ENSG00000099381


Homo sapiens

Features
Gene ID: ENSG00000099381
  
Biological name :SETD1A
  
Synonyms : O15047 / SETD1A / SET domain containing 1A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p11.2
Gene start: 30957294
Gene end: 30984664
  
Corresponding Affymetrix probe sets: 213202_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000391408
Ensembl peptide - ENSP00000262519
NCBI entrez gene - 9739     See in Manteia.
OMIM - 611052
RefSeq - XM_017023909
RefSeq - NM_014712
RefSeq - XM_005255723
RefSeq - XM_006721106
RefSeq Peptide - NP_055527
swissprot - C9J2Z9
swissprot - O15047
Ensembl - ENSG00000099381
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 setd1aENSDARG00000060030Danio rerio
 AC149222.1ENSMUSG00000108815Mus musculus
 Setd1aENSMUSG00000042308Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UPS6 / SETD1B / SET domain containing 1BENSG0000013971842
KMT2C / Q8NEZ4 / lysine methyltransferase 2CENSG0000005560919
KMT2D / O14686 / lysine methyltransferase 2DENSG0000016754817
KMT2A / Q03164 / lysine methyltransferase 2AENSG0000011805816
KMT2B / Q9UMN6 / lysine methyltransferase 2BENSG0000027233314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR001214  SET domain
 IPR003616  Post-SET domain
 IPR024657  COMPASS complex Set1 subunit, N-SET domain
 IPR034467  Set1A, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0051568 histone H3-K4 methylation IEA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IDA
 biological_processGO:1902275 regulation of chromatin organization IDA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0035097 histone methyltransferase complex IDA
 cellular_componentGO:0048188 Set1C/COMPASS complex TAS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity TAS
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IDA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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