ENSMUSG00000109061


Mus musculus

Features
Gene ID: ENSMUSG00000109061
  
Biological name :Map2k7
  
Synonyms : Dual specificity mitogen-activated protein kinase kinase 7 / Map2k7 / Q8CE90
  
Possible biological names infered from orthology : mitogen-activated protein kinase kinase 7 / O14733
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 4238865
Gene end: 4251423
  
Corresponding Affymetrix probe sets: 10569927 (MoGene1.0st)   1425393_a_at (Mouse Genome 430 2.0 Array)   1440442_at (Mouse Genome 430 2.0 Array)   1457182_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117418
MGI - MGI:1346871
MGI - MGI:6121499
swissprot - Q8CE90
Ensembl - ENSMUSG00000109061
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k7ENSDARG00000008279Danio rerio
 MAP2K7ENSG00000076984Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map2k7 / Q8CE90 / Dual specificity mitogen-activated protein kinase kinase 7 / O14733* / mitogen-activated protein kinase kinase 7*ENSMUSG0000000294882
Map2k4 / P47809 / Dual specificity mitogen-activated protein kinase kinase 4 / P45985* / mitogen-activated protein kinase kinase 4*ENSMUSG0000003335233
Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*ENSMUSG0000002062329
Map2k3 / O09110 / mitogen-activated protein kinase kinase 3 / P46734*ENSMUSG0000001893227
Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*ENSMUSG0000003502725
Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*ENSMUSG0000000493624
Map2k5 / Q9WVS7 / Dual specificity mitogen-activated protein kinase kinase 5 / Q13163* / mitogen-activated protein kinase kinase 5*ENSMUSG0000005844422


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006970 response to osmotic stress ISO
 biological_processGO:0007257 activation of JUN kinase activity IDA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0009408 response to heat ISO
 biological_processGO:0009411 response to UV ISO
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase ISO
 biological_processGO:0034612 response to tumor necrosis factor ISO
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0051403 stress-activated MAPK cascade ISO
 biological_processGO:0051973 positive regulation of telomerase activity ISO
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0071347 cellular response to interleukin-1 IMP
 biological_processGO:1904355 positive regulation of telomere capping ISO
 biological_processGO:2000671 regulation of motor neuron apoptotic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity ISO
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008545 JUN kinase kinase activity IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016909 SAP kinase activity IDA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000630 mammary gland hyperplasia "increased size of mammary gland due to increased cell number" [J:63229]
Show

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
Show

Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp3tm1.2Ics/Parp3tm1.2Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Krastm4Tyj/Kras+,Map2k7tm1.1Twad/Map2k7tm1.2Twad
Genetic Background: B6.Cg-Krastm4Tyj Map2k7tm1.1Twad/Map2k7tm1.2Twad

Allelic Composition: Krastm4Tyj/Kras+,Map2k7tm1.1Twad/Map2k7tm1.2Twad,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Map2k7tm1.1Twad/Map2k7tm1.2Twad
Genetic Background: B6.Cg-Krastm4Tyj Map2k7tm1.1Twad/Map2k7tm1.2Twad

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp3tm1.2Ics/Parp3tm1.2Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Map2k7tm1.1Twad/Map2k7tm1.2Twad
Genetic Background: B6.Cg-Krastm4Tyj Map2k7tm1.1Twad/Map2k7tm1.2Twad

Allelic Composition: Krastm4Tyj/Kras+,Map2k7tm1.1Twad/Map2k7tm1.2Twad,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Krastm4Tyj/Kras+,Map2k7tm1.1Twad/Map2k7tm1.2Twad
Genetic Background: B6.Cg-Krastm4Tyj Map2k7tm1.1Twad/Map2k7tm1.2Twad

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsd11b1tm1Ggla/Hsd11b1tm1Ggla,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map2k7tm1.1Twad/Map2k7tm1.2Twad,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Id4tm1Fsky/Id4tm1Fsky
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Map2k7tm2.1Rjd/Map2k7tm2.1Rjd
Genetic Background: B6.129S6-Map2k7tm2.1Rjd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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