ENSDARG00000010591


Danio rerio

Features
Gene ID: ENSDARG00000010591
  
Biological name :foxn4
  
Synonyms : A2BGM5 / forkhead box N4 / foxn4
  
Possible biological names infered from orthology : Forkhead box protein N4 / Q8K3Q3 / Q96NZ1
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 19385503
Gene end: 19400166
  
Corresponding Affymetrix probe sets: Dr.13699.1.S1_at (Zebrafish Array)   Dr.13699.3.A1_at (Zebrafish Array)   Dr.13699.3.S1_a_at (Zebrafish Array)   NM_131099_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000130721
Ensembl peptide - ENSDARP00000020367
NCBI entrez gene - 30315     See in Manteia.
RefSeq - NM_131099
RefSeq - XM_005165100
RefSeq Peptide - NP_571174
swissprot - A2BGM5
ZFIN ID - ZDB-GENE-990415-277
Ensembl - ENSDARG00000010591
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FOXN4ENSGALG00000005062Gallus gallus
 FOXN4ENSG00000139445Homo sapiens
 Foxn4ENSMUSG00000042002Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
foxn1 / forkhead box N1 / O15353* / Q61575* / Forkhead box protein N1 *ENSDARG0000001187928
foxn3 / forkhead box N3 / O00409* / Q499D0* / Forkhead box protein N3 *ENSDARG0000001283316
ches1 / checkpoint suppressor 1ENSDARG0000004355315
foxj3 / forkhead box J3 / Q8BUR3* / Q9UPW0* / Forkhead box protein J3 *ENSDARG0000007577414
foxk2 / forkhead box K2 / Q01167*ENSDARG0000003058314
F1QDF8 / foxj1a / forkhead box J1a / FOXJ1* / Q92949* / forkhead box J1*ENSDARG0000010191914
foxn2b / forkhead box N2b / FOXN2* / P32314* / forkhead box N2* / Mus musculus forkhead box N2 (Foxn2), transcript variant 3, mRNA.*ENSDARG0000004510513
foxj2 / forkhead box J2 / Q9ES18* / Q9P0K8* / Forkhead box protein J2 *ENSDARG0000005768013
foxk1 / forkhead box K1 / P42128* / P85037* / Forkhead box protein K1 *ENSDARG0000003787213
si:ch211-262e15.1 / FOXK2* / Q01167* / Q3UCQ1* / forkhead box K2* / Forkhead box protein K2 *ENSDARG0000001160913
forkhead box N2 / FOXN2 (1 of many) / FOXN2* / P32314*ENSDARG0000005557412
si:ch211-145o7.3ENSDARG0000006154812
F1R8Z9 / foxj1b / forkhead box J1bENSDARG0000008829011


Protein motifs (from Interpro)
Interpro ID Name
 IPR001766  Fork head domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR030456  Fork head domain conserved site 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003170 heart valve development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0010842 retina layer formation ISS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035881 amacrine cell differentiation ISS
 biological_processGO:0036302 atrioventricular canal development IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0060579 ventral spinal cord interneuron fate commitment ISS
 cellular_componentGO:0005634 nucleus ISS
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000114 heart heart structure , abnormal
heart quality , abnormal
heart contractility , abnormal
heart decreased strength , abnormal
heart blood circulation disrupted , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
Show

 ZFA:0001315 atrioventricular canal atrioventricular canal decreased size , abnormal
atrioventricular canal endocardial cushion absent , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0005064 atrioventricular valve atrioventricular valve absent , abnormal
Show

 ZFA:0005065 heart valve heart valve morphology , abnormal
Show

 ZFA:0005073 atrioventricular ring atrioventricular ring morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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