082189
Ensembl peptide - ENSMUSP00000135082
Ensembl peptide - ENSMUSP00000135749
Ensembl peptide - ENSMUSP00000135814
NCBI entrez gene - 71375     See in Manteia.
MGI - MGI:1918625
RefSeq - XM_017315205
RefSeq - XM_006516233
RefSeq - XM_006516234
RefSeq - XM_006516236
RefSeq - XM_006516239
RefSeq - XM_006516240
RefSeq - NM_183186
RefSeq - XM_006516232
RefSeq Peptide - NP_899009
swissprot - H3BLJ5
swissprot - A0A1Y7VMU1
swissprot - H3BLD8
swissprot - Q499D0
Ensembl - ENSMUSG00000033713
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxn3ENSDARG00000012833Danio rerio
 FOXN3ENSGALG00000010665Gallus gallus
 FOXN3ENSG00000053254Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Foxn2 / Mus musculus forkhead box N2 (Foxn2), transcript variant 3, mRNA. / P32314* / forkhead box N2*ENSMUSG0000003499841
Foxk2 / Q3UCQ1 / Forkhead box protein K2 / Q01167* / forkhead box K2*ENSMUSG0000003927521
Foxk1 / P42128 / Forkhead box protein K1 / P85037* / forkhead box K1*ENSMUSG0000005649321
Foxn1 / Q61575 / Forkhead box protein N1 / O15353* / forkhead box N1*ENSMUSG0000000205721
Foxj2 / Q9ES18 / Forkhead box protein J2 / Q9P0K8* / forkhead box J2*ENSMUSG0000000315420
Foxj3 / Q8BUR3 / Forkhead box protein J3 / Q9UPW0* / forkhead box J3*ENSMUSG0000003299820
Foxn4 / Q8K3Q3 / Forkhead box protein N4 / Q96NZ1* / forkhead box N4*ENSMUSG0000004200220
Foxj1 / Q61660 / Forkhead box protein J1 / Q92949* / forkhead box J1*ENSMUSG0000003422718


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR018122  Fork head domain conserved site1
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IBA
 biological_processGO:0097094 craniofacial suture morphogenesis IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000079 abnormal basioccipital bone morphology "malformed basilar process of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000106 abnormal basisphenoid bone morphology "malformed base of the sphenoid bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0005269 abnormal occipital bone morphology "anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0009891 abnormal palate bone morphology "any structural anomaly of the maxillary or palatine shelves that comprise the bones of the hard palate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0010743 delayed suture closure "late onset of the fusion of the bones of the skull" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0030082 long lower incisors "increased length or overgrowth of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0030083 long upper incisors "increased length or overgrowth of the upper set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0030279 thin neurocranium "decreased thickness of the bones of the skull enclosing the brain" [MGI:anna]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0030320 abnormal temporal bone tympanic part morphology "any structural anomaly of the curved plate of bone that is situated inferiorly to the squamous part and anteriorly to the mastoid part of the temporal bone; it surrounds the external auditory meatus, forming the anterior wall, floor and some of the posterior wall of the bony external acoustic meatus; its lateral border gives the attachment to the cartilaginous part of the external acoustic meatus; its anteroinferior surface forms the posterior boundary of the mandibular fossa" [https://en.wikipedia.org/wiki/Tympanic_part_of_the_temporal_bone, https://radiopaedia.org/articles/tympanic-part-of-temporal-bone]
Show

Allelic Composition: Tg(KRT5-cre/ERT2)2Ipc/0,Upf3atm1.1Wilk/Upf3atm1.1Wilk
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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