ENSMUSG00000020623


Mus musculus

Features
Gene ID: ENSMUSG00000020623
  
Biological name :Map2k6
  
Synonyms : Map2k6 / mitogen-activated protein kinase kinase 6 / P70236
  
Possible biological names infered from orthology : P52564
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 110399122
Gene end: 110525522
  
Corresponding Affymetrix probe sets: 10382300 (MoGene1.0st)   1426850_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020949
Ensembl peptide - ENSMUSP00000097831
NCBI entrez gene - 26399     See in Manteia.
MGI - MGI:1346870
RefSeq - XM_011249035
RefSeq - NM_001356345
RefSeq - NM_001356352
RefSeq - NM_011943
RefSeq - XM_006533377
RefSeq - XM_006533378
RefSeq - XM_011249034
RefSeq Peptide - NP_001343274
RefSeq Peptide - NP_001343281
RefSeq Peptide - NP_036073
swissprot - P70236
swissprot - Q543Z5
swissprot - A2AGS2
Ensembl - ENSMUSG00000020623
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k6ENSDARG00000099184Danio rerio
 MAP2K6ENSGALG00000004370Gallus gallus
 MAP2K6ENSG00000108984Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map2k3 / O09110 / mitogen-activated protein kinase kinase 3 / P46734*ENSMUSG0000001893277
Map2k4 / P47809 / Dual specificity mitogen-activated protein kinase kinase 4 / P45985* / mitogen-activated protein kinase kinase 4*ENSMUSG0000003335255
Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*ENSMUSG0000010906146
Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*ENSMUSG0000000294846
Map2k5 / Q9WVS7 / Dual specificity mitogen-activated protein kinase kinase 5 / Q13163* / mitogen-activated protein kinase kinase 5*ENSMUSG0000005844440
Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*ENSMUSG0000003502739
Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*ENSMUSG0000000493637


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IPI
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0022602 ovulation cycle process IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032308 positive regulation of prostaglandin secretion IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IEA
 biological_processGO:0060048 cardiac muscle contraction IMP
 biological_processGO:0072709 cellular response to sorbitol IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004708 MAP kinase kinase activity TAS
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
Oxidative Stress Induced Senescence
activated TAK1 mediates p38 MAPK activation
PI5P Regulates TP53 Acetylation
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmtf1tm1Cjs/Dmtf1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Map2k6tm1Ina/Map2k6tm1Ina,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Allelic Composition: Map2k6tm1Ina/Map2k6tm1Ina,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Map2k6tm1Ina/Map2k6tm1Ina,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

 MP:0009258 abnormal thymocyte apoptosis "change in the timing or the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893]
Show

Allelic Composition: Emx2tm1Pgr/Emx2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029454 O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*  / reaction
 ENSMUSG00000053436 Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*  / reaction
 ENSMUSG00000018547 Q80XI4 / Pip4k2b / Phosphatidylinositol 5-phosphate 4-kinase type-2 beta / P78356*  / reaction
 ENSMUSG00000032577 Q3UMW7 / Mapkapk3 / MAP kinase-activated protein kinase 3 / Q16644* / mitogen-activated protein kinase-activated protein kinase 3*  / reaction
 ENSMUSG00000053137 Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*  / reaction
 ENSMUSG00000026737 O70172 / Pip4k2a / Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha / P48426*  / reaction
 ENSMUSG00000016528 P49138 / Mapkapk2 / MAP kinase-activated protein kinase 2 / P49137* / mitogen-activated protein kinase-activated protein kinase 2*  / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / reaction
 ENSMUSG00000071369 Map3k5 / O35099 / Mitogen-activated protein kinase kinase kinase 5 / Q99683*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr