ENSMUSG00000021901


Mus musculus

Features
Gene ID: ENSMUSG00000021901
  
Biological name :Bap1
  
Synonyms : Bap1 / Q99PU7 / Ubiquitin carboxyl-terminal hydrolase BAP1
  
Possible biological names infered from orthology : BRCA1 associated protein 1 / Q92560
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 31251450
Gene end: 31259944
  
Corresponding Affymetrix probe sets: 10413752 (MoGene1.0st)   1426354_at (Mouse Genome 430 2.0 Array)   1452039_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022458
Ensembl peptide - ENSMUSP00000139903
Ensembl peptide - ENSMUSP00000139824
NCBI entrez gene - 104416     See in Manteia.
MGI - MGI:1206586
RefSeq - NM_027088
RefSeq Peptide - NP_081364
swissprot - A0A087WPT1
swissprot - A0A087WPL4
swissprot - Q99PU7
Ensembl - ENSMUSG00000021901
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bap1ENSDARG00000063051Danio rerio
 BAP1ENSGALG00000004366Gallus gallus
 BAP1ENSG00000163930Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Uchl5 / Q9WUP7 / ubiquitin carboxyl-terminal esterase L5 / Q9Y5K5* / ubiquitin C-terminal hydrolase L5*ENSMUSG0000001818916


Protein motifs (from Interpro)
Interpro ID Name
 IPR001578  Peptidase C12, ubiquitin carboxyl-terminal hydrolase
 IPR036959  Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0010035 response to inorganic substance IMP
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0035520 monoubiquitinated protein deubiquitination IEA
 biological_processGO:0035522 monoubiquitinated histone H2A deubiquitination IEA
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0061519 macrophage homeostasis IMP
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 biological_processGO:1900015 regulation of cytokine production involved in inflammatory response IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035517 PR-DUB complex IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity ISO


Pathways (from Reactome)
Pathway description
UCH proteinases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Bap1tm1a(EUCOMM)Hmgu/Bap1+
Genetic Background: C57BL/6N-Bap1tm1a(EUCOMM)Hmgu/Wtsi

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Fbn1tm1.1Itl/Fbn1tm3Rmz,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Bap1em2Test/Bap1+
Genetic Background: involves: FVB

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002641 anisopoikilocytosis "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bap1tm1a(EUCOMM)Hmgu/Bap1+
Genetic Background: C57BL/6N-Bap1tm1a(EUCOMM)Hmgu/Wtsi

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fbn1tm1.1Itl/Fbn1tm3Rmz,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Bap1em2Test/Bap1+
Genetic Background: involves: FVB

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Bap1em2Test/Bap1+
Genetic Background: involves: FVB

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Bap1em2Test/Bap1+
Genetic Background: involves: FVB

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Bap1em2Test/Bap1+
Genetic Background: involves: FVB

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0010309 increased mesothelioma incidence "greater than the expected number of neoplasms derived from the lining cells of the pleura and peritoneum, in a specific population in a given time period; is composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Bap1em2Test/Bap1+
Genetic Background: involves: FVB

 MP:0010348 increased pancreatic islet cell carcinoma incidence "greater than the expected number of malignant neoplasms arising in the pancreatic islet cells, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bap1em2Test/Bap1+
Genetic Background: involves: FVB

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0010632 cardiac muscle necrosis "pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Bap1tm1a(EUCOMM)Hmgu/Bap1+
Genetic Background: C57BL/6N-Bap1tm1a(EUCOMM)Hmgu/Wtsi

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Fbn1tm1.1Itl/Fbn1tm3Rmz,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0012167 abnormal epigenetic regulation of gene expression "any anomaly in the process that modulates the frequency, rate or extent of gene expression, in which the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence" [GO:0040029]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0012411 increased granulosa cell tumor incidence "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Bap1em2Test/Bap1+
Genetic Background: involves: FVB

Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Bap1em3Test/Bap1+
Genetic Background: involves: FVB

 MP:0012436 increased colon tumor incidence "greater than the expected number of neoplasms in the colon, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith]
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Allelic Composition: Lmf1Gt(OST195742)Lex/Lmf1Gt(OST195742)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0012768 decreased KLRG1-positive NK cell number "decrease in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation" [MGI:Annie_Speak, PMID:19479342]
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Allelic Composition: Bap1tm1a(EUCOMM)Hmgu/Bap1+
Genetic Background: C57BL/6N-Bap1tm1a(EUCOMM)Hmgu/Wtsi

 MP:0020409 abnormal cardiac thrombosis "any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0030025 giant platelets "presence of abnormally enlarged platelets that are as large as or larger than the red blood cells in the microscopic field; giant platelets may be seen in myeloproliferative and myelodysplastic conditions, autoimmune thrombocytopenia, in association with severe leukemoid reactions, and in rare inherited conditions such as Bernard-Soulier syndrome" [HP:0001902, https://www.labce.com/spg498392_giant_platelets.aspx]
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Allelic Composition: Bap1tm1.1Geno/Bap1tm1.1Geno,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034160 Ogt / Q8CGY8 / UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit / O15294* / O-linked N-acetylglucosamine (GlcNAc) transferase*  / reaction / complex
 ENSMUSG00000039275 Foxk2 / Q3UCQ1 / Forkhead box protein K2 / Q01167* / forkhead box K2*  / complex / reaction
 ENSMUSG00000056493 Foxk1 / P42128 / Forkhead box protein K1 / P85037* / forkhead box K1*  / reaction / complex
 ENSMUSG00000021264 Yy1 / Q00899 / YY1 transcription factor / P25490*  / reaction / complex
 ENSMUSG00000042548 Asxl1 / P59598 / Putative Polycomb group protein ASXL1 / Q8IXJ9* / additional sex combs like 1, transcriptional regulator*  / complex / reaction
 ENSMUSG00000031386 Hcfc1 / Q61191 / Host cell factor 1 HCF N-terminal chain 1 HCF N-terminal chain 2 HCF N-terminal chain 3 HCF N-terminal chain 4 HCF N-terminal chain 5 HCF N-terminal chain 6 HCF C-terminal c...  / reaction / complex
 ENSMUSG00000026196 Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*  / reaction / complex






 

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