ENSG00000116750


Homo sapiens

Features
Gene ID: ENSG00000116750
  
Biological name :UCHL5
  
Synonyms : Q9Y5K5 / ubiquitin C-terminal hydrolase L5 / UCHL5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q31.2
Gene start: 193012250
Gene end: 193060080
  
Corresponding Affymetrix probe sets: 1570145_at (Human Genome U133 Plus 2.0 Array)   219960_s_at (Human Genome U133 Plus 2.0 Array)   220083_x_at (Human Genome U133 Plus 2.0 Array)   229248_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000412265
Ensembl peptide - ENSP00000402847
Ensembl peptide - ENSP00000408720
Ensembl peptide - ENSP00000356418
Ensembl peptide - ENSP00000356419
Ensembl peptide - ENSP00000356420
Ensembl peptide - ENSP00000356421
Ensembl peptide - ENSP00000356424
Ensembl peptide - ENSP00000356425
Ensembl peptide - ENSP00000389563
Ensembl peptide - ENSP00000391153
Ensembl peptide - ENSP00000392416
NCBI entrez gene - 51377     See in Manteia.
OMIM - 610667
RefSeq - XM_017001444
RefSeq - XM_006711370
RefSeq - XM_006711371
RefSeq - XM_011509604
RefSeq - XM_011509607
RefSeq - XM_011509608
RefSeq - XM_011509609
RefSeq - XM_017001429
RefSeq - XM_017001430
RefSeq - XM_017001431
RefSeq - XM_017001432
RefSeq - XM_017001433
RefSeq - XM_017001434
RefSeq - XM_017001435
RefSeq - XM_017001436
RefSeq - XM_017001437
RefSeq - XM_017001438
RefSeq - XM_017001439
RefSeq - XM_017001440
RefSeq - XM_017001441
RefSeq - XM_017001442
RefSeq - XM_017001443
RefSeq - NM_001199261
RefSeq - NM_001199262
RefSeq - NM_001199263
RefSeq - NM_001350844
RefSeq - NM_001350846
RefSeq - NM_001350847
RefSeq - NM_001350848
RefSeq - NM_001350849
RefSeq - NM_001350850
RefSeq - NM_001350851
RefSeq - NM_015984
RefSeq - XM_005245244
RefSeq - XM_005245246
RefSeq - XM_005245247
RefSeq - XM_005245248
RefSeq - XM_005245249
RefSeq - XM_006711366
RefSeq - XM_006711367
RefSeq - XM_006711368
RefSeq - XM_006711369
RefSeq Peptide - NP_057068
RefSeq Peptide - NP_001337777
RefSeq Peptide - NP_001186190
RefSeq Peptide - NP_001186191
RefSeq Peptide - NP_001186192
RefSeq Peptide - NP_001337771
RefSeq Peptide - NP_001337773
RefSeq Peptide - NP_001337775
RefSeq Peptide - NP_001337776
RefSeq Peptide - NP_001337778
RefSeq Peptide - NP_001337779
RefSeq Peptide - NP_001337780
swissprot - Q5LJB0
swissprot - H0Y636
swissprot - H0Y6Y4
swissprot - Q5LJA5
swissprot - Q5LJA9
swissprot - H0Y4K0
swissprot - Q5LJB1
swissprot - Q9Y5K5
swissprot - H0Y4E0
Ensembl - ENSG00000116750
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uchl5ENSDARG00000103404Danio rerio
 UCHL5ENSGALG00000002524Gallus gallus
 Uchl5ENSMUSG00000018189Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BAP1 / Q92560 / BRCA1 associated protein 1ENSG0000016393035


Protein motifs (from Interpro)
Interpro ID Name
 IPR001578  Peptidase C12, ubiquitin carboxyl-terminal hydrolase
 IPR017390  Ubiquitinyl hydrolase, UCH37 type
 IPR033837  Ubiquitinyl hydrolase-L5
 IPR036959  Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0021670 lateral ventricle development IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0048853 forebrain morphogenesis IEA
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IMP
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031011 Ino80 complex IDA
 cellular_componentGO:0031597 cytosolic proteasome complex IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0070628 proteasome binding IDA


Pathways (from Reactome)
Pathway description
Downregulation of TGF-beta receptor signaling
UCH proteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130706 ADRM1 / Q16186 / adhesion regulating molecule 1  / complex / reaction
 ENSG00000106799 P36897 / TGFBR1 / transforming growth factor beta receptor 1  / reaction / complex
 ENSG00000163513 P37173 / TGFBR2 / transforming growth factor beta receptor 2  / reaction / complex
 ENSG00000105329 TGFB1 / P01137 / transforming growth factor beta 1  / reaction / complex
 ENSG00000101665 SMAD7 / O15105 / SMAD family member 7  / complex / reaction






 

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