ENSMUSG00000020246


Mus musculus

Features
Gene ID: ENSMUSG00000020246
  
Biological name :Hcfc2
  
Synonyms : Hcfc2 / host cell factor C2
  
Possible biological names infered from orthology : Q9Y5Z7
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 82696160
Gene end: 82742428
  
Corresponding Affymetrix probe sets: 10365242 (MoGene1.0st)   1428617_at (Mouse Genome 430 2.0 Array)   1428618_at (Mouse Genome 430 2.0 Array)   1438328_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020478
Ensembl peptide - ENSMUSP00000124472
Ensembl peptide - ENSMUSP00000124489
NCBI entrez gene - 67933     See in Manteia.
MGI - MGI:1915183
RefSeq - XM_011243545
RefSeq - XM_006514010
RefSeq - XM_006514011
RefSeq - XM_006514013
RefSeq - XM_011243544
RefSeq - NM_001081218
RefSeq Peptide - NP_001074687
swissprot - G5E837
swissprot - F6T088
swissprot - F6T0G2
Ensembl - ENSMUSG00000020246
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hcfc2ENSDARG00000058127Danio rerio
 HCFC2ENSGALG00000029616Gallus gallus
 HCFC2ENSG00000111727Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hcfc1 / Q61191 / Host cell factor 1 HCF N-terminal chain 1 HCF N-terminal chain 2 HCF N-terminal chain 3 HCF N-terminal chain 4 HCF N-terminal chain 5 HCF N-terminal chain 6 HCF C-terminal c...ENSMUSG0000003138657
Lztr1 / Q9CQ33 / Mus musculus leucine-zipper-like transcriptional regulator, 1 (Lztr1), transcript variant 2, mRNA. / Q8N653* / leucine zipper like transcription regulator 1*ENSMUSG0000002276115
Klhdc3 / kelch domain containing 3 / Q9BQ90*ENSMUSG0000006357613
Q8VCH5 / Rabepk / Rab9 effector protein with kelch motifs / Q7Z6M1*ENSMUSG0000007095313
Klhdc1 / Q80YG3 / Kelch domain-containing protein 1 / Q8N7A1* / kelch domain containing 1*ENSMUSG0000005189013
Klhdc2 / Q4G5Y1 / Kelch domain-containing protein 2 / Q9Y2U9* / kelch domain containing 2*ENSMUSG0000002097812
Q6PAR0 / Klhdc10 / Kelch domain-containing protein 10 / Q6PID8* / kelch domain containing 10*ENSMUSG0000002977511


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR006652  Kelch repeat type 1
 IPR013783  Immunoglobulin-like fold
 IPR015915  Kelch-type beta propeller
 IPR036116  Fibronectin type III superfamily
 IPR037293  Galactose oxidase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0048188 Set1C/COMPASS complex IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arl8btm1Kkon/Arl8btm1Kkon,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur
Genetic Background: B6.129P2-Cftrtm1Eur

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Arl8btm1Kkon/Arl8btm1Kkon,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

Allelic Composition: Hcfc2fkls/Hcfc2fkls
Genetic Background: involves: C57BL/6J

Allelic Composition: Hcfc2fkls/Hcfc2min
Genetic Background: involves: C57BL/6J

Allelic Composition: Hcfc2fkls/Hcfc2sca
Genetic Background: involves: C57BL/6J

Allelic Composition: Hcfc2em1Btlr/Hcfc2em1Btlr
Genetic Background: C57BL/6J-Hcfc2em1Btlr

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Arl8btm1Kkon/Arl8btm1Kkon,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

Allelic Composition: Hcfc2fkls/Hcfc2fkls
Genetic Background: involves: C57BL/6J

 MP:0008574 decreased circulating interferon-alpha level "reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Hcfc2fkls/Hcfc2fkls
Genetic Background: involves: C57BL/6J

 MP:0008576 decreased circulating interferon-beta level "reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Hcfc2fkls/Hcfc2fkls
Genetic Background: involves: C57BL/6J

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hcfc2fkls/Hcfc2fkls
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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