ENSMUSG00000002028


Mus musculus

Features
Gene ID: ENSMUSG00000002028
  
Biological name :Kmt2a
  
Synonyms : Kmt2a / Mus musculus lysine (K)-specific methyltransferase 2A (Kmt2a), transcript variant 1, mRNA. / P55200
  
Possible biological names infered from orthology : lysine methyltransferase 2A / Q03164
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.2
Gene start: 44803355
Gene end: 44881296
  
Corresponding Affymetrix probe sets: 10592942 (MoGene1.0st)   1427283_at (Mouse Genome 430 2.0 Array)   1452377_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138767
Ensembl peptide - ENSMUSP00000138138
Ensembl peptide - ENSMUSP00000149173
Ensembl peptide - ENSMUSP00000002095
Ensembl peptide - ENSMUSP00000110337
Ensembl peptide - ENSMUSP00000122541
NCBI entrez gene - 214162     See in Manteia.
MGI - MGI:96995
RefSeq - XM_011242444
RefSeq - NM_001081049
RefSeq - NM_001357549
RefSeq - XM_006510128
RefSeq - XM_011242441
RefSeq - XM_011242442
RefSeq - XM_011242443
RefSeq Peptide - NP_001344478
RefSeq Peptide - NP_001074518
swissprot - S4R2S5
swissprot - S4R199
swissprot - P55200
swissprot - A0A1L1SQS9
swissprot - D3Z5H5
Ensembl - ENSMUSG00000002028
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kmt2aENSDARG00000004537Danio rerio
 ENSGALG00000006818Gallus gallus
 KMT2AENSG00000118058Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kmt2b / O08550 / Histone-lysine N-methyltransferase 2B / Q9UMN6* / lysine methyltransferase 2B*ENSMUSG0000000630727
Kmt2d / Q6PDK2 / Histone-lysine N-methyltransferase 2D / O14686* / lysine methyltransferase 2D*ENSMUSG0000004815415
Kmt2c / lysine methyltransferase 2C / Q8NEZ4*ENSMUSG0000003805615
Q8CFT2 / Setd1b / Histone-lysine N-methyltransferase SETD1B / Q9UPS6* / SET domain containing 1B*ENSMUSG000000383847
Setd1a / SET domain containing 1A / O15047*ENSMUSG000000423087
AC149222.1 / O15047* / SETD1A* / SET domain containing 1A*ENSMUSG000001088155


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR001487  Bromodomain
 IPR001965  Zinc finger, PHD-type
 IPR002857  Zinc finger, CXXC-type
 IPR003616  Post-SET domain
 IPR003888  FY-rich, N-terminal
 IPR003889  FY-rich, C-terminal
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR016569  Methyltransferase, trithorax
 IPR019787  Zinc finger, PHD-finger
 IPR034732  Extended PHD (ePHD) domain
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006306 DNA methylation IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0009416 response to light stimulus IMP
 biological_processGO:0009791 post-embryonic development IGI
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0018026 peptidyl-lysine monomethylation IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0032411 positive regulation of transporter activity IEA
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0035640 exploration behavior IMP
 biological_processGO:0035864 response to potassium ion IEA
 biological_processGO:0043984 histone H4-K16 acetylation IEA
 biological_processGO:0044648 histone H3-K4 dimethylation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048536 spleen development IGI
 biological_processGO:0048873 homeostasis of number of cells within a tissue IGI
 biological_processGO:0050890 cognition IMP
 biological_processGO:0051568 histone H3-K4 methylation ISS
 biological_processGO:0051569 regulation of histone H3-K4 methylation IMP
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation IMP
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0071440 regulation of histone H3-K14 acetylation IMP
 biological_processGO:0080182 histone H3-K4 trimethylation IEA
 biological_processGO:1901674 regulation of histone H3-K27 acetylation IMP
 biological_processGO:1905642 negative regulation of DNA methylation IEA
 biological_processGO:2000615 regulation of histone H3-K9 acetylation IMP
 biological_processGO:2001040 positive regulation of cellular response to drug IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0035097 histone methyltransferase complex ISS
 cellular_componentGO:0071339 MLL1 complex IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0045322 unmethylated CpG binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070577 lysine-acetylated histone binding IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000017 big ears "outer ears of a greater than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Pou1f1dw/Pou1f1dw
Genetic Background: DW/J Pou1f1dw

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kmt2atm2Sjk/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

 MP:0000448 pointed snout "nose tapers to a small tip, sharper angle than wild type " [J:18378]
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Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trpc5tm1.1Clph/Y
Genetic Background: involves: 129S1/SvImJ

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Tfebtm1Est/Tfeb+,Tfectm1Est/Tfectm1Est
Genetic Background: either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Kdm8Gt(AZ0518)Wtsi/Kdm8Gt(AZ0518)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

Allelic Composition: Kmt2atm2Sjk/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Kmt2atm1Thr/Kmt2a+,Mllt3tm2Thr/Mllt3+,Tg(Lck-cre)1Thr/?
Genetic Background: involves: 129S/SvEv

Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh
Genetic Background: B6.129X1-Kmt2atm1.1Jjdh

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kmt2atm2Sjk/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Nit1tm1Hbn/Nit1tm1.1Hbn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kmt2atm2.1Mlc/Kmt2atm2.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kmt2atm2.1Mlc/Kmt2atm2.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
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Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kmt2atm1Thr/Kmt2a+,Mllt3tm2Thr/Mllt3+,Tg(Lck-cre)1Thr/?
Genetic Background: involves: 129S/SvEv

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Kmt2atm1Thr/Kmt2a+,Mllt3tm2Thr/Mllt3+,Tg(Lck-cre)1Thr/?
Genetic Background: involves: 129S/SvEv

Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eportm1Lizon/Eportm1Lizon
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Flt3tm1Dgg/Flt3tm1Dgg,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atf5tm1(KOMP)Vlcg/Atf5tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Kmt2atm3Mlc/Kmt2atm3Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

Allelic Composition: Kmt2atm1Thr/Kmt2a+,Mllt3tm2Thr/Mllt3+,Tg(Lck-cre)1Thr/?
Genetic Background: involves: 129S/SvEv

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

Allelic Composition: Kmt2atm1Thr/Kmt2a+,Mllt3tm2Thr/Mllt3+,Tg(Lck-cre)1Thr/?
Genetic Background: involves: 129S/SvEv

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nit1tm1Hbn/Nit1tm1.1Hbn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kmt2atm2Sjk/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

 MP:0004049 acute promyelocytic leukemia "rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0004569 glossopharyngeal nerve hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue; the branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh
Genetic Background: B6.129X1-Kmt2atm1.1Jjdh

Allelic Composition: Kmt2atm1Sjk/Kmt2atm1Sjk
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004607 abnormal cervical atlas morphology "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kmt2atm1Djab/Kmt2atm1Djab
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kmt2atm1Djab/Kmt2atm1Djab
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004617 sacral vertebral transformation "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Vss/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: Kmt2atm1.1Brad/Kmt2atm1.1Brad
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: Kmt2atm1.1Brad/Kmt2atm1.1Brad
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Kmt2atm2.1Mlc/Kmt2atm2.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2a+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nit1tm1Hbn/Nit1tm1.1Hbn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005649 spleen neoplasm "abnormal new cellular growth of the spleen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:70407]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0006099 thin granule layer "reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Clgr/Kmt2a+
Genetic Background: B6.129-Kmt2atm1Clgr

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1.1Brad/Kmt2atm1.1Brad
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm2Sjk/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Kmt2atm1.1Brad/Kmt2atm1.1Brad
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kmt2atm1Brad/Kmt2atm1Brad,Commd10Tg(Vav1-icre)A2Kio/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca

Allelic Composition: Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Brad/Kmt2atm1Brad,Commd10Tg(Vav1-icre)A2Kio/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

 MP:0009879 abnormal arcus anterior morphology "any structural anomaly in the arch that connects the lateral masses of the atlas anteriorly and articulates with the anterior articular facet of the dens of the axis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1Djab/Kmt2atm1Djab
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh
Genetic Background: B6.129X1-Kmt2atm1.1Jjdh

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0010082 sternebra fusion "appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh
Genetic Background: B6.129X1-Kmt2atm1.1Jjdh

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

 MP:0010296 increased hemolymphoid system tumor incidence "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Kmt2atm1Thr/Kmt2a+,Mllt3tm2Thr/Mllt3+,Tg(Lck-cre)1Thr/?
Genetic Background: involves: 129S/SvEv

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm2Sjk/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Polhtm2Fmh/Polhtm2Fmh,Polid/Poli+
Genetic Background: B6.129-Polhtm2Fmh Polid

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pcdh15m1Btlr/Pcdh15m1Btlr
Genetic Background: C57BL/6J-Pcdh15m1Btlr

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kmt2atm2.1Mlc/Kmt2atm2.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Kmt2atm1.1Erns/Kmt2atm1.1Erns
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Kmt2atm1Sjk/Kmt2atm1.2Erns
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

Allelic Composition: Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Kmt2atm1.1Brad/Kmt2atm1.1Brad
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Flt3tm1Dgg/Flt3+,Kmt2atm1Clgr/Kmt2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Btkm2Anu/Btkm2Anu
Genetic Background: C57BL/6NCrlAnu-Btkm2Anu

Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0011808 abnormal myoblast differentiation "anomaly in the process in which a relatively unspecialized cell acquires specialized features of a myoblast, a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers" [GO:0045445]
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Allelic Composition: Kmt2atm1Sjk/Kmt2atm1Sjk
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0012284 increased sternebra number "increased average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:anna]
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Allelic Composition: Kmt2atm1Djab/Kmt2atm1Djab
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0013176 abnormal tail position or orientation " tail is displaced from the normal location and/or does not orient in a typical pattern" [MGI:anna]
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Allelic Composition: Kmt2atm1(AFF1)Ksy/Kmt2a+
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

 MP:0030066 short face "an abnormally decreased height (length) of the face" [MGI:anna]
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Allelic Composition: Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / complex / reaction






 

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