ENSMUSG00000051176


Mus musculus

Features
Gene ID: ENSMUSG00000051176
  
Biological name :Zfp42
  
Synonyms : Zfp42 / zinc finger protein 42
  
Possible biological names infered from orthology : Q96MM3 / ZFP42 zinc finger protein
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A4
Gene start: 43295063
Gene end: 43306980
  
Corresponding Affymetrix probe sets: 10578401 (MoGene1.0st)   1418362_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147607
Ensembl peptide - ENSMUSP00000080765
Ensembl peptide - ENSMUSP00000147606
NCBI entrez gene - 22702     See in Manteia.
MGI - MGI:99187
RefSeq - NM_009556
RefSeq - XM_006509316
RefSeq - XM_011242186
RefSeq Peptide - NP_033582
swissprot - E9QK22
Ensembl - ENSMUSG00000051176
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 yy1aENSDARG00000042796Danio rerio
 yy1bENSDARG00000027978Danio rerio
 ZFP42ENSG00000179059Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Yy1 / Q00899 / YY1 transcription factor / P25490*ENSMUSG0000002126438
Yy2 / Q3TTC2 / Yy2 transcription factor / O15391*ENSMUSG0000009173635
Mtf1 / Q07243 / Metal regulatory transcription factor 1 / Q14872*ENSMUSG0000002889023
Q8BMU0 / Zfp523 / zinc finger protein 523 / ZNF76* / P36508* / zinc finger protein 76*ENSMUSG0000002422020
Zxdc / Q8C8V1 / ZXD family zinc finger C / Q2QGD7*ENSMUSG0000003443018
O70230 / Zfp143 / zinc finger protein 143 / P52747* / ZNF143*ENSMUSG0000006107918
Zxdb / A2CE44 / zinc finger, X-linked, duplicated B / ZXDA* / P98169* / P98168* / zinc finger, X-linked, duplicated A*ENSMUSG0000007306217
Gtf3a / transcription factor IIIA / Q92664* / general transcription factor IIIA*ENSMUSG0000001650316
Q8BKX7 / Zfp410 / zinc finger protein 410 / Q86VK4* / ZNF410*ENSMUSG0000004247216


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0008585 female gonad development IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aicdatm2.1Hon/Aicdatm2.1Hon
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp63tm1Fmc/Trp63+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp63tm1Fmc/Trp63+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003787 abnormal imprinting "defect in the normal inactivation of specific loci during gametogenesis" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Aicdatm2.1Hon/Aicdatm2.1Hon
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp63tm1Fmc/Trp63+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Thap11tm1.1Tpz/Thap11tm1.1Tpz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Zfp42tm1Hini/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
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Allelic Composition: Aicdatm2.1Hon/Aicdatm2.1Hon
Genetic Background: involves: BALB/c * C57BL/6

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp63tm1Fmc/Trp63+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp63tm1Fmc/Trp63+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Aicdatm2.1Hon/Aicdatm2.1Hon
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Zfp42Gt(XB238)Byg/Zfp42+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Aicdatm2.1Hon/Aicdatm2.1Hon
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
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Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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