ENSG00000139718


Homo sapiens

Features
Gene ID: ENSG00000139718
  
Biological name :SETD1B
  
Synonyms : Q9UPS6 / SETD1B / SET domain containing 1B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.31
Gene start: 121804180
Gene end: 121832584
  
Corresponding Affymetrix probe sets: 213153_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442924
Ensembl peptide - ENSP00000481531
Ensembl peptide - ENSP00000474253
Ensembl peptide - ENSP00000267197
NCBI entrez gene - 23067     See in Manteia.
OMIM - 611055
RefSeq - XM_006719296
RefSeq - XM_005253858
RefSeq - NM_015048
RefSeq Peptide - NP_055863
RefSeq Peptide - NP_001340274
swissprot - Q9UPS6
swissprot - A0A0A0MQV9
Ensembl - ENSG00000139718
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 setd1baENSDARG00000060847Danio rerio
 SETD1BENSGALG00000004324Gallus gallus
 Q8CFT2ENSMUSG00000038384Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O15047 / SETD1A / SET domain containing 1AENSG0000009938136
KMT2C / Q8NEZ4 / lysine methyltransferase 2CENSG0000005560920
KMT2D / O14686 / lysine methyltransferase 2DENSG0000016754819
KMT2A / Q03164 / lysine methyltransferase 2AENSG0000011805815
KMT2B / Q9UMN6 / lysine methyltransferase 2BENSG0000027233314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR001214  SET domain
 IPR003616  Post-SET domain
 IPR024657  COMPASS complex Set1 subunit, N-SET domain
 IPR034468  Set1B, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0051568 histone H3-K4 methylation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0035097 histone methyltransferase complex IDA
 cellular_componentGO:0048188 Set1C/COMPASS complex IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity TAS
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IDA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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