ENSMUSG00000039041


Mus musculus

Features
Gene ID: ENSMUSG00000039041
  
Biological name :Adrm1
  
Synonyms : Adrm1 / Proteasomal ubiquitin receptor ADRM1 / Q9JKV1
  
Possible biological names infered from orthology : adhesion regulating molecule 1 / Q16186
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H4
Gene start: 180171485
Gene end: 180176286
  
Corresponding Affymetrix probe sets: 10479351 (MoGene1.0st)   10499883 (MoGene1.0st)   1419263_a_at (Mouse Genome 430 2.0 Array)   1438170_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050076
NCBI entrez gene - 56436     See in Manteia.
MGI - MGI:1929289
RefSeq - NM_019822
RefSeq - XM_006500680
RefSeq Peptide - NP_062796
swissprot - Q9JKV1
Ensembl - ENSMUSG00000039041
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adrm1ENSDARG00000058560Danio rerio
 ADRM1ENSGALG00000005200Gallus gallus
 ADRM1ENSG00000130706Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm9774 / ADRM1* / Q16186* / adhesion regulating molecule 1*ENSMUSG0000004216599


Protein motifs (from Interpro)
Interpro ID Name
 IPR006773  Proteasomal ubiquitin receptor Rpn13/ADRM1
 IPR032368  UCH-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter ISO
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0010950 positive regulation of endopeptidase activity IEA
 biological_processGO:0033081 regulation of T cell differentiation in thymus IMP
 biological_processGO:0042699 follicle-stimulating hormone signaling pathway IMP
 biological_processGO:0043248 proteasome assembly ISO
 biological_processGO:0048477 oogenesis IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0060009 Sertoli cell development IMP
 biological_processGO:0060399 positive regulation of growth hormone receptor signaling pathway IMP
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0072520 seminiferous tubule development IMP
 cellular_componentGO:0000502 proteasome complex ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0008541 proteasome regulatory particle, lid subcomplex IBA
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043130 ubiquitin binding IBA
 molecular_functionGO:0061133 endopeptidase activator activity ISO
 molecular_functionGO:0070628 proteasome binding ISO


Pathways (from Reactome)
Pathway description
UCH proteinases
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0005123 increased circulating growth hormone level "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0008081 abnormal single-positive T cell number "anomaly in the number of T cells bearing either CD4-positive or CD8-positive markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0009361 abnormal primordial ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0009444 ovarian follicular cyst "a sac filled with fluid that may develop when the structure containing the egg fails to break open at the time of ovulation" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lpar4tm1Sati/Lpar4tm1Sati
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018189 Uchl5 / Q9WUP7 / ubiquitin carboxyl-terminal esterase L5 / Q9Y5K5* / ubiquitin C-terminal hydrolase L5*  / complex / reaction
 ENSMUSG00000047879 Usp14 / Q9JMA1 / ubiquitin specific peptidase 14 / P54578*  / reaction / complex






 

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