Manteia - Molecule gene

ENSMUSG00000006307

Mus musculus

Features

Gene ID:	ENSMUSG00000006307

Biological name :	Kmt2b

Synonyms :	Histone-lysine N-methyltransferase 2B / Kmt2b / O08550

Possible biological names infered from orthology :	lysine methyltransferase 2B / Q9UMN6

Species:	Mus musculus

Chr. number:	7
Strand:	-1
Band:	B1
Gene start:	30568858
Gene end:	30588726

Corresponding Affymetrix probe sets:	10562005 (MoGene1.0st) 1452916_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000006470 Ensembl peptide - ENSMUSP00000103789 Ensembl peptide - ENSMUSP00000118486 NCBI entrez gene - 75410 See in Manteia. MGI - MGI:109565 RefSeq - XM_011250733 RefSeq - NM_001290573 RefSeq - NM_029274 RefSeq - XM_006540408 RefSeq Peptide - NP_001277502 RefSeq Peptide - NP_083550 swissprot - F8WJ40 swissprot - O08550 swissprot - F6W623 Ensembl - ENSMUSG00000006307

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
kmt2ba	ENSDARG00000062962	Danio rerio
kmt2bb	ENSDARG00000060697	Danio rerio
KMT2B	ENSG00000272333	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kmt2a / P55200 / Mus musculus lysine (K)-specific methyltransferase 2A (Kmt2a), transcript variant 1, mRNA. / Q03164* / lysine methyltransferase 2A*	ENSMUSG00000002028	40
Kmt2c / lysine methyltransferase 2C / Q8NEZ4*	ENSMUSG00000038056	18
Kmt2d / Q6PDK2 / Histone-lysine N-methyltransferase 2D / O14686* / lysine methyltransferase 2D*	ENSMUSG00000048154	18
Q8CFT2 / Setd1b / Histone-lysine N-methyltransferase SETD1B / Q9UPS6* / SET domain containing 1B*	ENSMUSG00000038384	10
Setd1a / SET domain containing 1A / O15047*	ENSMUSG00000042308	9
AC149222.1 / O15047* / SETD1A* / SET domain containing 1A*	ENSMUSG00000108815	6

Protein motifs (from Interpro)

Interpro ID	Name
IPR001214	SET domain
IPR001965	Zinc finger, PHD-type
IPR002857	Zinc finger, CXXC-type
IPR003616	Post-SET domain
IPR003888	FY-rich, N-terminal
IPR003889	FY-rich, C-terminal
IPR011011	Zinc finger, FYVE/PHD-type
IPR011989	Armadillo-like helical
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR016569	Methyltransferase, trithorax
IPR019787	Zinc finger, PHD-finger
IPR034732	Extended PHD (ePHD) domain
IPR036427	Bromodomain-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001541	ovarian follicle development	IMP
biological_process	GO:0006325	chromatin organization	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007613	memory	IMP
biological_process	GO:0009994	oocyte differentiation	IMP
biological_process	GO:0016458	gene silencing	IMP
biological_process	GO:0030728	ovulation	IMP
biological_process	GO:0032259	methylation	IEA
biological_process	GO:0034968	histone lysine methylation	IMP
biological_process	GO:0051568	histone H3-K4 methylation	IEA
biological_process	GO:0051569	regulation of histone H3-K4 methylation	IMP
biological_process	GO:0080182	histone H3-K4 trimethylation	IMP
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0035097	histone methyltransferase complex	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0008168	methyltransferase activity	IEA
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0018024	histone-lysine N-methyltransferase activity	IEA
molecular_function	GO:0042800	histone methyltransferase activity (H3-K4 specific)	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

PKMTs methylate histone lysines

RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000269	abnormal looping morphogenesis	"atypical bending of the primitive heart tube during early development" [J:27443]	Show Allelic Composition: Kmt2b^Gena263/Kmt2b^Gena263 Genetic Background: involves: BALB/c * C3H/HeH
MP:0000432	abnormal head morphology	"anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0000914	exencephaly	"neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Kmt2b^Gena263/Kmt2b^Gena263 Genetic Background: involves: BALB/c * C3H/HeH
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Meg3^{Gt(pGTi)216Gos}/Meg3⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Kmt2b^tm1.2Afst/Kmt2b^tm1.2Afst Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gjb2^tm2.2Kwi/Gjb2⁺,Tg(Pgk1-cre)1Lni/0 Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Meg3^{Gt(pGTi)216Gos}/Meg3⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Kmt2b^tm1.2Afst/Kmt2b^tm1.2Afst Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0001700	abnormal embryo turning	"atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Gjb2^tm2.2Kwi/Gjb2⁺,Tg(Pgk1-cre)1Lni/0 Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Kmt2b^tm2.1Afst/Kmt2b⁺ Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Zp3-cre)3Mrt/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0001750	increased circulating follicle stimulating hormone level	"higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Amhr2^tm3(cre)Bhr/Amhr2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Gdf9-icre)5092Coo/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Zp3-cre)3Mrt/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0001751	increased circulating luteinizing hormone level	"higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Gdf9-icre)5092Coo/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Gjb2^tm2.2Kwi/Gjb2⁺,Tg(Pgk1-cre)1Lni/0 Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Kmt2b^tm2.1Afst/Kmt2b⁺ Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Amhr2^tm3(cre)Bhr/Amhr2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Amhr2^tm3(cre)Bhr/Amhr2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Zp3-cre)3Mrt/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Kmt2b^m1H/Kmt2b⁺ Genetic Background: involves: BALB/c * C3H/HeH Allelic Composition: Kmt2b^tm1Afst/Kmt2b⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kmt2b^tm1.2Afst/Kmt2b^tm1.2Afst Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0002678	increased follicle recruitment		Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Gdf9-icre)5092Coo/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Kmt2b^m1H/Kmt2b⁺ Genetic Background: involves: BALB/c * C3H/HeH
MP:0003059	decreased insulin secretion	"less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Kmt2b^m1H/Kmt2b⁺ Genetic Background: involves: BALB/c * C3H/HeH Allelic Composition: Kmt2b^tm1Afst/Kmt2b⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0003400	kinked neural tube	"twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Meg3^{Gt(pGTi)216Gos}/Meg3⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Kmt2b^tm1.2Afst/Kmt2b^tm1.2Afst Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0003787	abnormal imprinting	"defect in the normal inactivation of specific loci during gametogenesis" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Gdf9-icre)5092Coo/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Meg3^{Gt(pGTi)216Gos}/Meg3⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Kmt2b^tm1.2Afst/Kmt2b^tm1.2Afst Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL Allelic Composition: Kmt2b^Gena263/Kmt2b^Gena263 Genetic Background: involves: BALB/c * C3H/HeH
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0005181	decreased circulating estradiol level	"less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Gdf9-icre)5092Coo/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Kmt2b^m1H/Kmt2b⁺ Genetic Background: involves: BALB/c * C3H/HeH Allelic Composition: Kmt2b^tm1Afst/Kmt2b⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0005312	pericardial effusion	"escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Kmt2b^Gena263/Kmt2b^Gena263 Genetic Background: involves: BALB/c * C3H/HeH
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Kmt2b^m1H/Kmt2b⁺ Genetic Background: involves: BALB/c * C3H/HeH Allelic Composition: Kmt2b^tm1Afst/Kmt2b⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Kmt2b^m1H/Kmt2b⁺ Genetic Background: involves: BALB/c * C3H/HeH Allelic Composition: Kmt2b^tm1Afst/Kmt2b⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Gdf9-icre)5092Coo/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Meg3^{Gt(pGTi)216Gos}/Meg3⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Kmt2b^tm1.2Afst/Kmt2b^tm1.2Afst Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0008869	anovulation	"complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Gdf9-icre)5092Coo/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
MP:0008871	abnormal ovarian follicle number	"abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Amhr2^tm3(cre)Bhr/Amhr2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Gdf9-icre)5092Coo/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Zp3-cre)3Mrt/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0008877	abnormal DNA methylation	"any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]	Show Allelic Composition: Gjb2^tm2.2Kwi/Gjb2⁺,Tg(Pgk1-cre)1Lni/0 Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Amhr2^tm3(cre)Bhr/Amhr2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Gdf9-icre)5092Coo/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Zp3-cre)3Mrt/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0009171	enlarged pancreatic islets	"increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0009288	increased epididymal fat pad weight		Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0009289	decreased epididymal fat pad weight		Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Kmt2b^m1H/Kmt2b⁺ Genetic Background: involves: BALB/c * C3H/HeH
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0009648	abnormal superovulation	"impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Gdf9-icre)5092Coo/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Zp3-cre)3Mrt/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0010359	increased liver free fatty acids level	"elevated liver concentrations of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Gtf2i^tm1Vcam/Gtf2i^tm1Vcam Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0010767	abnormal female meiosis I arrest	"any anomaly in the process in which oocytes stop at the diplotene stage of meiosis I and lie dormant, often for long periods of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst,Tg(Gdf9-icre)5092Coo/0 Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Kmt2b^Gena263/Kmt2b^Gena263 Genetic Background: involves: BALB/c * C3H/HeH
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Meg3^{Gt(pGTi)216Gos}/Meg3⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Kmt2b^tm1.2Afst/Kmt2b^tm1.2Afst Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0011102	partial embryonic lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Kmt2b^Gena263/Kmt2b^Gena263 Genetic Background: involves: BALB/c * C3H/HeH
MP:0011107	partial embryonic lethality before turning of embryo	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]	Show Allelic Composition: Kmt2b^tm1Afst/Kmt2b⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0011112	partial lethality during fetal growth through weaning	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Kmt2b^Gena263/Kmt2b^Gena263 Genetic Background: involves: BALB/c * C3H/HeH
MP:0011704	decreased fibroblast proliferation	"reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]	Show Allelic Composition: Btk^m2Anu/Btk^m2Anu Genetic Background: C57BL/6NCrlAnu-Btk^m2Anu
MP:0012157	rostral body truncation	"rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]	Show Allelic Composition: Kmt2b^Gena263/Kmt2b^Gena263 Genetic Background: involves: BALB/c * C3H/HeH

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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