ENSMUSG00000038056


Mus musculus

Features
Gene ID: ENSMUSG00000038056
  
Biological name :Kmt2c
  
Synonyms : Kmt2c / lysine methyltransferase 2C
  
Possible biological names infered from orthology : Q8NEZ4
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B1
Gene start: 25271798
Gene end: 25498783
  
Corresponding Affymetrix probe sets: 10528723 (MoGene1.0st)   1427150_at (Mouse Genome 430 2.0 Array)   1434178_at (Mouse Genome 430 2.0 Array)   1434179_at (Mouse Genome 430 2.0 Array)   1457193_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133482
Ensembl peptide - ENSMUSP00000043874
Ensembl peptide - ENSMUSP00000133304
Ensembl peptide - ENSMUSP00000133941
Ensembl peptide - ENSMUSP00000134442
NCBI entrez gene - 231051     See in Manteia.
MGI - MGI:2444959
RefSeq - XM_017320827
RefSeq - XM_017320821
RefSeq - XM_017320822
RefSeq - XM_017320823
RefSeq - XM_017320824
RefSeq - XM_017320825
RefSeq - XM_017320826
RefSeq - NM_001081383
RefSeq - XM_006535682
RefSeq - XM_006535683
RefSeq - XM_006535685
RefSeq - XM_006535686
RefSeq - XM_006535688
RefSeq - XM_006535689
RefSeq - XM_006535690
RefSeq - XM_006535692
RefSeq - XM_006535693
RefSeq - XM_006535694
RefSeq - XM_006535696
RefSeq - XM_006535697
RefSeq - XM_006535698
RefSeq - XM_006535699
RefSeq - XM_006535700
RefSeq - XM_006535701
RefSeq - XM_006535703
RefSeq - XM_011249766
RefSeq - XM_017320819
RefSeq - XM_017320820
RefSeq Peptide - NP_001074852
swissprot - G3UWZ3
swissprot - G3UY45
swissprot - G3UZC8
swissprot - G3UWI5
swissprot - F8WI37
Ensembl - ENSMUSG00000038056
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kmt2caENSDARG00000079312Danio rerio
 kmt2cbENSDARG00000075560Danio rerio
 ENSGALG00000043738Gallus gallus
 ENSGALG00000032600Gallus gallus
 KMT2CENSG00000055609Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kmt2d / Q6PDK2 / Histone-lysine N-methyltransferase 2D / O14686* / lysine methyltransferase 2D*ENSMUSG0000004815435
Kmt2a / P55200 / Mus musculus lysine (K)-specific methyltransferase 2A (Kmt2a), transcript variant 1, mRNA. / Q03164* / lysine methyltransferase 2A*ENSMUSG0000000202812
Kmt2b / O08550 / Histone-lysine N-methyltransferase 2B / Q9UMN6* / lysine methyltransferase 2B*ENSMUSG0000000630710
Q8CFT2 / Setd1b / Histone-lysine N-methyltransferase SETD1B / Q9UPS6* / SET domain containing 1B*ENSMUSG000000383848
Setd1a / SET domain containing 1A / O15047*ENSMUSG000000423086
AC149222.1 / O15047* / SETD1A* / SET domain containing 1A*ENSMUSG000001088155


Protein motifs (from Interpro)
Interpro ID Name
 IPR000637  HMG-I/HMG-Y, DNA-binding, conserved site
 IPR001214  SET domain
 IPR001841  Zinc finger, RING-type
 IPR001965  Zinc finger, PHD-type
 IPR003616  Post-SET domain
 IPR003888  FY-rich, N-terminal
 IPR003889  FY-rich, C-terminal
 IPR009071  High mobility group box domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR019787  Zinc finger, PHD-finger
 IPR034732  Extended PHD (ePHD) domain
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0051568 histone H3-K4 methylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0035097 histone methyltransferase complex IEA
 cellular_componentGO:0044666 MLL3/4 complex IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Foxg1tm1(tTA)Lai/Foxg1+,Tg(tetO-Gsx2,-EGFP)1Kcam/0
Genetic Background: involves: 129S1/Sv

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Pdgfrbtm1Sor/Pdgfrbtm5Sor
Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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