ENSDARG00000103404


Danio rerio

Features
Gene ID: ENSDARG00000103404
  
Biological name :uchl5
  
Synonyms : ubiquitin carboxyl-terminal hydrolase L5 / uchl5
  
Possible biological names infered from orthology : Q9WUP7 / Q9Y5K5 / ubiquitin carboxyl-terminal esterase L5 / ubiquitin C-terminal hydrolase L5
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 24220937
Gene end: 24233856
  
Corresponding Affymetrix probe sets: Dr.26391.1.A1_at (Zebrafish Array)   Dr.26391.2.S1_at (Zebrafish Array)   NM_213084_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000141540
NCBI entrez gene - 406357     See in Manteia.
RefSeq - NM_213084
RefSeq Peptide - NP_998249
swissprot - Q6NWL6
ZFIN ID - ZDB-GENE-040426-2051
Ensembl - ENSDARG00000103404
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UCHL5ENSGALG00000002524Gallus gallus
 UCHL5ENSG00000116750Homo sapiens
 Uchl5ENSMUSG00000018189Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
bap1 / BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) / Q92560* / Q99PU7* / BRCA1 associated protein 1* / Ubiquitin carboxyl-terminal hydrolase BAP1 *ENSDARG0000006305134


Protein motifs (from Interpro)
Interpro ID Name
 IPR001578  Peptidase C12, ubiquitin carboxyl-terminal hydrolase
 IPR017390  Ubiquitinyl hydrolase, UCH37 type
 IPR033837  Ubiquitinyl hydrolase-L5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:1904888 cranial skeletal system development IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0031011 Ino80 complex IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0070628 proteasome binding IEA


Pathways (from Reactome)
Pathway description
UCH proteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000106 extension extension decreased thickness , abnormal
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 ZFA:0000155 somite somite fused with somite , abnormal
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 ZFA:0001114 head head malformed , abnormal
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 ZFA:0001117 post-vent region post-vent region curled , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage morphology , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton increased thickness , abnormal
mandibular arch skeleton decreased size , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000058560 adrm1 / Q6NZ09 / adhesion regulating molecule 1 / Q9JKV1* / Gm9774* / Q16186* / Proteasomal ubiquitin receptor ADRM1 *  / reaction / complex






 

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