ENSMUSG00000034902


Mus musculus

Features
Gene ID: ENSMUSG00000034902
  
Biological name :Pip5k1c
  
Synonyms : O70161 / Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma / Pip5k1c
  
Possible biological names infered from orthology : O60331
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 81292963
Gene end: 81319973
  
Corresponding Affymetrix probe sets: 10365069 (MoGene1.0st)   1424954_a_at (Mouse Genome 430 2.0 Array)   1450228_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125461
Ensembl peptide - ENSMUSP00000038225
Ensembl peptide - ENSMUSP00000124612
Ensembl peptide - ENSMUSP00000125645
Ensembl peptide - ENSMUSP00000124155
Ensembl peptide - ENSMUSP00000124004
Ensembl peptide - ENSMUSP00000100964
Ensembl peptide - ENSMUSP00000124235
NCBI entrez gene - 18717     See in Manteia.
MGI - MGI:1298224
RefSeq - NM_001293646
RefSeq - NM_008844
RefSeq - NM_001146687
RefSeq - NM_001293647
RefSeq Peptide - NP_001280575
RefSeq Peptide - NP_001140159
RefSeq Peptide - NP_032870
RefSeq Peptide - NP_001280576
swissprot - O70161
swissprot - E0CYP4
swissprot - E0CZ71
swissprot - F6SMP3
swissprot - F6TL71
swissprot - F7C0X9
swissprot - F8WHW6
Ensembl - ENSMUSG00000034902
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pip5k1caENSDARG00000076001Danio rerio
 pip5k1cbENSDARG00000100313Danio rerio
 PIP5K1CENSGALG00000000784Gallus gallus
 O60331ENSG00000186111Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70182 / Pip5k1a / Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha / Q99755*ENSMUSG0000002812652
P70181 / Pip5k1b / Phosphatidylinositol 4-phosphate 5-kinase type-1 beta / O14986*ENSMUSG0000002486749
Q80XI4 / Pip4k2b / Phosphatidylinositol 5-phosphate 4-kinase type-2 beta / P78356*ENSMUSG0000001854719
Q91XU3 / Pip4k2c / Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma / Q8TBX8*ENSMUSG0000002541718
O70172 / Pip4k2a / Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha / P48426*ENSMUSG0000002673718
Q6U7H8 / Pip5kl1 / Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 / Q5T9C9* / phosphatidylinositol-4-phosphate 5-kinase like 1*ENSMUSG0000004685413


Protein motifs (from Interpro)
Interpro ID Name
 IPR002498  Phosphatidylinositol-4-phosphate 5-kinase, core
 IPR023610  Phosphatidylinositol-4-phosphate 5-kinase
 IPR027483  Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
 IPR027484  Phosphatidylinositol-4-phosphate 5-kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process IMP
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007016 cytoskeletal anchoring at plasma membrane IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007409 axonogenesis IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0070527 platelet aggregation IMP
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0001931 uropod IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016307 phosphatidylinositol phosphate kinase activity IEA
 molecular_functionGO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity IMP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:1990147 talin binding IDA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Pip5k1ctm2.1Ref/Pip5k1ctm2.1Ref
Genetic Background: B6.129-Pip5k1ctm2.1Ref

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pip5k1ctm1.2Ref/Pip5k1ctm1.2Ref
Genetic Background: involves: 129

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0002916 increased synaptic depression "increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0004770 abnormal synaptic vesicle recycling "any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Engc/Pten+
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129 * A/J * C57BL/6J) or (involves: 129 * C57BL/6J * CD-1)

Allelic Composition: Pip5k1ctm1.2Ref/Pip5k1ctm1.2Ref
Genetic Background: involves: 129

 MP:0004783 abnormal cardinal vein morphology "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Pip5k1ctm2Csab/Pip5k1ctm2Csab
Genetic Background: Not Specified

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Engc/Pten+
Genetic Background: either: (involves: 129 * CD-1) or (involves: 129 * A/J * C57BL/6J) or (involves: 129 * C57BL/6J * CD-1)

Allelic Composition: Pip5k1ctm1.2Ref/Pip5k1ctm1.2Ref
Genetic Background: involves: 129

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Cacna1btm2.1Dili/Cacna1btm2.1Dili
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Pip5k1ctm2.1Ref/Pip5k1ctm2.1Ref
Genetic Background: B6.129-Pip5k1ctm2.1Ref

 MP:0009548 abnormal platelet aggregation "any functional anomaly in the adhesion of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Pip5k1ctm2Csab/Pip5k1ctm2Csab
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Pip5k1ctm2.1Ref/Pip5k1ctm2.1Ref
Genetic Background: B6.129-Pip5k1ctm2.1Ref

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Opn4tm1Yau/Opn4tm2(DTA)Yau
Genetic Background: involves: 129 * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nphp1tm1.1(KOMP)Vlcg/Nphp1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nphp1tm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Pip5k1ctm1a(KOMP)Wtsi/Pip5k1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Pip5k1ctm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / complex
 ENSMUSG00000034066 Farp2 / Q91VS8 / FERM, ARHGEF and pleckstrin domain-containing protein 2 / O94887* / FERM, ARH/RhoGEF and pleckstrin domain protein 2*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr