ENSMUSG00000042308


Mus musculus

Features
Gene ID: ENSMUSG00000042308
  
Biological name :Setd1a
  
Synonyms : Setd1a / SET domain containing 1A
  
Possible biological names infered from orthology : O15047
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 127776670
Gene end: 127800122
  
Corresponding Affymetrix probe sets: 10557758 (MoGene1.0st)   1427116_at (Mouse Genome 430 2.0 Array)   1450336_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037600
Ensembl peptide - ENSMUSP00000120666
Ensembl peptide - ENSMUSP00000115994
Ensembl peptide - ENSMUSP00000115248
Ensembl peptide - ENSMUSP00000047672
NCBI entrez gene - 233904     See in Manteia.
MGI - MGI:2446244
RefSeq - XM_017322214
RefSeq - NM_178029
RefSeq - XM_017322211
RefSeq - XM_017322212
RefSeq - XM_017322213
RefSeq Peptide - NP_821172
swissprot - D3YX07
swissprot - D3YUD4
swissprot - D3YXL2
swissprot - E9PYH6
Ensembl - ENSMUSG00000042308
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 setd1aENSDARG00000060030Danio rerio
 O15047ENSG00000099381Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC149222.1 / O15047* / SETD1A* / SET domain containing 1A*ENSMUSG0000010881568
Q8CFT2 / Setd1b / Histone-lysine N-methyltransferase SETD1B / Q9UPS6* / SET domain containing 1B*ENSMUSG0000003838442
Kmt2c / lysine methyltransferase 2C / Q8NEZ4*ENSMUSG0000003805618
Kmt2d / Q6PDK2 / Histone-lysine N-methyltransferase 2D / O14686* / lysine methyltransferase 2D*ENSMUSG0000004815417
Kmt2a / P55200 / Mus musculus lysine (K)-specific methyltransferase 2A (Kmt2a), transcript variant 1, mRNA. / Q03164* / lysine methyltransferase 2A*ENSMUSG0000000202816
Kmt2b / O08550 / Histone-lysine N-methyltransferase 2B / Q9UMN6* / lysine methyltransferase 2B*ENSMUSG0000000630713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR001214  SET domain
 IPR003616  Post-SET domain
 IPR024657  COMPASS complex Set1 subunit, N-SET domain
 IPR034467  Set1A, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0045646 regulation of erythrocyte differentiation IMP
 biological_processGO:0048096 chromatin-mediated maintenance of transcription NAS
 biological_processGO:0051568 histone H3-K4 methylation NAS
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation ISO
 biological_processGO:1902275 regulation of chromatin organization IDA
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IMP
 biological_processGO:2000648 positive regulation of stem cell proliferation IMP
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0035097 histone methyltransferase complex TAS
 cellular_componentGO:0048188 Set1C/COMPASS complex TAS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding ISO
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) NAS
 molecular_functionGO:1990188 euchromatin binding IDA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Pip4k2atm1.2Lca/Pip4k2atm1.2Lca,Pip4k2bGt(Betageo)1Lca/Pip4k2b+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * 129S5/SvEvBrd

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Pip4k2atm1.2Lca/Pip4k2atm1.2Lca,Pip4k2bGt(Betageo)1Lca/Pip4k2b+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * 129S5/SvEvBrd

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
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Allelic Composition: Pip4k2atm1.2Lca/Pip4k2atm1.2Lca,Pip4k2bGt(Betageo)1Lca/Pip4k2b+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * 129S5/SvEvBrd

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Pip4k2atm1.2Lca/Pip4k2atm1.2Lca,Pip4k2bGt(Betageo)1Lca/Pip4k2b+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * 129S5/SvEvBrd

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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