ENSMUSG00000037486


Mus musculus

Features
Gene ID: ENSMUSG00000037486
  
Biological name :Asxl2
  
Synonyms : Asxl2 / putative Polycomb group protein ASXL2 isoform 1
  
Possible biological names infered from orthology : additional sex combs like 2, transcriptional regulator / Q76L83
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 3426857
Gene end: 3506852
  
Corresponding Affymetrix probe sets: 10394173 (MoGene1.0st)   1439063_at (Mouse Genome 430 2.0 Array)   1444754_at (Mouse Genome 430 2.0 Array)   1453295_at (Mouse Genome 430 2.0 Array)   1458366_at (Mouse Genome 430 2.0 Array)   1460597_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133639
Ensembl peptide - ENSMUSP00000106846
Ensembl peptide - ENSMUSP00000116048
Ensembl peptide - ENSMUSP00000117384
Ensembl peptide - ENSMUSP00000089629
NCBI entrez gene - 75302     See in Manteia.
MGI - MGI:1922552
RefSeq - XM_017315230
RefSeq - NM_001270988
RefSeq - NM_172421
RefSeq - XM_006515239
RefSeq - XM_006515241
RefSeq - XM_017315229
RefSeq Peptide - NP_001257917
RefSeq Peptide - NP_766009
swissprot - D3Z112
swissprot - G3UXC9
swissprot - D6REV1
swissprot - F6WV21
swissprot - D6RI62
Ensembl - ENSMUSG00000037486
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 asxl2ENSDARG00000076501Danio rerio
 ASXL2ENSGALG00000016531Gallus gallus
 ASXL2ENSG00000143970Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Asxl1 / P59598 / Putative Polycomb group protein ASXL1 / Q8IXJ9* / additional sex combs like 1, transcriptional regulator*ENSMUSG0000004254829
Asxl3 / Q8C4A5 / Putative Polycomb group protein ASXL3 / Q9C0F0* / additional sex combs like 3, transcriptional regulator*ENSMUSG0000004521528


Protein motifs (from Interpro)
Interpro ID Name
 IPR007759  HB1/Asxl, restriction endonuclease HTH domain
 IPR024811  Polycomb protein ASX/ASX-like
 IPR024817  ASX-like protein 2
 IPR026905  Protein ASX-like, PHD domain
 IPR028020  ASX homology domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
UCH proteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0004617 sacral vertebral transformation "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0004687 split vertebrae "any vertebrae or vertebral section that is cleft into two parts " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * SKH1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr