ENSMUSG00000018547


Mus musculus

Features
Gene ID: ENSMUSG00000018547
  
Biological name :Pip4k2b
  
Synonyms : Phosphatidylinositol 5-phosphate 4-kinase type-2 beta / Pip4k2b / Q80XI4
  
Possible biological names infered from orthology : P78356
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 97715157
Gene end: 97744704
  
Corresponding Affymetrix probe sets: 10390473 (MoGene1.0st)   1427438_at (Mouse Genome 430 2.0 Array)   1435068_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018691
NCBI entrez gene - 108083     See in Manteia.
MGI - MGI:1934234
RefSeq - NM_054051
RefSeq Peptide - NP_473392
swissprot - Q3UJ95
swissprot - Q80XI4
Ensembl - ENSMUSG00000018547
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PIP4K2BENSGALG00000001610Gallus gallus
 P78356ENSG00000276293Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O70172 / Pip4k2a / Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha / P48426*ENSMUSG0000002673776
Q91XU3 / Pip4k2c / Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma / Q8TBX8*ENSMUSG0000002541764
O70161 / Pip5k1c / Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma / O60331*ENSMUSG0000003490232
P70182 / Pip5k1a / Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha / Q99755*ENSMUSG0000002812631
P70181 / Pip5k1b / Phosphatidylinositol 4-phosphate 5-kinase type-1 beta / O14986*ENSMUSG0000002486731
Q6U7H8 / Pip5kl1 / Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 / Q5T9C9* / phosphatidylinositol-4-phosphate 5-kinase like 1*ENSMUSG0000004685419


Protein motifs (from Interpro)
Interpro ID Name
 IPR002498  Phosphatidylinositol-4-phosphate 5-kinase, core
 IPR023610  Phosphatidylinositol-4-phosphate 5-kinase
 IPR027483  Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
 IPR027484  Phosphatidylinositol-4-phosphate 5-kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:2000786 positive regulation of autophagosome assembly IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016307 phosphatidylinositol phosphate kinase activity IEA
 molecular_functionGO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity IEA
 molecular_functionGO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
PI5P Regulates TP53 Acetylation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Synthesis of PIPs in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Pip4k2bGt(Betageo)1Lca/Pip4k2bGt(Betageo)1Lca,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Pip4k2bGt(Betageo)1Lca/Pip4k2bGt(Betageo)1Lca,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

Allelic Composition: Pip4k2atm1.2Lca/Pip4k2a+,Pip4k2bGt(Betageo)1Lca/Pip4k2bGt(Betageo)1Lca
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pip4k2atm1.2Lca/Pip4k2a+,Pip4k2bGt(Betageo)1Lca/Pip4k2bGt(Betageo)1Lca
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pip4k2atm1.2Lca/Pip4k2a+,Pip4k2bGt(Betageo)1Lca/Pip4k2bGt(Betageo)1Lca
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0004601 abnormal vertebral spinous process "any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn1Gt(OST378842)Lex/Ptpn1Gt(OST378842)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Pip4k2bGt(Betageo)1Lca/Pip4k2bGt(Betageo)1Lca,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Pip4k2atm1.2Lca/Pip4k2a+,Pip4k2bGt(Betageo)1Lca/Pip4k2bGt(Betageo)1Lca
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pip4k2bGt(Betageo)1Lca/Pip4k2bGt(Betageo)1Lca,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026737 O70172 / Pip4k2a / Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha / P48426*  / complex
 ENSMUSG00000074997 Pin1rt1 / PIN1* / Q13526* / peptidylprolyl cis/trans isomerase, NIMA-interacting 1*  / complex / reaction
 ENSMUSG00000018547 Q80XI4 / Pip4k2b / Phosphatidylinositol 5-phosphate 4-kinase type-2 beta / P78356*  / complex
 ENSMUSG00000032171 Pin1 / Q9QUR7 / Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 / Q13526* / peptidylprolyl cis/trans isomerase, NIMA-interacting 1*  / complex / reaction
 ENSMUSG00000020623 Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*  / reaction
 ENSMUSG00000025417 Q91XU3 / Pip4k2c / Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma / Q8TBX8*  / complex






 

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