ENSMUSG00000018189


Mus musculus

Features
Gene ID: ENSMUSG00000018189
  
Biological name :Uchl5
  
Synonyms : Q9WUP7 / ubiquitin carboxyl-terminal esterase L5 / Uchl5
  
Possible biological names infered from orthology : Q9Y5K5 / ubiquitin C-terminal hydrolase L5
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: F
Gene start: 143777272
Gene end: 143807466
  
Corresponding Affymetrix probe sets: 10350489 (MoGene1.0st)   1419452_at (Mouse Genome 430 2.0 Array)   1419453_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140106
Ensembl peptide - ENSMUSP00000140681
Ensembl peptide - ENSMUSP00000018333
Ensembl peptide - ENSMUSP00000139668
NCBI entrez gene - 56207     See in Manteia.
MGI - MGI:1914848
RefSeq - NM_019562
RefSeq - XM_006529760
RefSeq - NM_001159866
RefSeq Peptide - NP_001153338
RefSeq Peptide - NP_062508
swissprot - A0A087WP81
swissprot - Q9WUP7
swissprot - A0A087WRL3
Ensembl - ENSMUSG00000018189
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uchl5ENSDARG00000103404Danio rerio
 UCHL5ENSGALG00000002524Gallus gallus
 UCHL5ENSG00000116750Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bap1 / Q99PU7 / Ubiquitin carboxyl-terminal hydrolase BAP1 / Q92560* / BRCA1 associated protein 1*ENSMUSG0000002190135


Protein motifs (from Interpro)
Interpro ID Name
 IPR001578  Peptidase C12, ubiquitin carboxyl-terminal hydrolase
 IPR017390  Ubiquitinyl hydrolase, UCH37 type
 IPR033837  Ubiquitinyl hydrolase-L5
 IPR036959  Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0021670 lateral ventricle development IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0048853 forebrain morphogenesis IMP
 biological_processGO:0061136 regulation of proteasomal protein catabolic process ISO
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031011 Ino80 complex IEA
 cellular_componentGO:0031597 cytosolic proteasome complex IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0070628 proteasome binding IEA


Pathways (from Reactome)
Pathway description
UCH proteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0000826 abnormal third ventricle morphology "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0000828 abnormal fourth ventricle morphology "malformed or absent irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039041 Adrm1 / Q9JKV1 / Proteasomal ubiquitin receptor ADRM1 / Q16186* / adhesion regulating molecule 1*  / complex / reaction
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr