ENSMUSG00000038384


Mus musculus

Features
Gene ID: ENSMUSG00000038384
  
Biological name :Setd1b
  
Synonyms : Histone-lysine N-methyltransferase SETD1B / Q8CFT2 / Setd1b
  
Possible biological names infered from orthology : Q9UPS6 / SET domain containing 1B
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 123142193
Gene end: 123168629
  
Corresponding Affymetrix probe sets: 10525489 (MoGene1.0st)   10525495 (MoGene1.0st)   1437353_at (Mouse Genome 430 2.0 Array)   1440836_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133933
Ensembl peptide - ENSMUSP00000134353
Ensembl peptide - ENSMUSP00000134461
Ensembl peptide - ENSMUSP00000134686
NCBI entrez gene - 208043     See in Manteia.
MGI - MGI:2652820
RefSeq - NM_001040398
RefSeq - XM_006530237
RefSeq - XM_006530238
RefSeq Peptide - NP_001035488
swissprot - G3UZ56
swissprot - Q8CFT2
Ensembl - ENSMUSG00000038384
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 setd1baENSDARG00000060847Danio rerio
 SETD1BENSGALG00000004324Gallus gallus
 Q9UPS6ENSG00000139718Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Setd1a / SET domain containing 1A / O15047*ENSMUSG0000004230836
AC149222.1 / O15047* / SETD1A* / SET domain containing 1A*ENSMUSG0000010881525
Kmt2c / lysine methyltransferase 2C / Q8NEZ4*ENSMUSG0000003805620
Kmt2d / Q6PDK2 / Histone-lysine N-methyltransferase 2D / O14686* / lysine methyltransferase 2D*ENSMUSG0000004815418
Kmt2a / P55200 / Mus musculus lysine (K)-specific methyltransferase 2A (Kmt2a), transcript variant 1, mRNA. / Q03164* / lysine methyltransferase 2A*ENSMUSG0000000202815
Kmt2b / O08550 / Histone-lysine N-methyltransferase 2B / Q9UMN6* / lysine methyltransferase 2B*ENSMUSG0000000630714


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR001214  SET domain
 IPR003616  Post-SET domain
 IPR024657  COMPASS complex Set1 subunit, N-SET domain
 IPR034468  Set1B, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0051568 histone H3-K4 methylation IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0035097 histone methyltransferase complex IEA
 cellular_componentGO:0048188 Set1C/COMPASS complex ISS
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Btrctm1Paga/Btrc+,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Btrctm1Paga/Btrc+,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Setd1btm1.3Afst/Setd1btm1.3Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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