ENSG00000109101


Homo sapiens

Features
Gene ID: ENSG00000109101
  
Biological name :FOXN1
  
Synonyms : forkhead box N1 / FOXN1 / O15353
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q11.2
Gene start: 28506243
Gene end: 28538896
  
Corresponding Affymetrix probe sets: 1558687_a_at (Human Genome U133 Plus 2.0 Array)   207683_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000226247
Ensembl peptide - ENSP00000462159
Ensembl peptide - ENSP00000464645
NCBI entrez gene - 8456     See in Manteia.
OMIM - 600838
RefSeq - XM_017025231
RefSeq - NM_003593
RefSeq - XM_017025228
RefSeq - XM_017025229
RefSeq - XM_017025230
RefSeq - XM_005258046
RefSeq - XM_011525358
RefSeq - XM_011525359
RefSeq - XM_011525362
RefSeq - XM_011525367
RefSeq - XM_011525368
RefSeq - XM_011525369
RefSeq - XM_011525370
RefSeq Peptide - NP_003584
swissprot - O15353
swissprot - J3KRT9
Ensembl - ENSG00000109101
  
Related genetic diseases (OMIM): 601705 - T-cell immunodeficiency, congenital alopecia, and nail dystrophy, 601705

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 foxn1ENSDARG00000011879Danio rerio
 FOXN1ENSGALG00000043868Gallus gallus
 Foxn1ENSMUSG00000002057Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOXN4 / Q96NZ1 / forkhead box N4ENSG0000013944529
FOXJ3 / Q9UPW0 / forkhead box J3ENSG0000019881515
FOXN3 / O00409 / forkhead box N3ENSG0000005325415
FOXJ2 / Q9P0K8 / forkhead box J2ENSG0000006597015
FOXK1 / P85037 / forkhead box K1ENSG0000016491614
FOXK2 / Q01167 / forkhead box K2ENSG0000014156813
FOXN2 / P32314 / forkhead box N2ENSG0000017080213
FOXJ1 / Q92949 / forkhead box J1ENSG0000012965412


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR030456  Fork head domain conserved site 2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0002260 lymphocyte homeostasis IEA
 biological_processGO:0002360 T cell lineage commitment IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006952 defense response TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008544 epidermis development TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0030858 positive regulation of epithelial cell differentiation IDA
 biological_processGO:0033081 regulation of T cell differentiation in thymus IEA
 biological_processGO:0035878 nail development IEA
 biological_processGO:0043029 T cell homeostasis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0050673 epithelial cell proliferation IEA
 biological_processGO:0051798 positive regulation of hair follicle development IEA
 biological_processGO:0097535 lymphoid lineage cell migration into thymus IEA
 biological_processGO:0097536 thymus epithelium morphogenesis IEA
 biological_processGO:1902232 regulation of positive thymic T cell selection IEA
 cellular_componentGO:0005634 nucleus TAS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
Show

 HP:0001596 Alopecia "Loss of hair from the head or body." [HPO:curators]
Show

 HP:0001803 Nail pitting 
Show

 HP:0001807 Nail ridging 
Show

 HP:0002721 Immunodeficiency 
Show

 HP:0005352 Severe t-cell immunodeficiency 
Show

 HP:0005403 Reduced number of T cells 
Show

 HP:0005597 Congenital alopecia totalis 
Show

 HP:0008165 Reduced circulating t-helper cells 
Show

 HP:0008404 Nail dystrophy, variable 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr